DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kermit and gipc3

DIOPT Version :9

Sequence 1:	NP_001286187.1	Gene:	kermit / 46027	FlyBaseID:	FBgn0010504	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001038783.1	Gene:	gipc3 / 724013	ZFINID:	ZDB-GENE-060616-326	Length:	333	Species:	Danio rerio

Alignment Length:	319	Identity:	176/319 - (55%)
Similarity:	218/319 - (68%)	Gaps:	15/319 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QFGSRSSMNSGSSQGSHISNNNNNSIPEK----------TKPPLVFHCQLAHGSPTGLIHDFSSV 74
            |.|...|.....|.|......:.:::|..          .:|.||||.|||||||||.||.|::|
Zfish    16 QNGEAMSPGPQDSTGPPGDEESQSTVPSAPPLPPDAAPCPRPKLVFHTQLAHGSPTGRIHGFTNV 80

  Fly    75 RELYQKIAECFDISEKDILFCTLNSHKVDMTRLLGGQIGLDDFIFAHRKGRPKEIEIVKSQDALG 139
            ||||.||||.|:||..:|||||||||||||.:||||||||:||||||.:|..||:|::|::||||
Zfish    81 RELYAKIAEVFNISPSEILFCTLNSHKVDMQKLLGGQIGLEDFIFAHVRGETKEVEVIKTEDALG 145

  Fly   140 LTITDNGAGYAFIKRIKEDSIIDRIEHISVGDHIEKLNGQNMVGKRHYEVARMLKDIATGETFTL 204
            ||||||||||||||||||.|.||||:.:.||||||.:|.|::||.||||||:|||:...|..|||
Zfish   146 LTITDNGAGYAFIKRIKEGSTIDRIKSVCVGDHIEAINDQSIVGCRHYEVAKMLKEQPRGTPFTL 210

  Fly   205 RLVEPVRSGFQGIGPRSQSRASGSAGGKNYGSGKETLRFKANGNAQIEPQFDEATVAGIEAINNL 269
            ||||| :..|..||.|  :||..|:.|| ..|||||||.:..|:|.:|....|...|.|..:::|
Zfish   211 RLVEP-KKAFDMIGQR--TRAPKSSEGK-LSSGKETLRLRTRGSASLEEIPSELEDAAIRKVDDL 271

  Fly   270 LESFMGINDTELASQIWDLGDQKSNSMDFAEAIDNSDLESFGFTDDFIIELWGAITDAR 328
            |||:|||.|.|||:.|.:.|..|.|..|||||:| |.|..|||.|.|:.::|||:.|.:
Zfish   272 LESYMGIRDLELATTIVEAGKNKKNPDDFAEALD-SVLGDFGFPDVFLFDVWGALGDVK 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kermit	NP_001286187.1	PDZ_signaling	126..207	CDD:238492	55/80 (69%)
gipc3	NP_001038783.1	PDZ_signaling	132..204	CDD:238492	50/71 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595249
Domainoid	1	1.000	125	1.000	Domainoid score	I5407
eggNOG	1	0.900	-	-		E1_KOG3938
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H77068
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2496
OMA	1	1.010	-	-		QHG52512
OrthoDB	1	1.010	-	-		D1442796at2759
OrthoFinder	1	1.000	-	-		FOG0001655
OrthoInspector	1	1.000	-	-		otm25159
orthoMCL	1	0.900	-	-		OOG6_105547
Panther	1	1.100	-	-	O	PTHR12259
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5104
SonicParanoid	1	1.000	-	-		X1053
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800