DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kermit and Gipc1

DIOPT Version :9

Sequence 1:	NP_001286187.1	Gene:	kermit / 46027	FlyBaseID:	FBgn0010504	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_061241.1	Gene:	Gipc1 / 67903	MGIID:	1926252	Length:	333	Species:	Mus musculus

Alignment Length:	338	Identity:	173/338 - (51%)
Similarity:	223/338 - (65%)	Gaps:	19/338 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLFTRKSPKQGPTSDGGSQFGSRSSMN-------SGSSQGSHISNNNNNSIPEKTKPPLVFHCQ 58
            |||...:..|..|..:......|||.:.       .||:.|.  |.......|...:|.||||.|
Mouse     1 MPLGLGRRKKAPPLVENEEAEPSRSGLGVGEPGPLGGSAAGE--SQMGLPPPPAALRPRLVFHTQ 63

  Fly    59 LAHGSPTGLIHDFSSVRELYQKIAECFDISEKDILFCTLNSHKVDMTRLLGGQIGLDDFIFAHRK 123
            ||||||||.|..|::|:|||.||||.|.:...:::|||||:|||||.:||||||||:||||||.|
Mouse    64 LAHGSPTGRIEGFTNVKELYGKIAEAFRLPAAEVMFCTLNTHKVDMDKLLGGQIGLEDFIFAHVK 128

  Fly   124 GRPKEIEIVKSQDALGLTITDNGAGYAFIKRIKEDSIIDRIEHISVGDHIEKLNGQNMVGKRHYE 188
            |:.||:|:.||::|||||||||||||||||||||.|:||.|:.|||||.||.:|||:::|.||||
Mouse   129 GQRKEVEVFKSEEALGLTITDNGAGYAFIKRIKEGSVIDHIQLISVGDMIEAINGQSLLGCRHYE 193

  Fly   189 VARMLKDIATGETFTLRLVEPVRSGFQGIGPRSQSRASGSAGGKNYGSGKETLRFKANGNAQIE- 252
            |||:||::..|.||||:|.|| |..|..|..||.....||  |...|:|:.|||.::.|.|.:|
Mouse   194 VARLLKELPRGRTFTLKLTEP-RKAFDMISQRSAGGHPGS--GPQLGTGRGTLRLRSRGPATVED 255

  Fly   253 --PQFDEATVAGIEAINNLLESFMGINDTELASQIWDLGDQKSNSMDFAEAIDNSDLESFGFTDD 315
              ..|:|   ..||.:::||||:|||.|||||:.:.:||..|.|..:.|||:|.. |..|.|.|:
Mouse   256 LPSAFEE---KAIEKVDDLLESYMGIRDTELAATMVELGKDKRNPDELAEALDER-LGDFAFPDE 316

  Fly   316 FIIELWGAITDAR 328
            |:.::||||.||:
Mouse   317 FVFDVWGAIGDAK 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kermit	NP_001286187.1	PDZ_signaling	126..207	CDD:238492	55/80 (69%)
Gipc1	NP_061241.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		13/53 (25%)
		PDZ_signaling	132..210	CDD:238492	54/77 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..244		8/22 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849523
Domainoid	1	1.000	119	1.000	Domainoid score	I5784
eggNOG	1	0.900	-	-		E1_KOG3938
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	310	1.000	Inparanoid score	I2577
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52512
OrthoDB	1	1.010	-	-		D1442796at2759
OrthoFinder	1	1.000	-	-		FOG0001655
OrthoInspector	1	1.000	-	-		otm44290
orthoMCL	1	0.900	-	-		OOG6_105547
Panther	1	1.100	-	-	O	PTHR12259
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5104
SonicParanoid	1	1.000	-	-		X1053
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800