Protein Alignment kermit and GIPC2

DIOPT Version :10

• Sequence 1: NP_652028.1
• Gene: kermit / 46027
• FlyBaseID: FBgn0010504
• Length: 336
• Species: Drosophila melanogaster
• Sequence 2: XP_047279186.1
• Gene: GIPC2 / 54810
• HGNCID: 18177
• Length: 365
• Species: Homo sapiens
• Alignment Length: 380
• Identity: 153/380 - (40%)
• Similarity: 212/380 - (55%)
• Gaps: 67/380 - (17%)

  Fly     1 MPLFTRKSPKQGPTSDGGSQFGSRSSMNSGSSQGSHISNNNNNSIPEKTKPPLVFHCQLAHGSPT 65
            |||..|...|.......|...|..:....||...|.        .|.:.   ||||.||||||.|
Human     1 MPLKLRGKKKAKSKETAGLVEGEPTGAGGGSLSASR--------APARR---LVFHAQLAHGSAT 54

  Fly    66 GLIHDFSSVRELYQKIAECFDISEKD--------------------------------------- 91
            |.:..|||::|||.:||..|:||..:
Human    55 GRVEGFSSIQELYAQIAGAFEISPSEVRRQVLRLSRLSAAPRRAARISVGPGGLSGVSRSAKSDA 119

  Fly    92 -----------ILFCTLNSHKVDMTRLLGGQIGLDDFIFAHRKGRPKEIEIVKSQDALGLTITDN 145
                       ||:||||:.|:||.||||||:||:||||||.||..||:.:.||:|:||||||||
Human   120 VLSPPGASRGKILYCTLNTPKIDMERLLGGQLGLEDFIFAHVKGIEKEVNVYKSEDSLGLTITDN 184

  Fly   146 GAGYAFIKRIKEDSIIDRIEHISVGDHIEKLNGQNMVGKRHYEVARMLKDIATGETFTLRLVEPV 210
            |.|||||||||:..:||.::.|.||||||.:||:|:||.|||:||:.||::...|.||::|:||
Human   185 GVGYAFIKRIKDGGVIDSVKTICVGDHIESINGENIVGWRHYDVAKKLKELKKEELFTMKLIEP- 248

  Fly   211 RSGFQGIGPRSQSRASGSAGGKNYGSGKETLRFKANGNAQIEPQFDEATVAGIEAINNLLESFMG 275
            :..|: |..||:   :|.:.|:..|.|:.|||.::.|.|.:|....|.....||.|:::||.:||
Human   249 KKAFE-IELRSK---AGKSSGEKIGCGRATLRLRSKGPATVEEMPSETKAKAIEKIDDVLELYMG 309

  Fly   276 INDTELASQIWDLGDQKSNSMDFAEAIDNSDLESFGFTDDFIIELWGAITDARRK 330
            |.|.:||:.:::.|..|.|..:||.|:|.: |..|.|.|:|:.::||.|.||:|:
Human   310 IRDIDLATTMFEAGKDKVNPDEFAVALDET-LGDFAFPDEFVFDVWGVIGDAKRR 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kermit	NP_652028.1	PDZ_GIPC	123..211	CDD:467191	52/87 (60%)
		GH2_GIPC	263..324	CDD:409666	25/60 (42%)
GIPC2	XP_047279186.1	PDZ_GIPC2	160..252	CDD:467291	53/92 (58%)
		GH2_GIPC	293..357	CDD:409666	25/64 (39%)