DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kermit and Gipc2

DIOPT Version :9

Sequence 1:	NP_001286187.1	Gene:	kermit / 46027	FlyBaseID:	FBgn0010504	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001032287.1	Gene:	Gipc2 / 365960	RGDID:	1560751	Length:	314	Species:	Rattus norvegicus

Alignment Length:	332	Identity:	160/332 - (48%)
Similarity:	218/332 - (65%)	Gaps:	23/332 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLFTRKSPKQGPTSDGGSQF-GSRSSMNSGSSQGSHISNNNNNSIPEKTKPP--LVFHCQLAHG 62
            |||..|...|...:.:..... |.|    ||.|||          :|....|.  ||||.|||||
  Rat     1 MPLGLRGKKKAAKSKETARLVEGER----SGGSQG----------VPGPPAPARRLVFHAQLAHG 51

  Fly    63 SPTGLIHDFSSVRELYQKIAECFDISEKDILFCTLNSHKVDMTRLLGGQIGLDDFIFAHRKGRPK 127
            |.||.:.||||:.|||.|||..|:|:..:|||||||:.|:||.:|||||:||:||||||.||..|
  Rat    52 SATGRVEDFSSISELYAKIAGVFEIAPSEILFCTLNTPKIDMGKLLGGQLGLEDFIFAHVKGIKK 116

  Fly   128 EIEIVKSQDALGLTITDNGAGYAFIKRIKEDSIIDRIEHISVGDHIEKLNGQNMVGKRHYEVARM 192
            |:.:.||:|:|||||||||.|||||||||:.|.||.::.|.||||||.:||:|:||.||:|||:.
  Rat   117 EVNVYKSEDSLGLTITDNGVGYAFIKRIKDGSTIDSVKTICVGDHIECINGENIVGWRHFEVAKK 181

  Fly   193 LKDIATGETFTLRLVEPVRSGFQGIGPRSQSRASGSAGGKNYGSGKETLRFKANGNAQIEPQFDE 257
            ||::...|.|||:|:|| :..|: |||||:   :|....:..|:.:.|||.::.|.|.:|....|
  Rat   182 LKELKKEELFTLQLIEP-KKAFE-IGPRSK---AGKTSTEKIGTSRGTLRLRSKGPATVEDLPSE 241

  Fly   258 ATVAGIEAINNLLESFMGINDTELASQIWDLGDQKSNSMDFAEAIDNSDLESFGFTDDFIIELWG 322
            |....||.:::|||.:|||.|.:||:.:::.|..|||..:||.|:|.: |..|.|.|:|:.::||
  Rat   242 AKAKAIEKVDDLLELYMGIRDIDLATTMFEAGKDKSNPDEFAVALDET-LGDFAFPDEFMFDVWG 305

  Fly   323 AITDARR 329
            ||:|.::
  Rat   306 AISDVKQ 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kermit	NP_001286187.1	PDZ_signaling	126..207	CDD:238492	49/80 (61%)
Gipc2	NP_001032287.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		13/48 (27%)
		PDZ_signaling	116..179	CDD:238492	41/62 (66%)
		GH2_GIPC	243..307	CDD:409666	26/64 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353168
Domainoid	1	1.000	120	1.000	Domainoid score	I5605
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	313	1.000	Inparanoid score	I2497
OMA	1	1.010	-	-		QHG52512
OrthoDB	1	1.010	-	-		D1442796at2759
OrthoFinder	1	1.000	-	-		FOG0001655
OrthoInspector	1	1.000	-	-		otm46390
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12259
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1053
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.010