Protein Alignment NAT1 and EIF4G3

DIOPT Version :10

• Sequence 1: NP_001033943.2
• Gene: NAT1 / 46020
• FlyBaseID: FBgn0010488
• Length: 1488
• Species: Drosophila melanogaster
• Sequence 2: XP_047289187.1
• Gene: EIF4G3 / 8672
• HGNCID: 3298
• Length: 1822
• Species: Homo sapiens
• Alignment Length: 1112
• Identity: 291/1112 - (26%)
• Similarity: 449/1112 - (40%)
• Gaps: 306/1112 - (27%)

  Fly   460 LNSGSASAAGGGTPHSQQQQERSQAGKASTPPPI--------------TGRWIPPSLR-PQHGLT 509
            ||.||               .|||.|:...|..|              ...|.|...| .|....
Human   934 LNVGS---------------RRSQPGQRREPRKIITVSVKEDVHLKKAENAWKPSQKRDSQADDP 983

  Fly   510 QSEKNDAVFRRVRGILNKLTPEKFQELSDELLKLDLNSIAILKGVILLIFDKALDEPKYSSMYAQ 574
            ::.|...:||:||.|||||||:.|.:|..::..|.:::...|||||.|:|:||:|||.:|..||.
Human   984 ENIKTQELFRKVRSILNKLTPQMFNQLMKQVSGLTVDTEERLKGVIDLVFEKAIDEPSFSVAYAN 1048

  Fly   575 LCKRL-SEEAPSFDKEPSNSSTFLRLLIAVCRDKFNNRLKRDENDNRPPPENEA----------- 627
            :|:.| :.:.|..|| |.|:..|.:||:..|:.:|......|:...:...|.||
Human  1049 MCRCLVTLKVPMADK-PGNTVNFRKLLLNRCQKEFEKDKADDDVFEKKQKELEAASAPEERTRLH 1112

  Fly   628 DE-EERRHLAKQRMLGNVKFIGELNKLDMLSKNVLHQCIMELFDKKKKRTAGTQEMCEDMECLAQ 691
            || ||.:..|::|.:||:||||||.||.||::.::|.|:::|.....:         |.:|||.:
Human  1113 DELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDE---------ESLECLCR 1168

  Fly   692 LLKTCGKNLDSEQGKELMNQYFEKLERRSKSSEYPPRIRFMLKDVIELRQNNWVPRKLGTTEGPV 756
            ||.|.||:||.|:.|..|:|||.::|:..|..:...||||||:|||:||..|||.|:  ..:||.
Human  1169 LLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLCNWVSRR--ADQGPK 1231

  Fly   757 PIKQIRSDDDSIIRTPFPNRNRDMRNNDRDSDSWMNRFH-----LNIQPGGYNDMFSGLSVTGA- 815
            .|:||..:           ...:.:...|.....|.:..     ..:..||:|      :|.||
Human  1232 TIEQIHKE-----------AKIEEQEEQRKVQQLMTKEKRRPGVQRVDEGGWN------TVQGAK 1279

  Fly   816 -SPIVSP--FATSNRDRDRDNRQYNNRGDRNRDRDQGGSGGANYGNRYNKHNQNGGGSGGGSSNN 877
             |.::.|  |....:....:..|...:.       |.||.|.             |.|||..::.
Human  1280 NSRVLDPSKFLKITKPTIDEKIQLVPKA-------QLGSWGK-------------GSSGGAKASE 1324

  Fly   878 RDRDDSRRNNDRDRDRNDGQYGGNQLLGSKELAPRFKRNLITTNQDAVENLQMRPAANSLLFRAA 942
            .|                                                 .:|.:|:||
Human  1325 TD-------------------------------------------------ALRSSASSL----- 1335

  Fly   943 SQNQKFPATLPMSTPPNSSGSNNQGSSQGQLSNSHYPMLGTPTSHLINPTRPSSTPSAEYADNRT 1007
               .:|.|.    .||..|||                   ||           ||| .|:...||
Human  1336 ---NRFSAL----QPPAPSGS-------------------TP-----------STP-VEFDSRRT 1362

  Fly  1008 L-----LGVQQ-ERGLKATSSSPN-FSSGAEKLD-LDGQAGRKGSHDGKDQGK----NGSVERPS 1060
            |     :|.:: ::.|.:.::.|| |..|....| ||.|:..:...:..:..|    ...|||.|
Human  1363 LTSRGSMGREKNDKPLPSATARPNTFMRGGSSKDLLDNQSQEEQRREMLETVKQLTGGVDVERNS 1427

  Fly  1061 TPAGGIGSAKQQKKDKGPNKEELSKKASQYFKDRFYYDEEEDAEVTE------IEIKDIDETK-- 1117
            |.|       ::.|.:...|.|:|..::.   |:....|||....::      :.|.|..|..
Human  1428 TEA-------ERNKTRESAKPEISAMSAH---DKAALSEEELERKSKSIIDEFLHINDFKEAMQC 1482

  Fly  1118 TEEADA-------APVEVSEVKEDAAIPVTTPDRFTKLVDGFLELKLPEKALKDVCINLLMEVLD 1175
            .||.:|       ..|.|....|.:.|   |.|...:|:   .:|...||..|........|.|:
Human  1483 VEELNAQGLLHVFVRVGVESTLERSQI---TRDHMGQLL---YQLVQSEKLSKQDFFKGFSETLE 1541

  Fly  1176 RVNDVFLE------RAVRLLQTLRKQSNIK-PNIVVEIFKQV--VNKMNEREALNPRIVSLVASL 1231
            ..:|:.::      ....|:..:.|:..|. ..:.:|..|.:  |.:...       ::|.:..|
Human  1542 LADDMAIDIPHIWLYLAELVTPMLKEGGISMRELTIEFSKPLLPVGRAGV-------LLSEILHL 1599

  Fly  1232 LAKTICEP---ALLKLSDIA--NFTDNGQHYPLFLLVLQQLVKVIGKDALEEKFRASKVDLMNSL 1291
            |.|.:...   ||.:.:|::  :|...|:....||  |:|.:..|..|:.......||.:|  |.
Human  1600 LCKQMSHKKVGALWREADLSWKDFLPEGEDVHNFL--LEQKLDFIESDSPCSSEALSKKEL--SA 1660

  Fly  1292 PEADRNKERLAGILEDRKLSFLYPLLKVQAEMLKQLQSDPNPNNFYKWIKANVDNKYYKDPGFIQ 1356
            .|..:..|:|  |:||:                      .|....:.|::||:|......|.|::
Human  1661 EELYKRLEKL--IIEDK----------------------ANDEQIFDWVEANLDEIQMSSPTFLR 1701

  Fly  1357 ALMTVVVKYVTKETTLADNLDPKEHPEKSVTQKEQQLLENYSQMLQTFL-GQNELQLMALYALQT 1420
            ||||.    |.|...:||:         |..:.:..:::....:|..:| ...|.:|.||||||.
Human  1702 ALMTA----VCKAAIIADS---------STFRVDTAVIKQRVPILLKYLDSDTEKELQALYALQA 1753

  Fly  1421 FCYNENFPKGMLCRWFKYLYESEIIEEEAFVLWKEEISDKYP----GKGSALFQVNAWLTWLQEA 1481
            .....:.|..:|..:|..||:.|:|.|:||..|:   |.|.|    |||.||..|.|:.|||:||
Human  1754 SIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWE---SSKDPAEQNGKGVALKSVTAFFTWLREA 1815

  Fly  1482 ESEDDED 1488
            |.|.:::
Human  1816 EEESEDN 1822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAT1	NP_001033943.2	MIF4G	518..743	CDD:397130	96/237 (41%)
		RAM	<817..860	CDD:464643	7/44 (16%)
		MA3	1128..1241	CDD:214714	23/124 (19%)
		W2_eIF4G1_like	1314..1460	CDD:211397	38/146 (26%)
EIF4G3	XP_047289187.1	PHA03378	<74..492	CDD:223065
		MIF4G	992..1220	CDD:397130	96/237 (41%)
		MA3	1459..1571	CDD:397128	22/117 (19%)
		W2_eIF4G1_like	1665..1793	CDD:211397	44/167 (26%)
		W2	<1772..1818	CDD:473053	24/48 (50%)