DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAT1 and TIF4632

DIOPT Version :9

Sequence 1:	NP_001033943.2	Gene:	NAT1 / 46020	FlyBaseID:	FBgn0010488	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	NP_011466.1	Gene:	TIF4632 / 852833	SGDID:	S000003017	Length:	914	Species:	Saccharomyces cerevisiae

Alignment Length:	952	Identity:	214/952 - (22%)
Similarity:	331/952 - (34%)	Gaps:	290/952 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 PPTPSVGKTLLNTSPNLLPITTATDTFNNLKNLVKIDKGSSPSSGSNSLGGNYRKGGSNGSGYKS 167
            |..||..||      ..:.|||.|....|||   |..:....|.|.....|..:|..|.....|.
Yeast   139 PEPPSTPKT------TKIEITTKTGERLNLK---KFHEEKKASKGEEKNDGVEQKSKSGTPFEKE 194

  Fly   168 AGGNGGSPAISGNSEGGRNGSRSSGGPTGHFSTGYSKNS-------VKIRQHDSEVSPRPRRSYQ 225
            |     :|.:..|.......:.:|    ...||..::|:       |::|:...|     |:.
Yeast   195 A-----TPVLPANEAVKDTLTETS----NEKSTSEAENTKRLFLEQVRLRKAAME-----RKK-- 243

  Fly   226 GDSSSSRYYPKNSDILGQGLGGNSDSYNGSSSSGRYQQQDQQGGSHRGSRSNYHSNSDGSY-NRS 289
                                       ||..|....:|:           ::.|.|:|.:. |..
Yeast   244 ---------------------------NGLISETEKKQE-----------TSNHDNTDTTKPNSV 270

  Fly   290 INSNSV------GGGGSGAVGSGSGGSNYRSARNY-------------ENGNGSNGTQPRYG--- 332
            |.|..:      .|..:..|..|..|::.::.::.             ||.:.|........
Yeast   271 IESEPIKEAPKPTGEANEVVIDGKSGASVKTPQHVTGSVTKSVTFNEPENESSSQDVDELVKDDD 335

  Fly   333 ----SGNGNGNSSNSNSSSGYNGSAASSTNSKSSYGASRG--------------GNDGGVSSGYS 379
                |....|.:.|.:.....|....:..|:......|..              |....:|..|.
Yeast   336 TTEISDTTGGKTVNKSDDETINSVITTEENTVKETEPSTSDIEMPTVSQLLETLGKAQPISDIYE 400

  Fly   380 SNYRDNYE------DSPS-HQRYNNTNSLE-------RNGGGGSGAGASG--GPRSYGRS---DA 425
            ..|.:|.|      ..|| ...|..|..|:       |.......|.:|.  .|....|:   |:
Yeast   401 FAYPENVERPDIKYKKPSVKYTYGPTFLLQFKDKLKFRPDPAWVEAVSSKIVIPPHIARNKPKDS 465

  Fly   426 DRYGGTPSSRTPNLR--NGSASAQISGSTSNSSNISLNSGSASAAGGGTPHSQQQQERS------ 482
            .|:||  ..|:|::|  :.::|:::|     |...|...|....:..|.. |::.:|::
Yeast   466 GRFGG--DFRSPSMRGMDHTSSSRVS-----SKRRSKRMGDDRRSNRGYT-SRKDREKAAEKAEE 522

  Fly   483 QAGKASTPP--PITGRWIPPS--------LRPQHGLTQSEKNDAVFRRVRGILNKLTPEKFQELS 537
            ||.|....|  |...||||.|        |.|. |.|:....:.|.|:::.:|||||.|.|..:|
Yeast   523 QAPKEEIAPLVPSANRWIPKSRVKKTEKKLAPD-GKTELFDKEEVERKMKSLLNKLTLEMFDSIS 586

  Fly   538 DELLKLDLNSI-----AILKGVILLIFDKALDEPKYSSMYAQLCKRLSEEA-PSF-DKE---PSN 592
            .|:|.:...|.     ..||.||..||.||.|||.:||||||||.::.::. |:. |||   .:.
Yeast   587 SEILDIANQSKWEDDGETLKIVIEQIFHKACDEPHWSSMYAQLCGKVVKDLDPNIKDKENEGKNG 651

  Fly   593 SSTFLRLLIAVCRDKFN----NRLKRDENDNRPPPENEADEEERRHLAKQRMLGNVKFIGELNKL 653
            ....|..|:|.|.::|.    ::|...|:.|...||..:||......||:|.||.|:|||.|..|
Yeast   652 PKLVLHYLVARCHEEFEKGWADKLPAGEDGNPLEPEMMSDEYYIAAAAKRRGLGLVRFIGYLYCL 716

  Fly   654 DMLSKNVLHQCIMELFDKKKKRTAGTQEMCEDMECLAQLLKTCGKNLDSE---------QGKELM 709
            ::|:..::.:|...|.     :........|.:|.:.:||.|.|:..:.:         :|..|:
Yeast   717 NLLTGKMMFECFRRLM-----KDLNNDPSEETLESVIELLNTVGEQFEHDKFVTPQATLEGSVLL 776

  Fly   710 NQYFEKLERRSKSSEYPPRIRFMLKDVIELRQ-NNWVPRKLGTTEGPVPIKQIRSDDDSIIRTPF 773
            :..|..|:..........||:|.|.||.|||: .:|...|  ...||..|:||..:::.:
Yeast   777 DNLFMLLQHIIDGGTISNRIKFKLIDVKELREIKHWNSAK--KDAGPKTIQQIHQEEEQL----- 834

  Fly   774 PNRNRDMRNNDRDSDSWMNRFHLNIQPGGYNDMFSGLSVTGASPIVSPFATSNRDRDRDNRQYNN 838
                                                                   |.:.|.|.:|
Yeast   835 -------------------------------------------------------RQKKNSQRSN 844

  Fly   839 RGDRNRDRDQGGSGGANYGNRYNKHNQNGGGSGGGSSNNRDRDDSRRNNDRDRDRNDGQYGGNQL 903
                               :|:|.|||:  .|...|||.|:..:::|  |.......|.:..||
Yeast   845 -------------------SRFNNHNQS--NSNRYSSNRRNMQNTQR--DSFASTKTGSFRNNQ- 885

  Fly   904 LGSKELAPRFKRNLITTNQDAVENLQMRPAANSLLFRAASQN 945
                            .|...||.:...|.||  :|.|...|
Yeast   886 ----------------RNARKVEEVSQAPRAN--MFDALMNN 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAT1	NP_001033943.2	MIF4G	518..743	CDD:280935	80/248 (32%)
		RAM	<817..865	CDD:291966	7/47 (15%)
		MA3	1128..1241	CDD:214714
		W2_eIF4G1_like	1314..1460	CDD:211397
TIF4632	NP_011466.1	eIF_4G1	381..440	CDD:403394	12/58 (21%)
TIF4632	NP_011466.1	MIF4G	567..808	CDD:397130	79/245 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346060
Domainoid	1	1.000	107	1.000	Domainoid score	I1435
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004422
OrthoInspector	1	1.000	-	-		mtm9230
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940