DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAT1 and eIFiso4G1

DIOPT Version :9

Sequence 1:	NP_001033943.2	Gene:	NAT1 / 46020	FlyBaseID:	FBgn0010488	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	NP_851207.1	Gene:	eIFiso4G1 / 835897	AraportID:	AT5G57870	Length:	780	Species:	Arabidopsis thaliana

Alignment Length:	948	Identity:	225/948 - (23%)
Similarity:	365/948 - (38%)	Gaps:	278/948 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 RYGSGNGN---GNSSNSNSSSGYNGSAASST--------NSKSSYGASRGGN---DGGVSSGYSS 380
            |.|.|.||   |:||:|:|.|  .||.:||.        .:.:|....:||:   ||.....|:.
plant    12 RPGGGRGNRLFGSSSSSSSLS--FGSLSSSDLPLLRPHGGAPASSFPFKGGDSRFDGRERVKYTR 74

  Fly   381 ----NYRDNYEDSPSHQRYNNTNSLERNGGGGSGA-GASGGPRSYGRSDADRYGGTPSSRTPNLR 440
                ..::..:.|....|.....:.|..|..|:.| |.|..........|.|: ..|.||  :.|
plant    75 EQLLELKETTQLSDEILRVQRETAAELFGEEGTWARGESVVSNLVPVQSASRF-SEPDSR--DWR 136

  Fly   441 NGSASAQISGSTSNSSNISLNSGSASAAGGGTPHSQQQQERSQAGKAST-------PPPITGRWI 498
            :.|.....||...:..|  |.....|.....:.:::|.|..||..:|:.       |.|:..:..
plant   137 SRSTQPPPSGEERSWDN--LREAKDSRYVEASQYNRQDQPNSQFSRANISSNQGGGPAPVLVKAE 199

  Fly   499 PPSLRPQHGLTQSEKNDAVFRRVRGILNKLTPEKFQELSDELLKLDLNSIAILKGVILLIFDKAL 563
            .|....:..|::   ||.|.:.|:||||||||||:..|..:|::..:.|..||||||.||||||:
plant   200 VPWSARRGNLSE---NDRVLKTVKGILNKLTPEKYDLLKGQLIESGITSADILKGVITLIFDKAV 261

  Fly   564 DEPKYSSMYAQLCKRLSEEAPSF-DKEPSNSS-TFLRLLIAVCRDKFNNRLK-RDENDNRPPPEN 625
            .||.:..|||:||..::::.|:| ..||.:.. ||.|:|:.:|::.|....: |:|......|:.
plant   262 LEPTFCPMYAKLCSDINDQLPTFPPAEPGDKEITFKRVLLNICQEAFEGASQLREELRQMSAPDQ 326

  Fly   626 EADEEERRHLAKQRMLGNVKFIGELNKLDMLSKNVLHQCIMELFDKKKKRTAGTQEMC---EDME 687
            ||:..::..|.|.:.|||::.||||.|..|:.:.::|..:.||....:|       :|   |::|
plant   327 EAERNDKEKLLKLKTLGNIRLIGELLKQKMVPEKIVHHIVQELLGADEK-------VCPAEENVE 384

  Fly   688 CLAQLLKTCGKNLDSE-QGKELMNQYFEKLERRSKSSEYPPRIRFMLKDVIELRQNNWVPRKLGT 751
            .:....||.||.||.. :.|.:.:.||::|:..||:.:...|:|||::::|::|.|.||||:
plant   385 AICHFFKTIGKQLDGNVKSKRINDVYFKRLQALSKNPQLELRLRFMVQNIIDMRSNGWVPRR--- 446

  Fly   752 TEGPVPIKQIRSDDDSIIRTPFPNRNRDMRNNDRDSDSWMNRFHLNIQPGGYNDMFSGLSVTGAS 816
                   :::::...:.|.|       :...|            |.::||...:|..|: |:...
plant   447 -------EEMKARTITEIHT-------EAEKN------------LGLRPGATANMRRGM-VSSGG 484

  Fly   817 PIVSPFATSNRDRDRDNRQYNNRGDRNRDRDQGGSGGANYGNRYNKHNQNGGGSGGGSSNNR--- 878
            | |||....                      .||..||             ||...|....|
plant   485 P-VSPGPVY----------------------PGGRPGA-------------GGLMPGMPGTRRMP 513

  Fly   879 -----DRDDSRRNNDRDRDRNDGQYGGNQLLGSKELAPRFKRNLITTNQDAVENLQMRPAANSLL 938
                 |.|:......|...|.||.                                 .|..:..:
plant   514 GMPGVDNDNWEVPRTRSMSRRDGP---------------------------------GPLHSPAV 545

  Fly   939 FRAASQNQKFPATLPMSTPPNSSGSNNQGSSQGQLSNSHYPMLGTPTSHLINPTRPSSTPSAEYA 1003
            .::||.|.:.   ||            |||| |.:|..        ||.|:
plant   546 SKSASMNTRL---LP------------QGSS-GIMSGK--------TSALL-------------- 572

  Fly  1004 DNRTLLGVQQERGLKATSSSPNFSSGAEKLDLDGQAGRKGSHDGKDQGKNGSVERPST-----PA 1063
                                                          || :|||.||.|     ||
plant   573 ----------------------------------------------QG-SGSVSRPVTVSAERPA 590

  Fly  1064 GGIGSAK-----QQKKDKGP--NKEELSKKA----SQYFKDRFYYDEEEDAEVTEIEIKDIDETK 1117
            ..:....     ::.:..||  ::|.|.:|.    .:||..|...:..:..|  |:.:.......
plant   591 QSVAPLTVPVPVEKPQPSGPKLSEEVLQRKTKSLLEEYFNVRLLGEALQCVE--ELGLPSYHPEF 653

  Fly  1118 TEEADAAPVEVSEVKEDAAIPVTTPDRFTKLVDGFLELKLPEK--ALKDVCINLLM--EVLDRVN 1178
            .:||.:..:|.|.       ||..|      :...||..|.:|  |.||:....|:  .:||.:.
plant   654 VKEAISLSLEKSP-------PVVEP------IATLLEYLLSKKVVAPKDLETGFLLYGAMLDDIG 705

  Fly  1179 DVFLERAVRLLQTLRKQSNIKPNIVVEIFKQVVNKMNE 1216
             :.|.:|......:..:..:...:..::.::::.||.:
plant   706 -IDLPKAPNNFGEIVGKLILAGGVDFKLVREIIGKMED 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAT1	NP_001033943.2	MIF4G	518..743	CDD:280935	84/231 (36%)
		RAM	<817..865	CDD:291966	8/47 (17%)
		MA3	1128..1241	CDD:214714	18/93 (19%)
		W2_eIF4G1_like	1314..1460	CDD:211397
eIFiso4G1	NP_851207.1	MIF4G	216..440	CDD:397130	84/230 (37%)
		PHA03247	<469..610	CDD:223021	48/295 (16%)
		MA3	617..729	CDD:397128	26/127 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	154	1.000	Domainoid score	I1351
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	1	1.000	-	-		FOG0004422
OrthoInspector	1	1.000	-	-		otm2499
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23253
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4221
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.020