DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAT1 and eif4g3a

DIOPT Version :9

Sequence 1:	NP_001033943.2	Gene:	NAT1 / 46020	FlyBaseID:	FBgn0010488	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	XP_009304364.1	Gene:	eif4g3a / 566131	ZFINID:	ZDB-GENE-120810-2	Length:	1714	Species:	Danio rerio

Alignment Length:	1286	Identity:	311/1286 - (24%)
Similarity:	496/1286 - (38%)	Gaps:	392/1286 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 QPRYGSGNGNGNSSNSNSSSGYNGSAASSTNSKSSYGASRGG--------NDGGVSSGYSSNY-R 383
            |.::...||     .:.:....||....||:|..:.|.|||.        .:|.|.|.....| |
Zfish   696 QEKHSEENG-----ETETEPFRNGVETESTDSGVTLGDSRGSMCSPTPLIQEGLVQSNGKRQYDR 755

  Fly   384 D---NYEDSPSHQR--------------YNNTNSLERNGGGGSGAGASGGPRSYGRSDADRYGGT 431
            |   .::..|:..:              ..|.|.|...         |..||...|       ||
Zfish   756 DFLLGFQFMPACVQKPEGLPPISDVVLDKMNQNKLPLR---------SVDPRLISR-------GT 804

  Fly   432 PSSRTPNLRNGSASAQISG-------------------STSNSSNISLNSGSASAAGGGTPHSQQ 477
            |...||..  ...|.|::|                   :.|.|.::.|.    .|.....|..::
Zfish   805 PQDFTPAF--ADFSRQMAGGRGAPLLNVRRLPPRKIIVNLSVSDDVQLK----KAENAWKPGMKR 863

  Fly   478 QQERSQAGKASTPPPITGRWIPPSLRPQHGLTQSEKNDAVFRRVRGILNKLTPEKFQELSDELLK 542
            :      |.|..|..|                   :...:||:||.|||||||:.|.:|..::..
Zfish   864 E------GVAEDPETI-------------------RTQELFRKVRSILNKLTPQMFHQLMKQVTD 903

  Fly   543 LDLNSIAILKGVILLIFDKALDEPKYSSMYAQLCKRLSE-EAPSFDKEPSNSSTFLRLLIAVC-- 604
            |.:|:...|||||.|:|:||:|||.:|..||.:|:.|:. :.|:.|| |:.:..|.:||:..|
Zfish   904 LTINTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLATLKVPTADK-PNTTVNFRKLLLNRCQK 967

  Fly   605 ---RDKFNN----RLKRDENDNRPPPENE---ADEEERRHLAKQRMLGNVKFIGELNKLDMLSKN 659
               |||.::    |.:::.:....|.|.|   .:.||.:..|::|..||:||||||.||.||::.
Zfish   968 EFERDKVDDVVLERKQKEIDSATSPTEKERLQEELEEAKDKARRRSTGNIKFIGELFKLKMLTEP 1032

  Fly   660 VLHQCIMELFDKKKKRTAGTQEMCEDMECLAQLLKTCGKNLDSEQGKELMNQYFEKLERRSKSSE 724
            ::|.|:::|......         |.:|||.:||.|.||:||.|:.|..|:|||.::|:..|..:
Zfish  1033 IMHDCVVKLLKNHDD---------ESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK 1088

  Fly   725 YPPRIRFMLKDVIELRQNNWVPRKLGTTEGPVPIKQIRSD-----------------DDSIIRTP 772
            ...||||||:|||:||.:|||.|:  ..:||..|:||..:                 ...:.|.|
Zfish  1089 TSSRIRFMLQDVIDLRLHNWVSRR--ADQGPKTIEQIHKEAKLEEQEEQRKVHQQLLSKDMKRRP 1151

  Fly   773 FPNRNRDMRNNDRDSDSWMNRFHLNIQPGGYNDMFSGLSVTGASPIVSP--FATSNRDRDRDNRQ 835
            .....|.||     .::|      |..|           .|..|..:.|  ....::.:..:..|
Zfish  1152 DQREQRSMR-----EETW------NTVP-----------TTKNSRTIDPTKIPKISKPQIDEKIQ 1194

  Fly   836 YNNRGDRNRDRDQGGSGGA---------NYGNRYNKHN--QNGGGSGGGSSNNRDRDDSRRNNDR 889
            ...|...|..:  |.||||         :.||..|:::  |:.......:.......:|||:
Zfish  1195 LGPRAQINWVK--GSSGGAKASDSELTRSAGNTLNRYSALQSSTSQSSSTPAQTSESESRRS--- 1254

  Fly   890 DRDRNDGQYGGNQLLGSKELAPRFKRNLITTNQDAVENLQMRPAANSLLFRAASQNQKFPATLPM 954
                          |||:....|                              .:::|     |:
Zfish  1255 --------------LGSRGSMGR------------------------------ERSEK-----PV 1270

  Fly   955 STPPNSSGSNNQGSSQGQLSNSHYPMLGTPTSHLINPTRPSSTPSAEYADNRTLLGVQQERGLKA 1019
            |..|:..|...:|||..:|:::..|          ..||                    ..|..:
Zfish  1271 SLGPSRPGPFGRGSSAKELTDNMVP----------EETR--------------------REGQDS 1305

  Fly  1020 TSSSPNFSSGAEKLDLDGQAGRKGSHDGKDQGKNGSVERPSTPAGGIGSAKQQKKDKGP--NKEE 1082
            ..:|...|...||.:::.....:            ||:..:....|:        .:.|  ::||
Zfish  1306 HHTSRKASISEEKCEMENSRSAE------------SVKSETLLVSGV--------SEKPVLSEEE 1350

  Fly  1083 LSKKASQYFKDRFYYDEEEDAEVTEIEIKDIDETKTEEADAAPVEVSEVKEDAAIPVTTPDRFTK 1147
            :.:|:.....:..:.::.::|....:||        |:.....|.|....|      :|.:|..|
Zfish  1351 IERKSKAIIDEFLHINDYKEAVQCVLEI--------EQPSMLCVFVRMGLE------STLERSQK 1401

  Fly  1148 LVD--GFLELKLPEKAL--KDVCINLLMEVLDRVNDVFLE------RAVRLLQTLRKQSNIKPNI 1202
            ..:  |.|..:|.:|.:  .........|:|::.:|:.::      ....||..|.|:..|
Zfish  1402 AREHMGLLYYQLIQKGILPHSQLYKGFSEMLEQADDMAIDIPFIWLYLAELLSPLLKEGGI---- 1462

  Fly  1203 VVEIFKQVVNKMNEREALNPRIVSLVASLLAKTICE--PALLKLSDIANFTDNGQHYPLFLLVLQ 1265
                        |.||         :.|.|:|.:..  .|.:.||:|           |.||..|
Zfish  1463 ------------NMRE---------LFSELSKPLLPVGRAAILLSEI-----------LHLLCKQ 1495

  Fly  1266 QLVKVIGKDALEEKFRASKVDLMNSLPEADRNKERLAGILEDRKLSF----LYPLLKVQA----- 1321
            ...:.:|     :.:|.|.::..:.|||.    |.|...:...||.|    :.|:....|
Zfish  1496 MSHRKVG-----DLWRESGLNWADFLPEG----EHLPAFISQHKLEFTVSDISPVSPASAKPSLS 1551

  Fly  1322 --EMLKQLQ--------SDPNPNNFYKWIKANVDNKYYKDPGFIQALMTVVVKYVTKETTLADNL 1376
              |:.|||:        ||   ...:.||:||:|........|::||||.:.|...|:.:.:..:
Zfish  1552 PEELFKQLEQLLLEDMSSD---EQIFDWIEANLDESQMSSSPFLRALMTAICKAAVKDESTSCRV 1613

  Fly  1377 DPKEHPEKSVTQKEQQLLENYSQMLQTFLGQNELQLMALYALQTFCYNENFPKGMLCRWFKYLYE 1441
            |      .::.||...:|..|      |....|.||.||||||:.....:.|..:|..:|..||:
Zfish  1614 D------TAIIQKRLPILHKY------FDSDTERQLQALYALQSLIVALDQPPNLLRMFFDCLYD 1666

  Fly  1442 SEIIEEEAFVLWKEEISDKYP----GKGSALFQVNAWLTWLQEAESEDDED 1488
            .::|.|:||..|:   :.|.|    |||.||..|||:.|||:|||.|.:::
Zfish  1667 EDVISEDAFYQWE---TSKDPTEQLGKGVALKSVNAFFTWLREAEEESEDN 1714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAT1	NP_001033943.2	MIF4G	518..743	CDD:280935	96/237 (41%)
		RAM	<817..865	CDD:291966	12/60 (20%)
		MA3	1128..1241	CDD:214714	23/124 (19%)
		W2_eIF4G1_like	1314..1460	CDD:211397	45/160 (28%)
eif4g3a	XP_009304364.1	Med25_SD1	18..172	CDD:288132
		MIF4G	879..1107	CDD:280935	96/237 (41%)
		MA3	1351..1462	CDD:280933	22/124 (18%)
		W2_eIF4G1_like	1550..1685	CDD:211397	44/152 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020