Protein Alignment NAT1 and Eif4g2

DIOPT Version :10

• Sequence 1: NP_001033943.2
• Gene: NAT1 / 46020
• FlyBaseID: FBgn0010488
• Length: 1488
• Species: Drosophila melanogaster
• Sequence 2: NP_001017374.2
• Gene: Eif4g2 / 361628
• RGDID: 1305294
• Length: 906
• Species: Rattus norvegicus
• Alignment Length: 1082
• Identity: 375/1082 - (34%)
• Similarity: 545/1082 - (50%)
• Gaps: 249/1082 - (23%)

  Fly   464 SASAAGGGTPHSQQQQERSQAGKA----STPPPITGRWIPP-SLR------PQHGLTQSEKNDAV 517
            |||:.|||:..:.|...:: ||.:    .||.....:|||. |.|      ..:...:.|::||:
  Rat    14 SASSGGGGSRGAPQHYPKT-AGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAI 77

  Fly   518 FRRVRGILNKLTPEKFQELSDELLKLDLNSIAILKGVILLIFDKALDEPKYSSMYAQLCKRLSEE 582
            ||:|||||||||||||.:|..|||.:.:.|..|||||||||.||||:||||||:|||||.||:|:
  Rat    78 FRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAED 142

  Fly   583 APSFD-----KEP--SNSSTFLRLLIAVCRDKFNNRLKR----DENDNRPPPENEADEEERRHLA 636
            ||:||     .:|  ..|:||.||||:..:|:|.||.:.    |:.:|...||    |||:|.:|
  Rat   143 APNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPE----EEEQRAIA 203

  Fly   637 KQRMLGNVKFIGELNKLDMLSKNVLHQCIMELFDKKKKRTAGTQEMCEDMECLAQLLKTCGKNLD 701
            |.:||||:||||||.|||::.:::||:||..|.:|||:  ...::|.||:|||.|:::|.|..||
  Rat   204 KIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKR--VQLKDMGEDLECLCQIMRTVGPRLD 266

  Fly   702 SEQGKELMNQYFEKLERRSKSSEYPPRIRFMLKDVIELRQNNWVPRKLGTTEGPVPIKQIRSD-- 764
            .|:.|.||:|||.::.....|.|.|.||||:|:|.:|||:::|||||.....||..|.|||.|
  Rat   267 HERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAV 331

  Fly   765 ---------------DDSIIRTPF-PNRNRDMRNNDRDSDSWMNRFHLNIQP-GGYNDMF----- 807
                           :|..:..|| |.|.:    .|||             | ||..|||
  Rat   332 KDLGVFIPAPMAQGRNDFFLEGPFMPPRMK----MDRD-------------PLGGLADMFGQMPG 379

  Fly   808 SGLSVTGASPIVSPFATSNRDRDRDNRQYNNRG------DRNRDRDQGGSGGANYGNRYNKHNQN 866
            ||:. ||...|...|:.: ..|.|.|:.:|..|      .:::..:.||....:.|.....|||:
  Rat   380 SGIG-TGPGVIQDRFSPT-MGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQS 442

  Fly   867 GGGSGGGSSNNRDRDDSRRNNDRDRDRNDGQYGGNQLLG-SKELAPRFKRNLITTNQDAVENLQM 930
            .|..                              :||.| ||::.|||.:.    .|...:.:.:
  Rat   443 QGLL------------------------------SQLQGQSKDMPPRFSKK----GQLNADEISL 473

  Fly   931 RPAANSLLFRAASQNQKFPATLPMST--PPNSSGSNNQGSSQGQLSNSHYPMLGTPTSHLINPTR 993
            |||.:.|:    ::|| .|...|..|  ||::.....|....||.     |.||..|    ||.
  Rat   474 RPAQSFLM----NKNQ-VPKLQPQITMIPPSAQPPRTQTPPLGQT-----PQLGLKT----NPP- 523

  Fly   994 PSSTPSAEYADNRTLLGVQQERGLKATSSSPNFSSGAEKLDLDGQAGRKGSHDGKDQGKNGSVER 1058
                             :.||:..|.:...|
  Rat   524 -----------------LIQEKPAKTSKKPP---------------------------------- 537

  Fly  1059 PSTPAGGIGSAKQQKKDKGPNKEELSKKASQYFKDRFYYDEEEDAEVTEIEIKDIDETKTEEADA 1123
                               |:||||.|..              :|.|||.    ::.....:|
  Rat   538 -------------------PSKEELLKLT--------------EAVVTEY----LNSGNANDA-- 563

  Fly  1124 APVEVSEVKEDAAIPVTTPDRFTKLVDGFLELKLPEKALKDVCINLLMEVLDRVNDVFLERAVRL 1188
                                     |.|..|::.|:..|.::...:::..||| :|...|:|..|
  Rat   564 -------------------------VSGVREMRAPKHFLPEMLSKVIILSLDR-SDEDKEKASSL 602

  Fly  1189 LQTLRKQSNIKPNIVVEIFKQVVNKMNEREALNPRIVSLVASLLAKTICEPALLKLSDIANFTDN 1253
            :..|:::.....:..::.|..|:.:..:.|...|.:.|.:|...|:.|.. .|:.:|::|...::
  Rat   603 ISLLKQEGIATSDNFMQAFLNVLEQCPKLEVDIPLVKSYLAQFAARAIIS-ELVSISELAQPLES 666

  Fly  1254 GQHYPLFLLVLQQLVKVIGKDALEEKFRASKVDLMNSLPEADRNKERLAGILEDRKLSFLYPLLK 1318
            |.|:|||||.||||.|:..::.|.|.|:.|||::...|||.|:||:|:..|||.:.||||:||||
  Rat   667 GTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLK 731

  Fly  1319 VQAEMLKQLQSDPNPNNFYKWIKANVDNKYYKDPGFIQALMTVVVKYVTKETT-LADNLDPKEHP 1382
            ::.|:|||::.||:|...|||||.|:..|.:.|.||:..|||..::|::.|.: .:|..|....|
  Rat   732 LEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVSPPSDETDSSSAP 796

  Fly  1383 EKSVTQKEQQLLENYSQMLQTFLGQN-ELQLMALYALQTFCYNENFPKGMLCRWFKYLYESEIIE 1446
            .|...::|:|||.::..::|.||..: :||:.||||||..|||.:||||||.|:|.:.|:.||||
  Rat   797 SKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSSFPKGMLLRFFVHFYDMEIIE 861

  Fly  1447 EEAFVLWKEEISDKYPGKGSALFQVNAWLTWLQEAESEDDED 1488
            ||||:.|||:|:.::||||.||||||.|||||:.||.|:.|:
  Rat   862 EEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEE 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAT1	NP_001033943.2	MIF4G	518..743	CDD:397130	124/235 (53%)
		RAM	<817..860	CDD:464643	10/48 (21%)
		MA3	1128..1241	CDD:214714	21/112 (19%)
		W2_eIF4G1_like	1314..1460	CDD:211397	69/147 (47%)
Eif4g2	NP_001017374.2	MIF4G	78..308	CDD:397130	124/235 (53%)
		PRK12757	<435..>542	CDD:237191	39/225 (17%)
		MA3	543..656	CDD:214714	29/159 (18%)
		W2_eIF4G1_like	739..875	CDD:211397	62/135 (46%)