Protein Alignment NAT1 and Eif4g1

DIOPT Version :9

• Sequence 1: NP_001033943.2
• Gene: NAT1 / 46020
• FlyBaseID: FBgn0010488
• Length: 1488
• Species: Drosophila melanogaster
• Sequence 2: XP_006521998.1
• Gene: Eif4g1 / 208643
• MGIID: 2384784
• Length: 1601
• Species: Mus musculus
• Alignment Length: 1182
• Identity: 284/1182 - (24%)
• Similarity: 459/1182 - (38%)
• Gaps: 348/1182 - (29%)

  Fly   426 DRYGGTP-----SSRTPNLRNGSASAQISGSTSNSSNISL-NSGSASAAGGGT----------PH 474
            |:...||     .||.|.:..|   ...:.|.:|....:| |.|......||.          |.
Mouse   646 DKANKTPLRQLDPSRLPGINCG---PDFTPSFANLGRPALSNRGPPRGGPGGELPRGPQAGLGPR 707

  Fly   475 SQQQQERSQAGKASTPPPIT---------GRWIPPSLRPQHGLTQSE------KNDAVFRRVRGI 524
            ..||..|.:..|..:...:|         ..|.|.|.|......:.|      |...:|||||.|
Mouse   708 RSQQGPRKETRKIISSVIMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSI 772

  Fly   525 LNKLTPEKFQELSDELLKLDLNSIAILKGVILLIFDKALDEPKYSSMYAQLCKRL-SEEAPSFDK 588
            ||||||:.||:|..::.:|.:::...|||||.|||:||:.||.:|..||.:|:.| :.:.|:.:|
Mouse   773 LNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEK 837

  Fly   589 EPSNSSTFLRLLIAVCRDKFNNRLKRDENDNR--PPPENEADE--------------EERRHLAK 637
             |:.:..|.:||:..|:.:|    ::|::|:.  ...:.|.||              ||.|.:|:
Mouse   838 -PTVTVNFRKLLLNRCQKEF----EKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIAR 897

  Fly   638 QRMLGNVKFIGELNKLDMLSKNVLHQCIMELFDKKKKRTAGTQEMCEDMECLAQLLKTCGKNLDS 702
            :|.|||:||||||.||.||::.::|.|:::|.....:         |.:|||.:||.|.||:||.
Mouse   898 RRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDE---------ESLECLCRLLTTIGKDLDF 953

  Fly   703 EQGKELMNQYFEKLERRSKSSEYPPRIRFMLKDVIELRQNNWVPRKLGTTEGPVPIKQIRSDDDS 767
            .:.|..|:|||.::|:..|..:...||||||:||::|||:|||||:  ..:||..|.||.
Mouse   954 AKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRR--GDQGPKTIDQIH----- 1011

  Fly   768 IIRTPFPNRNRDMRNNDRDSDSWMNRFHLNIQPGGYNDMFSGLSVTGASPIVSPFATSNRDRDRD 832
                             ::::...:|.|:.:|
Mouse  1012 -----------------KEAEMEEHREHIKVQ--------------------------------- 1026

  Fly   833 NRQYNNRGDRNRDRDQGGSGGANYGNRYNKHNQNGGGSGGGSSNNRDRDDSRRNNDRDRDRNDGQ 897
              |...:|.   |:.:||..|..........:..|..:...|..:|..|.||
Mouse  1027 --QLMAKGS---DKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSR------------- 1073

  Fly   898 YGGNQLLGSKELAPRFKRNLITTNQDAVENLQMRPAANSLLFRAASQNQKFPATLPMSTPPNSSG 962
                                                                  |...|.|.|..
Mouse  1074 ------------------------------------------------------LTKITKPGSID 1084

  Fly   963 SNNQ------------GSSQGQLSNSHYPMLGTPTSHLINPTRPSS---------TPSAEYADNR 1006
            ||||            |||.|..:.        |:......|||::         |..||..|||
Mouse  1085 SNNQLFAPGGRLSWGKGSSGGSGAK--------PSDTASEATRPATLNRFSALQQTLPAENTDNR 1141

  Fly  1007 TLL---GVQQERGLKATSSSPNFSSGAEKLDLDGQAGRKGSHDGKDQGKNGSVERPSTPAGGIGS 1068
            .::   .:.:|||.||       ....::|:...:.|.:|..          ::|..|||
Mouse  1142 RVVQRSSLSRERGEKA-------GDRGDRLERSERGGDRGDR----------LDRARTPA----- 1184

  Fly  1069 AKQQKKDKGPNKEELSKKASQYFKDRFYYDE--EEDAEVTEIEIKDIDETKTEEADAAPVEVSEV 1131
                      .|...||:..:..::|....|  .:.|.:||...:|                 .|
Mouse  1185 ----------TKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRD-----------------PV 1222

  Fly  1132 KEDAAIPVTTPDRFTKLVDGFLELKLPEKALKDVCINL--LMEVLDRVND--------VF----- 1181
            |.:|.:|..:|.:....||   |::...||:.:..::|  :.|.:..|.:        :|
Mouse  1223 KREATLPPVSPPKAALSVD---EVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGI 1284

  Fly  1182 ---LERAV-------RLLQTLRKQSNIKPNIVVEIFKQVVNKMNEREALNPRIVSLVASLLAKTI 1236
               |||:.       |||..|....::......:...:.:....:.|...|.:...:|.|:...:
Mouse  1285 ESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPIL 1349

  Fly  1237 CEPALLKLSDIANFT----DNGQHYPLFLLVLQQLVKVIGKDALEEKFRASKVDLMNSLPE---- 1293
            .|..:.........|    ..|:...|.|.:|..|.|.:|...:...:|.:.:.....|.|
Mouse  1350 QEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDV 1414

  Fly  1294 ----ADRNKERLAGILED----RKLSFLYPLLKVQAEMLKQLQSDPNPNNFYKWIKANVDNKYYK 1350
                |::..|...|...:    |.|:|    .:::.::.|.|:...:....:.||.||::.:...
Mouse  1415 GSFVAEKKVEYTLGEESEAPGQRTLAF----EELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIA 1475

  Fly  1351 DPGFIQALMTVV-VKYVTKETTLADNLDPKEHPEKSVTQKEQQLLENYSQMLQTFLGQNELQLMA 1414
            ....::||||.| ...:..||.|               :.:.|:|:..:::||.:|...:.:|.|
Mouse  1476 SNTLVRALMTTVCYSAIIFETPL---------------RVDVQVLKVRARLLQKYLCDEQKELQA 1525

  Fly  1415 LYALQTFCYNENFPKGMLCRWFKYLYESEIIEEEAFVLWKEEISDKYP----GKGSALFQVNAWL 1475
            |||||........|..:|..:|..||:.::::|:||..|:   |.|.|    |||.||..|.|:.
Mouse  1526 LYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWE---SSKDPAEQQGKGVALKSVTAFF 1587

  Fly  1476 TWLQEAESEDDE 1487
            .||:|||.|:.:
Mouse  1588 NWLREAEDEESD 1599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAT1	NP_001033943.2	MIF4G	518..743	CDD:280935	96/241 (40%)
		RAM	<817..865	CDD:291966	6/47 (13%)
		MA3	1128..1241	CDD:214714	26/137 (19%)
		W2_eIF4G1_like	1314..1460	CDD:211397	36/146 (25%)
Eif4g1	XP_006521998.1	PHA03247	<4..463	CDD:223021
		rad2	<373..>612	CDD:273166
		MIF4G	766..994	CDD:367217	96/241 (40%)
		MA3	1243..1355	CDD:367215	18/111 (16%)
		W2_eIF4G1_like	1442..1571	CDD:211397	37/146 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020