DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAT1 and EIF4G2

DIOPT Version :9

Sequence 1:	NP_001033943.2	Gene:	NAT1 / 46020	FlyBaseID:	FBgn0010488	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	NP_001166176.1	Gene:	EIF4G2 / 1982	HGNCID:	3297	Length:	907	Species:	Homo sapiens

Alignment Length:	1072	Identity:	376/1072 - (35%)
Similarity:	548/1072 - (51%)	Gaps:	228/1072 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   464 SASAAGGGTPHSQQQQERSQAGKA----STPPPITGRWIPP-SLR------PQHGLTQSEKNDAV 517
            |||:.|||:..:.|...:: ||.:    .||.....:|||. |.|      ..:...:.|::||:
Human    14 SASSGGGGSRGAPQHYPKT-AGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAI 77

  Fly   518 FRRVRGILNKLTPEKFQELSDELLKLDLNSIAILKGVILLIFDKALDEPKYSSMYAQLCKRLSEE 582
            ||:|||||||||||||.:|..|||.:.:.|..|||||||||.||||:||||||:|||||.||:|:
Human    78 FRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAED 142

  Fly   583 APSFD-----KEP--SNSSTFLRLLIAVCRDKFNNRLKR----DENDNRPPPENEADEEERRHLA 636
            ||:||     .:|  ..|:||.||||:..:|:|.||.:.    |:.:|...||    |||:|.:|
Human   143 APNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPE----EEEQRAIA 203

  Fly   637 KQRMLGNVKFIGELNKLDMLSKNVLHQCIMELFDKKKKRTAGTQEMCEDMECLAQLLKTCGKNLD 701
            |.:||||:||||||.|||::.:::||:||..|.:|||:  ...::|.||:|||.|:::|.|..||
Human   204 KIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKR--VQLKDMGEDLECLCQIMRTVGPRLD 266

  Fly   702 SEQGKELMNQYFEKLERRSKSSEYPPRIRFMLKDVIELRQNNWVPRKLGTTEGPVPIKQIRSD-- 764
            .|:.|.||:|||.::.....|.|.|.||||:|:|.:|||:::|||||.....||..|.|||.|
Human   267 HERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAV 331

  Fly   765 DDSIIRTPFPNRNRDMRNNDRDSDSWMN------RFHLNIQP-GGYNDMF-----SGLSVTGASP 817
            .|..:..|.| ..:.||     ||.::.      |..::..| ||..|||     ||:. ||...
Human   332 KDLGVFIPAP-MAQGMR-----SDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIG-TGPGV 389

  Fly   818 IVSPFATSNRDRDRDNRQYNNRG------DRNRDRDQGGSGGANYGNRYNKHNQNGGGSGGGSSN 876
            |...|:.: ..|.|.|:.:|..|      .:::..:.||....:.|.....|||:.|..
Human   390 IQDRFSPT-MGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLL------ 447

  Fly   877 NRDRDDSRRNNDRDRDRNDGQYGGNQLLG-SKELAPRFKRNLITTNQDAVENLQMRPAANSLLFR 940
                                    :||.| ||::.|||.:.    .|...:.:.:|||.:.|:
Human   448 ------------------------SQLQGQSKDMPPRFSKK----GQLNADEISLRPAQSFLM-- 482

  Fly   941 AASQNQKFPATLPMST--PPNSSGSNNQGSSQGQLSNSHYPMLGTPTSHLINPTRPSSTPSAEYA 1003
              ::|| .|...|..|  ||::.....|....||.     |.||..|    ||.
Human   483 --NKNQ-VPKLQPQITMIPPSAQPPRTQTPPLGQT-----PQLGLKT----NPP----------- 524

  Fly  1004 DNRTLLGVQQERGLKATSSSPNFSSGAEKLDLDGQAGRKGSHDGKDQGKNGSVERPSTPAGGIGS 1068
                   :.||:..|.:...|
Human   525 -------LIQEKPAKTSKKPP-------------------------------------------- 538

  Fly  1069 AKQQKKDKGPNKEELSKKASQYFKDRFYYDEEEDAEVTEIEIKDIDETKTEEADAAPVEVSEVKE 1133
                     |:||||.|..              :..|||.    ::.....||
Human   539 ---------PSKEELLKLT--------------ETVVTEY----LNSGNANEA------------ 564

  Fly  1134 DAAIPVTTPDRFTKLVDGFLELKLPEKALKDVCINLLMEVLDRVNDVFLERAVRLLQTLRKQSNI 1198
                           |:|..|::.|:..|.::...:::..||| :|...|:|..|:..|:::...
Human   565 ---------------VNGVREMRAPKHFLPEMLSKVIILSLDR-SDEDKEKASSLISLLKQEGIA 613

  Fly  1199 KPNIVVEIFKQVVNKMNEREALNPRIVSLVASLLAKTICEPALLKLSDIANFTDNGQHYPLFLLV 1263
            ..:..::.|..|:::..:.|...|.:.|.:|...|:.|.. .|:.:|::|...::|.|:|||||.
Human   614 TSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIIS-ELVSISELAQPLESGTHFPLFLLC 677

  Fly  1264 LQQLVKVIGKDALEEKFRASKVDLMNSLPEADRNKERLAGILEDRKLSFLYPLLKVQAEMLKQLQ 1328
            ||||.|:..::.|.|.|:.|||::...|||.|:||:|:..|||.:.||||:||||::.|:|||::
Human   678 LQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIK 742

  Fly  1329 SDPNPNNFYKWIKANVDNKYYKDPGFIQALMTVVVKYVTKETT-LADNLDPKEHPEKSVTQKEQQ 1392
            .||:|...|||||.|:..|.:.|.||:..|||..::|::.|.. .:|..|....|.|...::|:|
Human   743 LDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQ 807

  Fly  1393 LLENYSQMLQTFLGQN-ELQLMALYALQTFCYNENFPKGMLCRWFKYLYESEIIEEEAFVLWKEE 1456
            ||.::..::|.||..: :||:.||||||..|||.|||||||.|:|.:.|:.||||||||:.|||:
Human   808 LLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKED 872

  Fly  1457 ISDKYPGKGSALFQVNAWLTWLQEAESEDDED 1488
            |:.::||||.||||||.|||||:.||.|:.|:
Human   873 ITQEFPGKGKALFQVNQWLTWLETAEEEESEE 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAT1	NP_001033943.2	MIF4G	518..743	CDD:280935	124/235 (53%)
		RAM	<817..865	CDD:291966	11/53 (21%)
		MA3	1128..1241	CDD:214714	21/112 (19%)
		W2_eIF4G1_like	1314..1460	CDD:211397	70/147 (48%)
EIF4G2	NP_001166176.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		16/57 (28%)
		MIF4G	78..308	CDD:280935	124/235 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..541		16/122 (13%)
		MA3	544..657	CDD:214714	29/159 (18%)
		W2_eIF4G1_like	740..876	CDD:211397	63/135 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158753
Domainoid	1	1.000	225	1.000	Domainoid score	I2544
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	564	1.000	Inparanoid score	I1084
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D537108at33208
OrthoFinder	1	1.000	-	-		FOG0004422
OrthoInspector	1	1.000	-	-		oto89791
orthoMCL	1	0.900	-	-		OOG6_107094
Panther	1	1.100	-	-	O	PTHR23253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4221
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.900