DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAT1 and eif4g3

DIOPT Version :9

Sequence 1:	NP_001033943.2	Gene:	NAT1 / 46020	FlyBaseID:	FBgn0010488	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	XP_031760741.1	Gene:	eif4g3 / 100216088	XenbaseID:	XB-GENE-1010293	Length:	1740	Species:	Xenopus tropicalis

Alignment Length:	1363	Identity:	316/1363 - (23%)
Similarity:	506/1363 - (37%)	Gaps:	411/1363 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 ENGNGSNGTQPRYGSGNGNGNSSNSNSSSGYNGSAASSTNSKSSYGASRGG------------ND 371
            |..:|...|....|.|.|.|.:...:...  :.....|.|||.|...:...            ..
Frog   596 EQEDGRAATLESDGEGQGKGRTEGDSELE--SSVKLLSINSKKSPVEAPAAITAPKMWQKPKDES 658

  Fly   372 GGVSSGYSSNYRDNYEDSPSHQR----------YNNTNSLE---------------------RNG 405
            ..:.....|.....|||.|...:          |:.|:::|                     |||
Frog   659 PDIEEISQSETEPQYEDDPLEDKVTELDQDPVTYSGTSTMEVEQLYLNNAKPQEQNGEVEPIRNG 723

  Fly   406 G-------------------------GGSGAG---------------ASGGPRSYGR-------- 422
            .                         .|.||.               ::.|.|.|.|
Frog   724 ADAVSESEGTDIPSGTEEGLAYPYSKAGIGAAEQPPDPSQEPPAPPQSADGKRQYDRDFLLGFQY 788

  Fly   423 --SDADRYGGTP--------SSRTPNLRNGSASAQISGSTSNSSNISLNSGSASAAGGGTPHSQQ 477
              :...:..|.|        ....|.|...:..|::.....:.:....:.|..:..|.|.|....
Frog   789 MPACVQKPEGLPPISDVVLDKINQPKLPIRALDARMLQRGPDFTPAYADFGRPAPGGRGMPLLSV 853

  Fly   478 QQERSQAGKASTPPPI---------------TGRWIPPSLR---PQHGLTQSEKNDAVFRRVRGI 524
            ...|||.|:...|..|               ...|.|...|   |:.  ..|.:..|:||:||.|
Frog   854 GPRRSQPGQRREPRKIIMNISVSDDVHLKKSENAWKPSVKRDSLPED--PDSIRTQALFRKVRSI 916

  Fly   525 LNKLTPEKFQELSDELLKLDLNSIAILKGVILLIFDKALDEPKYSSMYAQLCKRLSE-EAPSFDK 588
            ||||||:.|.:|..::..|.:::...|||||.|:|:||:|||.:|..||.:|:.|:. :.|..||
Frog   917 LNKLTPQMFNQLMKQVTDLTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLATLKVPMADK 981

  Fly   589 EPSNSSTFLRLLIAVCRDKFNNRLKRDENDN------------RPPPENEA---DE-EERRHLAK 637
             |.::..|.:||:..|:.:|    ::|:.|:            ...||.::   || ||.:..|:
Frog   982 -PGSTVNFRKLLLNRCQKEF----EKDKADDDVFEKKQKDLELATTPEEKSRLQDELEESKDKAR 1041

  Fly   638 QRMLGNVKFIGELNKLDMLSKNVLHQCIMELFDKKKKRTAGTQEMCEDMECLAQLLKTCGKNLDS 702
            :|.:||:||||||.||.||::.::|.|:::|.....:         |.:|||.:||.|.||:||.
Frog  1042 RRSIGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDE---------ESLECLCRLLTTIGKDLDF 1097

  Fly   703 EQGKELMNQYFEKLERRSKSSEYPPRIRFMLKDVIELRQNNWVPRKLGTTEGPVPIKQIRSDDDS 767
            |:.|..|:|||.::|:..|..:...||||||:|||:||.:|||.|:  ..:||..|:||..:
Frog  1098 EKAKPRMDQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLSNWVSRR--ADQGPKTIEQIHKE--- 1157

  Fly   768 IIRTPFPNRNRDMRNNDRDSDSWMNRFHLNIQPGGYNDMFSGLSVTGASPIVSPFATSNRDRDRD 832
                                                                     :..:...:
Frog  1158 ---------------------------------------------------------AKIEEQEE 1165

  Fly   833 NRQYNNRGDRNRDRDQGGSGGANYGNRYNKHNQNGGGSGGGSSNNRDRDDSRRNNDRDRDRNDGQ 897
            .|:......:.:.|..|          ..:.::.|..:..|:.|||..|.|
Frog  1166 QRKVQQLMTKEKRRPAG----------VQRVDEGGWNTVQGAKNNRVLDPS-------------- 1206

  Fly   898 YGGNQLLGSKELAPRFKRNLITTNQDAVENLQMRPAANSLLFRAASQNQKFPATLPMSTPPNSSG 962
                             :.|..|.....|.:|:.|.|.                 |.|....|||
Frog  1207 -----------------KFLKITKPTIDEKIQLVPKAQ-----------------PGSWLKGSSG 1237

  Fly   963 ----SNNQGSSQGQLSNSHYPMLGTPTSHLINPTRPSSTPSAEYADNRTLLGVQQERGLKATSSS 1023
                |..:....|..|.:.:..|..|.|.:.:.:  ||:||.  .|:|.||          |||.
Frog  1238 GAKASETESLRPGAPSLNRFSALQQPLSSVSSSS--SSSPSE--LDSRRLL----------TSSR 1288

  Fly  1024 PNFSSGAEKLDLDGQAGRKGSHDGKDQGKNGSVERPSTPAGGIGSA-------KQQKKDKGPNKE 1081
                         |..||:         ||   ::||.|: .|.||       :...||...|:|
Frog  1289 -------------GSTGRE---------KN---DKPSAPS-SIPSAPRPGTLLRGSSKDSADNQE 1327

  Fly  1082 ELSKKASQYFKDRFYYDEEEDAEVTEIEIKDIDETKTEEADAAPVEVSEVKEDAAIPVTTPDRFT 1146
            ||.::..|..|......|.:...|.|...|:..:::..|.|...:...|:           :|.:
Frog  1328 ELRRETLQTVKQLTNVAEPDKNTVPERRPKEPAKSEPSEPDKPTLSEEEM-----------ERKS 1381

  Fly  1147 K-LVDGFLELKLPEKALKDVCINLLMEVLDRVN---DVFLERAVRLLQTLRKQSNIKPNIVVEIF 1207
            | ::|.||.:...::|::  |:..|     ..|   .||:.:.|   ::..::|.|..:.:.::.
Frog  1382 KAIIDEFLHINDYKEAMQ--CVEEL-----GANGPLSVFVRQGV---ESTLERSQITRDHMGQLL 1436

  Fly  1208 KQVV--NKMNE-------REALN---------PRIVSLVASLLAKTICEPALLKLSDIANF---- 1250
            .|:|  .|:::       .|.|.         |.|...:|.|:...:.|..:.....|..|
Frog  1437 YQLVQSGKLSKLDFFTGFSETLELADDMAIDIPHIWLYLAELVTPMLKEGGISLRELITEFGKAL 1501

  Fly  1251 TDNGQHYPLFLLVLQQLVKVIGKDALEEKFRASKVDLMNSLPEADRNKERLAGILEDRKLSFLYP 1315
            ...|:...|...:|..|.|.:....:...:|.:.:...:.|||.    |.:...:.::.|.|...
Frog  1502 LPVGRGGELLSEILHLLCKQMSHKRVAALWRETGLRWRDLLPEG----EDVQSFVSEKNLEFTLS 1562

  Fly  1316 --------LLK--VQAEMLKQ------LQSDPNPNNFYKWIKANVDNKYYKDPGFIQALMTVVVK 1364
                    |.|  :.||.|.:      :|...|....:.|::|::|......|.|::||||.|.|
Frog  1563 DSSSPSENLSKKEMSAEELHKRLEQLIIQEKANDEQIFDWVEASLDESQMSSPTFLRALMTAVCK 1627

  Fly  1365 YVTKETTLADNLDPKEHPEKSVTQKEQQLLENYSQMLQTFLGQNELQLMALYALQTFCYNENFPK 1429
            ........:..:|        :|..:|::    ..:|:......|.:|.||||||......:.|.
Frog  1628 AAILGDCSSCRVD--------ITFLKQRV----PVLLKYLDSDTERELQALYALQALIVKLDQPP 1680

  Fly  1430 GMLCRWFKYLYESEIIEEEAFVLWKEEISDKYP----GKGSALFQVNAWLTWLQEAESEDDED 1488
            .:|..:|..||:.|:|.|:||..|:   |.|.|    |||.||..|.|:.|||||||.|.:::
Frog  1681 NVLRMFFDCLYDEEVISEDAFYKWE---SSKDPAEQEGKGVALKSVTAFFTWLQEAEEESEDN 1740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAT1	NP_001033943.2	MIF4G	518..743	CDD:280935	95/241 (39%)
		RAM	<817..865	CDD:291966	3/47 (6%)
		MA3	1128..1241	CDD:214714	25/134 (19%)
		W2_eIF4G1_like	1314..1460	CDD:211397	42/161 (26%)
eif4g3	XP_031760741.1	PHA03247	<73..493	CDD:223021
		MIF4G	910..1138	CDD:397130	95/241 (39%)
		MA3	1378..1489	CDD:397128	24/120 (20%)
		W2_eIF4G1_like	1579..1711	CDD:211397	40/146 (27%)
		W2	<1690..1736	CDD:418396	25/48 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23253
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110