Protein Alignment MYB and Myb

DIOPT Version :10

• Sequence 1: XP_054211496.1
• Gene: MYB / 4602
• HGNCID: 7545
• Length: 994
• Species: Homo sapiens
• Sequence 2: NP_511170.1
• Gene: Myb / 32543
• FlyBaseID: FBgn0002914
• Length: 657
• Species: Drosophila melanogaster
• Alignment Length: 837
• Identity: 239/837 - (28%)
• Similarity: 333/837 - (39%)
• Gaps: 298/837 - (35%)

Human   230 LARASVNSAGIILTSIYSSDED--------DEDFEMCDHD------YDGLLP------------- 267
            :|.||..:...::.  |.|:.|        :||.::||.|      .|...|
  Fly     1 MASASTENGEELMN--YGSNSDSEESEYSENEDTQVCDKDSQQNSNADSGYPLDSPELQDSKTTG 63

Human   268 -----KSGKRHLGKT--------RWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQ 319
                 ||||..:|..        ||::.||..||:|||.:| ::|::|..:..:|.:.|.|.||.
  Fly    64 QKGQNKSGKTSIGAVHPNYGFGKRWSKSEDVLLKQLVETHG-ENWEIIGPHFKDRLEQQVQQRWA 127

Human   320 KVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWT 384
            |||||||||||||::||..||:||:.:|||:|::||::|.|||||||||||||||||.:|||:||
  Fly   128 KVLNPELIKGPWTRDEDDMVIKLVRNFGPKKWTLIARYLNGRIGKQCRERWHNHLNPNIKKTAWT 192

Human   385 EEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKASQPAVATS 449
            |:||.||||||..|||:||:|||.||||||||||||||||||||.:.|   :.|..||...:.:|
  Fly   193 EKEDEIIYQAHLELGNQWAKIAKRLPGRTDNAIKNHWNSTMRRKYDVE---RRSVNASGSDLKSS 254

Human   450 FQKNSHLMGFAQAPPTAQLPATGQPTVNNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPAAA 514
               .:||:...::.                    .||:..|             |:.:..:....
  Fly   255 ---RTHLITLIKSG--------------------GISKCMN-------------NMQHNKESGGE 283

Human   515 AIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQ----TQNHTCSYPGWHST-TIADHTRPHGD 574
            |:.:..| .|......:|..:|...|.::..||..    :..|.........| .|...||.|
  Fly   284 AVNKSEN-ADGASVTAVKGGDLAQESQDDHQKGSNLAHLSMQHLIKLTMPRQTPIILKRTRKH-- 345

Human   575 SAPVSCLGEHHSTPSLPADPGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSDSSSW 639
                                  :||..         ||                         :.
  Fly   346 ----------------------IPETH---------HQ-------------------------AG 354

Human   640 CDLSSFEFFEEADFSPSQHHTGKALQLQQREGNGTKPAGEPSPRVNKRMLSESSLDPPKVLPPAR 704
            |  ||.|.|                       |..:.||....|                 ||
  Fly   355 C--SSSETF-----------------------NQEEAAGNARSR-----------------PP-- 375

Human   705 HSTIPLVILRKKRGQASPLATGDCSSFIFADVSSSTPKRSPVKSLPFSPSQFLNTS--SNHENSD 767
                                              |:|..||:||||||||.||.:.  :..|:.|
  Fly   376 ----------------------------------SSPVISPIKSLPFSPSHFLKSPCLTTFEDMD 406

Human   768 LEMPSLTSTPLIGHKLTVTTPFHR-DQTVKTQKENTVFRTPAIKRSILESSPRTPTPFKHALAAQ 831
            |.    .|||       ||..::| ...:|.:.|.:...||  .:|.|  .||||||||.||||.
  Fly   407 LR----ASTP-------VTKVYNRVGMEIKKEMETSSIETP--HKSQL--GPRTPTPFKKALAAI 456

Human   832 EIKYGPLKMLPQTPSHLVEDLQDVIKQE-----------------SDESGIVAEFQENGPPLLKK 879
            ..|....:..|.:||.|||||.::|.:|                 ...|.:..|:....||.:|:
  Fly   457 GKKRDGRRYEPSSPSSLVEDLAEIIHEEHLSNSLTANNSKMMGAADQNSTLSTEYNAQSPPHMKR 521

Human   880 IKQEVESPTDKSGNFFCSHHWE-GDSLNTQLFTQTSPVADAPNILTSSVLMAPASEDEDNVLKAF 943
            .::.:.|      .:..:|.:. |.:...|.|...:|         |..|.:|....:|.:....
  Fly   522 ARKSLLS------TWSSNHPYNAGSAKRIQPFETETP---------SKFLTSPGDILKDTLCSEQ 571

Human   944 TVP------KNRSLAS--------------PLQPCSSTWEPASCGKMEEQMTSSSQA 980
            .:|      :||...:              .:.|   .|...:|||..:||....||
  Fly   572 DLPFDEGRKENRPFHNRRINKYRGGLTYDHVIDP---KWARVACGKSRDQMFMEEQA 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYB	XP_054211496.1	SANT	276..324	CDD:197842	20/55 (36%)
		REB1	325..>438	CDD:227476	81/112 (72%)
		LMSTEN	504..549	CDD:462332	9/44 (20%)
		Cmyb_C	751..910	CDD:462753	53/179 (30%)
Myb	NP_511170.1	Myb_DNA-bind_6	88..147	CDD:372817	31/59 (53%)
		PLN03212	136..>236	CDD:178751	75/99 (76%)
		Cmyb_C	388..>484	CDD:462753	43/110 (39%)