Protein Alignment hlk and MPD2

DIOPT Version :10

• Sequence 1: NP_001163065.1
• Gene: hlk / 46017
• FlyBaseID: FBgn0010482
• Length: 1786
• Species: Drosophila melanogaster
• Sequence 2: NP_014553.1
• Gene: MPD2 / 854065
• SGDID: S000005448
• Length: 277
• Species: Saccharomyces cerevisiae
• Alignment Length: 267
• Identity: 53/267 - (19%)
• Similarity: 88/267 - (32%)
• Gaps: 86/267 - (32%)

  Fly   194 QQCRKCAKALQELENI---DDEADQLGIGFVKIHDEALADEY--NLGNLPALVYYRHQT-PII-- 250
            |.|:..|...:||..:   ....|...|.|::::.|......  :|...|.:...:.:| |::
Yeast    57 QHCKTLAPVYEELGELYAKKANKDDTPINFLEVNCEFFGPTLCTDLPGFPIIELVKPRTKPLVLP 121

  Fly   251 ---------YEGELQREEDVLEWLVQNKSTGDEDDVIEDVTSKTLSTLISNIDNL-----VVLFY 301
                     :|...||   :..|....|...|...|:....|:.|.:|.:.||.:     ...|.
Yeast   122 KLDWSSMKFHERLWQR---IKTWFNNPKYQLDTSRVVRFEGSRNLKSLSNFIDTVRSKDTEERFI 183

  Fly   302 DHGNDDSMTVLEELEQIDDDCDKHGIQFVKIDDAKAAADYGIDSIPAIVYFEKEIPNVYDGDLMD 366
            :|..|||....|||......|             ||..:|..|::..:.           ||:..
Yeast   184 EHIFDDSRNCNEELRSQQLLC-------------KAGKEYYSDTLSKLY-----------GDVNG 224

  Fly   367 EEQILKWLLGQLERDEIEDVTDEMLDTMIKEGRVIAVLFYDNNDKKSQKVLEELE---------- 421
            .|                           ||.|.:..|...|.|..|::|.|:|:
Yeast   225 LE---------------------------KERRRLEALIKQNGDDLSKEVKEKLKIIRLQLSLLS 262

  Fly   422 NIDDECD 428
            :|:|:.:
Yeast   263 HIEDQLE 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hlk	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		ER_PDI_fam	381..>670	CDD:273457	12/58 (21%)
		PDI_a_family	384..479	CDD:239259	12/55 (22%)
		ER_PDI_fam	700..>916	CDD:273457
		PDI_a_family	1129..1226	CDD:239259
		TRX_family	1433..>1502	CDD:239245
MPD2	NP_014553.1	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold	<48..170	CDD:469754	23/115 (20%)