Protein Alignment l(2)01289 and PDI1

DIOPT Version :9

• Sequence 1: NP_001163065.1
• Gene: l(2)01289 / 46017
• FlyBaseID: FBgn0010482
• Length: 1786
• Species: Drosophila melanogaster
• Sequence 2: NP_009887.1
• Gene: PDI1 / 850314
• SGDID: S000000548
• Length: 522
• Species: Saccharomyces cerevisiae
• Alignment Length: 619
• Identity: 122/619 - (19%)
• Similarity: 198/619 - (31%)
• Gaps: 210/619 - (33%)

  Fly   685 VLEW---LLVQKKTATIEEVT--DEILVTL--------INEHEYVVVFFTGPCEPGETCEHTLN- 735
            ||.|   ||.....|..|.|.  |..:|.|        |..|:.|:..|..|     .|.|..|
Yeast     8 VLSWSSLLLASSVFAQQEAVAPEDSAVVKLATDSFNEYIQSHDLVLAEFFAP-----WCGHCKNM 67

  Fly   736 ALESID--DELDEAGIIFV---TTEDTGIAKKYNVKTYPRLVFFRNRD---PLHFTGDLDDEDEV 792
            |.|.:.  :.|.|..|...   .||:..:..::|:..:|.|..|:|.|   .:.:.|....|..|
Yeast    68 APEYVKAAETLVEKNITLAQIDCTENQDLCMEHNIPGFPSLKIFKNSDVNNSIDYEGPRTAEAIV 132

  Fly   793 LAWITDDE-----TLEIPGKIEEVNVKMLDKILAENDHVVVFFYAEGDKKAQKILNELENIDDEC 852
            ...|...:     ..::|..:  .|...:..::.::..:...|.|.....|.|..|
Yeast   133 QFMIKQSQPAVAVVADLPAYL--ANETFVTPVIVQSGKIDADFNATFYSMANKHFN--------- 186

  Fly   853 EEKDIDFV--KTSDDDIDKEYDLPGL---PALAFYRHKFRTIYTGDLMKEEEILEWVIDLHESTA 912
               |.|||  :.:|||......||..   |          .:|.|   |:.:|.:         |
Yeast   187 ---DYDFVSAENADDDFKLSIYLPSAMDEP----------VVYNG---KKADIAD---------A 226

  Fly   913 DVIE------------SVDRKTLQVLINDVEHLAVFFYDDECESCSDILEELENIDDDTDKHG-- 963
            ||.|            .:|.......:.....|...||:||.|     |||.:.:..:..|..
Yeast   227 DVFEKWLQVEALPYFGEIDGSVFAQYVESGLPLGYLFYNDEEE-----LEEYKPLFTELAKKNRG 286

  Fly   964 -IQFVKSNDVKLAHEIGIF----AFPALVYYETGVPIMYDGNIASNQDVFN-----WILEQKADQ 1018
             :.||..:..|.....|..    .||....::....:.| |....:::.|:     .:||.||.:
Yeast   287 LMNFVSIDARKFGRHAGNLNMKEQFPLFAIHDMTEDLKY-GLPQLSEEAFDELSDKIVLESKAIE 350

  Fly  1019 SIQLINRDQLFEYIGTKDFLAVVFYKEDDPDSPRVLRHIELIDDEAAEYGIYIVKMHDKLMAKKY 1083
            |:             .||||        ..|:..:::..|:.:::.:.....:.|.||::
Yeast   351 SL-------------VKDFL--------KGDASPIVKSQEIFENQDSSVFQLVGKNHDEI----- 389

  Fly  1084 GFRNPPGLTYFRKGKYINYDGDIDDEEEVLDWLTSPANMEMTDHIEQVNRKMFEKIRKNSDYVAV 1148
                            :|     |.:::||                                  |
Yeast   390 ----------------VN-----DPKKDVL----------------------------------V 399

  Fly  1149 IFYSDECKQCPRVLAEVEHIDDEADKAGID--FVKIDDKQM-AKEYGVFALPAIVFFKPTSK-EP 1209
            ::|:..|..|.|:....:.:.|....|..|  ..|:|..:. .:...:...|.||.:....| |.
Yeast   400 LYYAPWCGHCKRLAPTYQELADTYANATSDVLIAKLDHTENDVRGVVIEGYPTIVLYPGGKKSES 464

  Fly  1210 VIYAGD----------------------LYEEEQ 1221
            |:|.|.                      ||||.|
Yeast   465 VVYQGSRSLDSLFDFIKENGHFDVDGKALYEEAQ 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259
		Thioredoxin_6	510..689	CDD:404691	3/6 (50%)
		ER_PDI_fam	700..>916	CDD:273457	53/244 (22%)
		PDI_a_family	1129..1226	CDD:239259	23/119 (19%)
		TRX_family	1433..>1502	CDD:239245
PDI1	NP_009887.1	ER_PDI_fam	32..492	CDD:273457	108/587 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910