DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)01289 and TXNDC5

DIOPT Version :9

Sequence 1:	NP_001163065.1	Gene:	l(2)01289 / 46017	FlyBaseID:	FBgn0010482	Length:	1786	Species:	Drosophila melanogaster
Sequence 2:	NP_110437.2	Gene:	TXNDC5 / 81567	HGNCID:	21073	Length:	432	Species:	Homo sapiens

Alignment Length:	403	Identity:	90/403 - (22%)
Similarity:	140/403 - (34%)	Gaps:	112/403 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1289 GGAASAAAAFGSEADPSEAAAGGAEDAPAA-GSEGDSPPASAAAPADAST-GKQEDD------AD 1345
            ||....|.|       .||||..|:..||| |.:|..|.:.....||..| |.|...      |.
Human    30 GGGRWGARA-------QEAAAAAADGPPAADGEDGQDPHSKHLYTADMFTHGIQSAAHFVMFFAP 87

  Fly  1346 GCEQCTKVLEELENIDD---------------DCDKHGITFVKTRDFSVADGYGVHEYPALVYFE 1395
            .|..|.::.....::.|               ||..|.         .|....||..||.|..|:
Human    88 WCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHS---------DVCSAQGVRGYPTLKLFK 143

  Fly  1396 GGIPNV-FEGELSEEEEVLQWLITQKTEDRI------------EL------ITRQMLETMVEETQ 1441
            .|...| ::|. .:.:.:..|::....|:.:            ||      ::....|..|.:..
Human   144 PGQEAVKYQGP-RDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGD 207

  Fly  1442 YLAVYFYKINCNIC-------DQILEGLELIDDECDVFGIHMVKI------QDPQLAKRYSIKTF 1493
            :. :.|:...|..|       :|:..|||..:         .|||      |..:|.....::.:
Human   208 HF-IKFFAPWCGHCKALAPTWEQLALGLEHSE---------TVKIGKVDCTQHYELCSGNQVRGY 262

  Fly  1494 PALVYFRNGNPL--------------LFEGDLQ-NEQSVLEWLIDDDNRELADEIE-------EV 1536
            |.|::||:|..:              ..|..|| .|....|.:...:...||.|.|       .:
Human   263 PTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLAL 327

  Fly  1537 NERMLDRLMAESTLLVVFFYDDDCAECEEILEELEEIDGEADMFGIDFVKIASIQA------AKK 1595
            .|...|..:||. :..:.||...|..|:.:....||: .:.:..|:..||||.:..      ..|
Human   328 TENNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEEL-SKKEFPGLAGVKIAEVDCTAERNICSK 390

  Fly  1596 YEIVNIPSLVYFR 1608
            |.:...|:|:.||
Human   391 YSVRGYPTLLLFR 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259
		Thioredoxin_6	510..689	CDD:404691
		ER_PDI_fam	700..>916	CDD:273457
		PDI_a_family	1129..1226	CDD:239259
		TRX_family	1433..>1502	CDD:239245	18/81 (22%)
TXNDC5	NP_110437.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..63		11/22 (50%)
		PDI_a_ERp46	61..164	CDD:239303	22/112 (20%)
		ER_PDI_fam	66..432	CDD:273457	75/360 (21%)
		PDI_a_ERp46	190..290	CDD:239303	19/109 (17%)
		PDI_a_ERp46	323..424	CDD:239303	21/83 (25%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	429..432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810