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Protein Alignment hlk and Pdia5

DIOPT Version :10

Sequence 1:	NP_001163065.1	Gene:	hlk / 46017	FlyBaseID:	FBgn0010482	Length:	1786	Species:	Drosophila melanogaster
Sequence 2:	NP_082571.1	Gene:	Pdia5 / 72599	MGIID:	1919849	Length:	517	Species:	Mus musculus

Alignment Length:	522	Identity:	105/522 - (20%)
Similarity:	193/522 - (36%)	Gaps:	127/522 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 WLTDQTSSDQIEDITD-EMLDLIIEKMPHVAVLFYDKDQKKSQKILAELENIDDEC-DQNDIAFV 540
            ||:....|..||.|:| :.|..::....:|.|| |.:.:..::..|..|..:.... .|..:.:|
Mouse    18 WLSSTKVSSLIERISDPKDLKKLLRTRNNVLVL-YSESEVAAESHLKLLSTVAQAVKGQGTVCWV 81

  Fly   541 KIDD---DKEAKEWGIDEIP--------------------------SIVLF---ERGIPHIYEGD 573
            ...|   .|..|:..:|..|                          |||.|   .:| |.::|.|
Mouse    82 DCGDAESRKLCKKMKVDLSPKDKKIELFHYQDGAFHMQYDRAVTLKSIVAFLKDPKG-PPLWEED 145

  Fly   574 LMKEDELLGWLVHQKRYSEIPEVTDEMKD--KLVENTEH-LAVIFYDKDDKQDMRILNELENIDD 635
            ...:|     :||          .|..||  :|::..|. |.::||........||:...:....
Mouse   146 PGAKD-----VVH----------IDSEKDFRRLLKREEKPLLMMFYAPWCSMCKRIMPHFQKAAT 195

  Fly   636 ELEKEGIVIV--------RIDNAAEAKEYGLDHLPALIYFE-NKIPALYEGDLMNEDEVLEWLL- 690
            ::  .|.:::        ..:|..|  ||.:...|.:.||| .:....||......::::|||.
Mouse   196 QV--RGHIVLAGMNVYPSEFENIKE--EYNVRGYPTICYFEKGRFLFPYENYGSTAEDIVEWLKN 256

  Fly   691 ------------VQKKTATIEEVTDEILVTLINEHEYVVVFFTGPCEPGETCEHTL-------NA 736
                        ...:..::..:|||.....:.||..|:|.|..|     .|.|..       :|
Mouse   257 PLPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAP-----WCGHCKKMKPEFESA 316

  Fly   737 LESIDDELDEAGIIFV--TTEDTGIAKKYNVKTYPRLVFFRNRDPLHFTGDLDDEDEVLAWITDD 799
            .|.:..:.:.:|::..  .|.:..:|.::::..:|.|.:|:|.:. .....|..:.:.:.|:.:.
Mouse   317 AEVLHGDAESSGVLAAVDATVNEALAGRFHISAFPTLKYFKNGEQ-QAVPALRTKKKFIEWMQNP 380

  Fly   800 ETLEIPGKI-EEVNVKMLDKI-------LAENDHVVVFFYAEGDKKAQKILNELENIDDECEE-- 854
            |....|... ||....:|..:       |.:..|.:|.|||......:|::.......|..:|
Mouse   381 EAPPPPEPTWEEQQTSVLHLVGDNFRDTLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKEDR 445

  Fly   855 ----KDIDFVKTSDDDIDKEYDLPGLPALAFYRH-----KF-------------RTIYTGDLMKE 897
                ..:|.||..:.|:.::..:...|...:|.:     |:             ||:..|||.:.
Mouse   446 KIACAAVDCVKDKNQDLCQQEAVKAYPTFHYYHYGKLVEKYESDRTELGFTSFIRTLREGDLKRL 510

  Fly   898 EE 899
            |:
Mouse   511 EK 512

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.