Protein Alignment hlk and Dnajc10

DIOPT Version :10

• Sequence 1: NP_001163065.1
• Gene: hlk / 46017
• FlyBaseID: FBgn0010482
• Length: 1786
• Species: Drosophila melanogaster
• Sequence 2: NP_077143.2
• Gene: Dnajc10 / 66861
• MGIID: 1914111
• Length: 793
• Species: Mus musculus
• Alignment Length: 895
• Identity: 161/895 - (17%)
• Similarity: 307/895 - (34%)
• Gaps: 253/895 - (28%)

  Fly   858 DFVKTS-------DDDIDKEYDLPGLPAL-----------AFYRHKFRTIYTGDLMKEEEILEWV 904
            ||:|.:       |:|:.|:||..|...|           ::||:.| .||..|    .||:
Mouse    76 DFLKINRAYEVLKDEDLRKKYDKYGEKGLEDNQGGQYESWSYYRYDF-GIYDDD----PEII--- 132

  Fly   905 IDLHESTADVIESVDRKTLQVLINDVEHLAVFFYDDECESCSDILEELENIDDDTDKHGIQFVKS 969
                        :::|:.....:|..|...|.||...|..|.|:.........:.|  |:..:.:
Mouse   133 ------------TLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWREFAKEVD--GLLRIGA 183

  Fly   970 ----NDVKLAHEIGIFAFPALVYYETGV-PIMYDGNIASNQDVFNWILEQKADQSIQLINRDQLF 1029
                :|..|....|:.::|:|..:.:|: .:.|:|:              ::.:|:
Mouse   184 VNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYNGD--------------RSKESL--------- 225

  Fly  1030 EYIGTKDFLAVVFYKEDDPDSPRVLRHIELIDDEAAEYGIYIVKMHDKLMAKKYGFRNPPGLTYF 1094
                      |.|          .::|:.....|.:...  .|...:...|...|:.    :|:.
Mouse   226 ----------VAF----------AMQHVRSTVTELSTGN--FVNAIETAFAAGVGWL----ITFC 264

  Fly  1095 RKGKYINYDGDIDDEEEVLDWLTSPANMEMTDHIEQVNRKMFEKIRKNSDYVAVIFYSDECKQCP 1159
            .||:               |.|||...:.::..::.:         .|..:|........||...
Mouse   265 SKGE---------------DCLTSQTRLRLSGMLDGL---------VNVGWVDCDAQDSLCKSLD 305

  Fly  1160 RVLAEVEHID-----DEADKAGIDFV-KIDDKQMAKEYGVFALPAIVFFKPTSKEPVIYAGDLYE 1218
            ...:...:..     ::.:|:.:.|: .:|.|::..|. :..||..         .::.|..|.:
Mouse   306 TTASTTAYFPPGATLNDREKSSVLFLNSLDAKEIYMEI-IHNLPDF---------ELLSANQLED 360

  Fly  1219 EEQILTWLITQKDPSGDVIEDLEGERLVHLIEESGSIAVYFWNKTKCDICNS-------KAARKA 1276
            ......||:.......:...|.|.::|..|::........|...:...||:.       .|..|.
Mouse   361 RLAHHRWLVFFHFGKNENANDPELKKLKTLLKNEHIQVGRFDCSSAPGICSDLYVFQPCLAVFKG 425

  Fly  1277 RLKKERDQHQQEGGAASAAAAFGSEADPSEAAAGGAEDAPAAGSEGDSPP--ASAAAPADASTGK 1339
            :..||.:.|..: .......||..|:..|.....|.::.||:    |..|  ....||
Mouse   426 QGTKEYEIHHGK-KILYDILAFAKESVNSHVTTLGPQNFPAS----DKEPWLVDFFAP------- 478

  Fly  1340 QEDDADGCEQCTKVLEELENIDDDCDKHGITFVKTRDFSVADG----YGVHEYPALVYFEGGIPN 1400
                  .|..|..:|.||.......  :|...|.|.|.::.:|    |.:..||..|.|.....:
Mouse   479 ------WCPPCRALLPELRKASTLL--YGQLKVGTLDCTIHEGLCNMYNIQAYPTTVVFNQSSIH 535

  Fly  1401 VFEGELSEEEEVLQWLITQKTEDRIELITRQMLETMVEETQYLAVY---FYKINCNICD------ 1456
            .:||..| .|::|:::...:....:.| |......:|::.::..|:   ||...|:.|.
Mouse   536 EYEGHHS-AEQILEFIEDLRNPSVVSL-TPSTFNELVKQRKHDEVWMVDFYSPWCHPCQVLMPEW 598

  Fly  1457 ----QILEGLELIDD-ECDVFGIHMVKIQDPQLAKRYSIKTFPALVYFRNGNPLLFE-----GDL 1511
                :.|.||..:.. :|..:  |....|:       :::.:|.:.::...:...::     |..
Mouse   599 KRMARTLTGLINVGSVDCQQY--HSFCTQE-------NVQRYPEIRFYPQKSSKAYQYHSYNGWN 654

  Fly  1512 QNEQSVLEW---LIDDDNRELADEIEEVNERMLDRLMAESTLLVVFFYDDDCAECEEILEELE-- 1571
            ::..|:..|   .:...:.:|..  :..||::|.    ..|..||.||...|..|:....|.|
Mouse   655 RDAYSLRSWGLGFLPQASIDLTP--QTFNEKVLQ----GKTHWVVDFYAPWCGPCQNFAPEFELL 713

  Fly  1572 --EIDGEADMFGIDFVKIASIQAAKKYEIVNIPSLVYFRKQVPVLYDGDLHQHDKVITWLTSQDV 1634
              .|.|:.....:|..  |..|..:|..|...||:             .|:|:::     ..:.:
Mouse   714 ARMIKGKVRAGKVDCQ--AYPQTCQKAGIKAYPSV-------------KLYQYER-----AKKSI 758

  Fly  1635 FEIKNEIEEVNRKMLDKLLEENEFLAVFFYEHNQPDSTAALEKLENIDSE 1684
            :|     |::|.:       :.:.:|...|           .|||.:.|:
Mouse   759 WE-----EQINSR-------DAKTIAALIY-----------GKLETLQSQ 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hlk	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		ER_PDI_fam	381..>670	CDD:273457
		PDI_a_family	384..479	CDD:239259
		ER_PDI_fam	700..>916	CDD:273457	18/75 (24%)
		PDI_a_family	1129..1226	CDD:239259	13/102 (13%)
		TRX_family	1433..>1502	CDD:239245	13/82 (16%)
Dnajc10	NP_077143.2	DnaJ	35..157	CDD:440252	24/100 (24%)
		PDI_a_ERdj5_N	129..229	CDD:239301	24/159 (15%)
		ER_PDI_fam	130..551	CDD:273457	94/541 (17%)
		Trxb 1	235..350		22/145 (15%)
		Trxb 2	348..463		22/124 (18%)
		PDI_a_ERdj5_C	453..550	CDD:239302	28/116 (24%)
		PDI_a_ERdj5_C	556..663	CDD:239302	17/116 (15%)
		PDI_a_ERdj5_C	670..775	CDD:239302	28/142 (20%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	790..793