DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)01289 and qsox2

DIOPT Version :9

Sequence 1:	NP_001163065.1	Gene:	l(2)01289 / 46017	FlyBaseID:	FBgn0010482	Length:	1786	Species:	Drosophila melanogaster
Sequence 2:	XP_009300239.1	Gene:	qsox2 / 559603	ZFINID:	ZDB-GENE-110203-4	Length:	656	Species:	Danio rerio

Alignment Length:	675	Identity:	122/675 - (18%)
Similarity:	204/675 - (30%)	Gaps:	250/675 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   879 LAFYRHKFRTIYTGDLMKEEEILEWVIDLHESTADVIESVDRKTLQVLINDVEHLAVFFYDDECE 943
            |.|.|.:...:||     ||:.:            ||.|.| ...|.::|......|.||...|.
Zfish    15 LLFGRAQPARLYT-----EEDPV------------VILSSD-SLKQTVLNSSSAWLVQFYSSWCG 61

  Fly   944 SCSDILEELENIDDDTDKHGIQFVKSNDVKLAH--------EIGIFAFPALVYYETGVPIMYDGN 1000
            .|.......:.:..|. |...|.::...|..||        |.||..:|...|::.
Zfish    62 HCIQYSPTWKALAGDV-KDWAQAIRIGVVDCAHEKNFDICKEFGIHFYPTFRYFKA--------- 116

  Fly  1001 IASNQDVFNWI--LEQKADQSIQLINR--------------------------DQLFEYIG--TK 1035
                .|..|..  ..|.||:.:|.:.:                          :.:...:|  |:
Zfish   117 ----HDTTNDFGKTYQGADRELQTVRQLMVNFIQNHTRQDWPVGCPPLHPARSEDVLSLMGKKTE 177

  Fly  1036 DFLAVVFYKEDDPDSPRVLRHI--ELIDDEAAEYGIYIVK--MHDKLMAKKYGFRNPPGLTYFRK 1096
            .:.||:.   :|.:|     :|  |:|.|.....|:.:.:  ..|:|:..|.|..:.|....|:.
Zfish   178 HYTAVIV---EDGNS-----YIGREVILDLMPYEGLVVKRALSSDQLLMDKLGISSVPSAYLFQP 234

  Fly  1097 GKYINYDGDIDDEEEVLDWLTS------PA--NMEMTDHIE-----------QVNRKMFEKIRKN 1142
                |....:.:.::.|.:..|      |.  ..:.|..::           ||..|.|:|.:
Zfish   235 ----NGTHTVLNVQKKLRFFFSSFLKLLPGVHRKQSTSSLQRPQPGINGQGAQVEWKEFKKSK-- 293

  Fly  1143 SDYVAVIFYSDECKQCPRVLAEVE---H--IDDEADKAGIDFVKIDDKQMAKEYGVFALPAIVFF 1202
                   .|..:.:.....|..||   |  ::.|..|...|||.:..|.......|..|
Zfish   294 -------VYMADLESGLHYLLRVELATHKTLEGEELKTFKDFVTVVAKLFPGHQSVVKL------ 345

  Fly  1203 KPTSKEPVIYAGDLYEEEQILTWLIT---QKDPSGDVIEDLEGERL----VHLIE-------ESG 1253
                            .|.:|.||::   :|.|. |.|.||...::    ::|.|       :..
Zfish   346 ----------------LETLLEWLVSLPLEKIPY-DAILDLVNNKMRISGLYLSEQVQWVGCQGS 393

  Fly  1254 SIAV-----YFWNKTKCDICNSKAARKARLKKERDQHQQEGGAASAAAAFGSEADPSEAAAGGAE 1313
            |:|:     ..|  |...:...:||.:                            |...|..|.|
Zfish   394 SVALRGYPCSLW--TLFHVLTVQAANR----------------------------PDALANTGFE 428

  Fly  1314 DAPAAGSEGDSPPASAAAPADASTGKQEDDADGCEQCTKVLEELENIDDDCDKHGITFVKTRDFS 1378
            |.|.|..:              :..:......||::|.|..||:.       :..:..|||.|
Zfish   429 DDPLAVLQ--------------TMRRYIGTFFGCQECGKHFEEMA-------QESLNQVKTVD-- 470

  Fly  1379 VADGYGVHEYPALVYFEGGIPNVFEGELSEEEEVLQWLITQKTEDRIELITRQMLETMVEETQYL 1443
                                            |.:.||..:..:....|......:.|..:||:.
Zfish   471 --------------------------------EAVLWLWRKHNQVNARLSGSMSEDPMFPKTQWP 503

  Fly  1444 AVYFYKINCNICDQILEGLELIDDE 1468
            ....    |..|.:..|||.:.:::
Zfish   504 TPDL----CPTCHEEQEGLHVWNEQ 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259
		Thioredoxin_6	510..689	CDD:404691
		ER_PDI_fam	700..>916	CDD:273457	8/36 (22%)
		PDI_a_family	1129..1226	CDD:239259	20/112 (18%)
		TRX_family	1433..>1502	CDD:239245	8/36 (22%)
qsox2	XP_009300239.1	PDI_a_QSOX	30..141	CDD:239290	28/137 (20%)
qsox2	XP_009300239.1	Evr1_Alr	403..499	CDD:282612	26/180 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900