Protein Alignment hlk and dnajc10

DIOPT Version :10

• Sequence 1: NP_001163065.1
• Gene: hlk / 46017
• FlyBaseID: FBgn0010482
• Length: 1786
• Species: Drosophila melanogaster
• Sequence 2: NP_001077016.1
• Gene: dnajc10 / 557858
• ZFINID: ZDB-GENE-070327-1
• Length: 791
• Species: Danio rerio
• Alignment Length: 801
• Identity: 151/801 - (18%)
• Similarity: 270/801 - (33%)
• Gaps: 240/801 - (29%)

  Fly   980 IFAFPALVYYETGVPIMYDGNIASNQDVFNWI-LEQKADQSIQLINRD--QLFEYIGTKDFLAVV 1041
            :|||.|:..:.         :|:|::|.:..: :.::|.      .||  |.|:.      ||:.
Zfish    16 LFAFIAVWLFV---------SISSDEDYYKLLGISREAS------TRDIRQAFKK------LALT 59

  Fly  1042 FYKEDDPDSP-------RVLRHIELIDDEAAEYGIYIVKMHDKLMAKKYGFRNPPGLTYFRKG-- 1097
            .:.:.:|:..       ::.|..|::.||.              :.|||......||...::|
Zfish    60 MHPDKNPNDETAHDKFLKINRAYEVLKDED--------------LRKKYDKYGEKGLQDEQQGGR 110

  Fly  1098 ----KYINYD-GDIDDEEEVLDWLTSPANMEMTDHIEQVNRKMFEKIRKNSDYVAVIFYSDECKQ 1157
                .|..|| |..||:.|                |..::|..|:....:.:...|.||...|..
Zfish   111 YESWNYYRYDFGIYDDDPE----------------ITTLDRGDFDAAVNSGEVWFVNFYFPRCSH 159

  Fly  1158 CPRVLAEVEHIDDEADKAGIDFVKI------DDKQMAKEYGVFALPAIVFFKP------------ 1204
            |..:.........|.|  |:  ::|      |:..:.:..|:.:.|::..|:.
Zfish   160 CHDLAPTWREFAKEMD--GV--IRIGAVNCGDNGMLCRSKGINSYPSLYVFRAGMNPEKYFNDRT 220

  Fly  1205 ------------TSKEPVIYAGDLYEE-----EQILTWLITQKDPSGDVIEDLEGERLVHLIEES 1252
                        .||...::.|::|.|     .:.:.||||....:||.:|.....:|..:::
Zfish   221 KSSLTKFAMQFVKSKVTELWQGNIYSEIERAFAERIGWLITFCADTGDCLESQTRRKLAGMLD-- 283

  Fly  1253 GSIAVYFWNKTK-CDICNSKAARKARLKKERDQHQQEGGAASAAAAFGSEADPSEAAAGGAEDAP 1316
            |.:.|.:.:.|| .|:|.|....                 .|..|.|
Zfish   284 GLVNVGWMDCTKQADLCESFEIN-----------------TSTTALF------------------ 313

  Fly  1317 AAGSEGDSPPASAAAPADASTGKQE-DDADGCEQCTKVLEELENIDDDCDKHGITFVKTRDFSVA 1380
                    ||.|:.....:....|. |..:...|..:.|.:||.:.....:|.:...:   :.|:
Zfish   314 --------PPGSSLTQKGSVLFIQSLDTKEIYAQVLQHLPDLEILTKSSFEHKLAHHR---WLVS 367

  Fly  1381 DGYG-----VHEYPAL-------------------------VYFEGGIPNVFEG------ELSEE 1409
            ..:|     .|||..|                         :|.......||:|      |:...
Zfish   368 FSFGRNDLASHEYKKLNALLKNSHIQVGKVDCISDSELCSSLYIHKPCVAVFKGVGIHDFEIHHG 432

  Fly  1410 EEVLQWLITQKTEDRIELITRQMLETMV-EETQYLAVYFYKINCNICDQILEGLELIDDECDVFG 1473
            ::.|..::....|.....:|....|... .|.:...|.|:...|..|..:|.  ||......:||
Zfish   433 KDALYNVVAFAKESVNAHVTTLRPENFPNHEKEPWLVDFFAPWCPPCRALLP--ELRKASIQLFG 495

  Fly  1474 ----------IHMVKIQDPQLAKRYSIKTFPALVYFRNGNPLLFEGDLQNEQSVLEWLIDDDNRE 1528
                      ||      ..|...|:|..:|..|.|...:...:||. .:...:||::.|..|..
Zfish   496 QLKFGTLDCTIH------EGLCNTYNIHAYPTTVIFNKSSIHEYEGH-HSADGILEFIEDLVNPV 553

  Fly  1529 LADEIEEVNERMLDRLMAESTLLVVFFYDDDCAECEEILEELEEIDGEADMF-GIDFVKIASIQA 1592
            :.....|..:.::.|..:..|.: |.||...|..|:.:|.|...:   |.|. ||  |.:.::..
Zfish   554 VVTLGPESFQELVKRRKSSETWM-VDFYAPWCGPCQALLPEWRRM---ARMLSGI--VNVGTVDC 612

  Fly  1593 AKKYEIVNIPSLVYFRKQVPV--LYDGDLHQHDKVIT---WLTSQDVFEIKN-EIEEVNRKMLD- 1650
            .|.:......|:    :..|.  |:..:.::.|:..|   |  .:|.|.:|. .:..:.|..:|
Zfish   613 QKHHSFCQSESV----RAYPEIRLFPQNSNRRDQYQTYNGW--HRDAFSLKAWALSSLPRASVDL 671

  Fly  1651 -------KLLEENEFLAVFFY 1664
                   |:|...:...:.||
Zfish   672 SPEDFKRKVLGGKDHWVLDFY 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hlk	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		ER_PDI_fam	381..>670	CDD:273457
		PDI_a_family	384..479	CDD:239259
		ER_PDI_fam	700..>916	CDD:273457
		PDI_a_family	1129..1226	CDD:239259	20/131 (15%)
		TRX_family	1433..>1502	CDD:239245	19/79 (24%)
dnajc10	NP_001077016.1	DnaJ	33..>120	CDD:440252	20/112 (18%)
		PDI_a_ERdj5_N	128..228	CDD:239301	17/119 (14%)
		Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold	<276..318	CDD:469754	13/86 (15%)
		PDI_a_family	348..443	CDD:239259	14/97 (14%)
		PDI_a_ERdj5_C	450..546	CDD:239302	24/104 (23%)
		PDI_a_ERdj5_C	552..660	CDD:239302	25/119 (21%)
		PDI_a_ERdj5_C	666..772	CDD:239302	6/27 (22%)