DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)01289 and txndc16

DIOPT Version :9

Sequence 1:	NP_001163065.1	Gene:	l(2)01289 / 46017	FlyBaseID:	FBgn0010482	Length:	1786	Species:	Drosophila melanogaster
Sequence 2:	XP_685017.4	Gene:	txndc16 / 556973	ZFINID:	ZDB-GENE-100712-1	Length:	804	Species:	Danio rerio

Alignment Length:	1011	Identity:	197/1011 - (19%)
Similarity:	356/1011 - (35%)	Gaps:	319/1011 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 CDALGITFVKIDNPEEAV-----EYGINKVPKL-------IYFEKGI-PTIYEGNLEDEEKLLKW 478
            |....:|||.|...|:..     :.|.|.:.::       |||...: |||        |..::.
Zfish     2 CTVYLVTFVFILTAEQCFSKLMEDSGQNLMERMQTGKTSFIYFGNHVNPTI--------ELFIEQ 58

  Fly   479 LTDQTSSDQIEDI----------TDEMLDLII-EKMPHVAVLFYDKDQKKSQKILAELENIDDEC 532
            |  |.|:|.:||.          .|::..... ||:...|.||      :..::|...: ||...
Zfish    59 L--QMSADALEDYGIAVVMVNCSKDDIAKYCTGEKLLTKAYLF------RGSEVLRSFD-IDTVF 114

  Fly   533 DQNDIAFVKIDDDKEAKEWGIDEIPSIVLFERGIPHIYEGDLMKEDELLGWLVHQKRYSEI---- 593
            |.|.|               :..:...|||.. :.:::     ...||||.....|:.|:|
Zfish   115 DVNAI---------------VSHVLFSVLFNE-VLYVH-----TPAELLGVESAAKQNSDIVVGH 158

  Fly   594 ------PEVTDEMKDKLVENTEHLAVIFYDKDDKQDMRILNELENIDDELEKEGIVIVRIDNAAE 652
                  ||....|:...|..|::           |.::....|     .|::.|:|   ..::::
Zfish   159 IPVLGLPEHRALMETAFVYGTKY-----------QFVQTTGSL-----VLKRMGVV---NPSSSQ 204

  Fly   653 AKEYGLDHLPALIYFENKIPALYEGDLMNEDEVLEWLLVQKKTATIEEVTDEILVTLINEHEYVV 717
            |:.:.| |..::....:..|:......:|...:..:|.:.:.....|.|||...|.:::.|..|.
Zfish   205 ARLWFL-HCKSVSLQSDPCPSTAMSKPINTINIHTFLQLMEAPLVTEAVTDPSEVDVVHIHLSVP 268

  Fly   718 V--FFTGPCEPGETCEHTLNALESIDDEL-DEAGIIFVTTEDTGIAKKYNVKTYPRLVFFRNRDP 779
            |  .|:.|    :|.....:..:::..:| .|.|::.:..::.      .|||           |
Zfish   269 VLYLFSQP----QTQHLDRDTAQTVALQLRGEVGVVLIHRDNP------KVKT-----------P 312

  Fly   780 LHFTGDLDDEDEVLAWITDDETLEIPGKIEEVNVKMLDKILAENDHVVVFFYAEGDKKAQKILNE 844
            |.:........|.:.:.    ||..|   ||| ||:..:.|.:.|.                 .|
Zfish   313 LKYNAAYRLPQEDVKYF----TLSAP---EEV-VKLFKETLLQKDK-----------------TE 352

  Fly   845 LENIDDECEEKDIDFVKTSDDDIDKEYDLPGLPALAFYRHKFRTIYTGDLMKEEEILEWVIDLHE 909
            .|..||| ...|:|.:   ||::.:          :.||.:       |||.:   ||.|.:|
Zfish   353 DEEEDDE-HWSDLDIL---DDEVSE----------SVYRDR-------DLMLD---LEPVTEL-- 391

  Fly   910 STADVIESVDRKTLQVLINDVEHLAVFFY---DDEC----ESCSDILEELENIDDDTDKHGIQFV 967
             |||        |.|..|...|...|.||   |..|    :|..::.|.:|::
Zfish   392 -TAD--------TFQTAIKQNEITVVLFYFKWDAVCMAFIQSYVEVAEAVEDV------------ 435

  Fly   968 KSNDVKLA-----------HEIGIFAFPALVYY--ETGVPIMYDGNIASNQDVFNWILEQKADQS 1019
              |.|:||           .:..|.:||.::.|  :......|.| :...:.:..:||.......
Zfish   436 --NGVELAAVDCGEWTDICRDQNITSFPTVLIYCPKAAAAQPYRG-MMGTKSLQRFILLSLVSTP 497

  Fly  1020 IQLINRDQLFEYIGTKDFLAVVFYKEDDPDSP-RVLRHIELIDD-------EAAEY--GIYIVKM 1074
            :.|.:..::..::....:...|:.      :| |||.....:.|       |||..  |..|:
Zfish   498 VHLSSSAEVMSFLEGDLYRKYVYL------TPVRVLGLFSSMQDMGVSSFEEAARLLRGETII-- 554

  Fly  1075 HDKLMAKKYGFRNPPGLTYFRKGKYINYDGDIDDEEEVLDWLTSPANMEMTDHIEQVNRKMFEK- 1138
              .|.|.|...:...||:.......:::...:..:.     .:.|::: .|||::.:.|...|:
Zfish   555 --GLFAHKEAAKWVEGLSVNLPALLVSHGPALPHQV-----FSLPSSL-ATDHVKLIQRVELERF 611

  Fly  1139 -----------IRKNSDYVAVIFYSDECKQCPRVLAEVEHIDDEADKAGIDF----------VKI 1182
                       :......:.:....:|..:..|.|||:..:   .....:||          ..:
Zfish   612 PELTVENLPWYLELEKPLLLLFIGKEESTESTRSLAEINQL---LGSGQLDFFLPCWIHLGRTPV 673

  Fly  1183 DDKQMAKEYG-VFALPAIVFFK-PTSKEPVIYAGDL-YEEEQILTWLITQKD----PSGDVIEDL 1240
            ....:.|..| |..||::|..: .|..|..::..:. .:.|.||.|:...:|    |:| :|.|:
Zfish   674 GRSILEKYLGFVPPLPSLVISQIKTGGEVFLFPSERPLKAENILRWIHDVEDRHEQPAG-LIPDV 737

  Fly  1241 EG-------ERLVHLIEESGSIAVYFWNKTKCDICNSKAARKARLKKE--RDQHQQEGGAASAAA 1296
            :.       :.|..:.:|:.:.                ||:||...|.  |:.|:::
Zfish   738 KWGPPVPFFDFLAIMDQEAPTY----------------AAQKAPKTKNGGRENHKEQ-------- 778

  Fly  1297 AFGSEADPSEAAAGGAEDAPAAGSEGDSPPASAAAP 1332
               :...|::             |:|..|.|:..||
Zfish   779 ---NHVTPNQ-------------SQGPHPSANPQAP 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259	15/64 (23%)
		Thioredoxin_6	510..689	CDD:404691	32/188 (17%)
		ER_PDI_fam	700..>916	CDD:273457	50/218 (23%)
		PDI_a_family	1129..1226	CDD:239259	20/121 (17%)
		TRX_family	1433..>1502	CDD:239245
txndc16	XP_685017.4	PDI_a_family	389..489	CDD:239259	26/125 (21%)
txndc16	XP_685017.4	Thioredoxin_6	530..722	CDD:290560	36/204 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900