DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)01289 and pdia5

DIOPT Version :9

Sequence 1:NP_001163065.1 Gene:l(2)01289 / 46017 FlyBaseID:FBgn0010482 Length:1786 Species:Drosophila melanogaster
Sequence 2:NP_001107048.1 Gene:pdia5 / 556162 ZFINID:ZDB-GENE-030521-5 Length:528 Species:Danio rerio


Alignment Length:493 Identity:85/493 - (17%)
Similarity:174/493 - (35%) Gaps:124/493 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   800 ETLEIPGKIEEVN-VKMLDKILAENDHVVVFFYAE-----------------------------G 834
            :.:::...||:|| .|...|:|....:|:|.:...                             |
Zfish    30 QAVKVSPLIEKVNDHKDFKKLLRTRTNVLVLYTKSASSGDAHLKLLSDVAQAVKGQGTIAWVNCG 94

  Fly   835 DKKAQKILNELENIDDECEEKDIDFVKTSDDDIDKEYDLPGL--PALAFYRHKFRTIYTGDLMKE 897
            |.:.:|:..::: :|...:.|.::.:...|.....||:.|..  ..:||.:..     .|..:.|
Zfish    95 DSEGRKLCKKVK-VDPSSKTKGVELLHYKDGTFHTEYNRPATFKSMVAFLKDP-----AGAPLWE 153

  Fly   898 EEILEWVIDLHESTADVIESVDRKTLQVLINDVEH-LAVFFYDDECESCSDILEELENIDDDT-- 959
            |         :....||:.....|..:.|:...|. :.:.||...|..|..:....:....:|  
Zfish   154 E---------NPEAKDVVHIESEKDFRKLLKREERPILMMFYAPWCGVCKRMQPIFQQAATETKG 209

  Fly   960 -------DKHGIQFVKSNDVKLAHEIGIFAFPALVYYETGVPI-MYDGNIASNQDVFNWILEQKA 1016
                   :.|..:|   :.||  .|..:..:|...|:|.|..: .|:...|:::|:.:|:...:.
Zfish   210 KYVLAGMNVHPAEF---DGVK--QEFSVKGYPTFCYFEKGKFLHHYENYGATSKDITDWLKNPQP 269

  Fly  1017 DQ-------------SIQLINRDQLFEYIGTKDFLAVVFYK--------------------EDDP 1048
            .|             ::..:..|....::.......::||.                    ..||
Zfish   270 PQPKTPEVPWSESGSAVFHLTDDSFDSFLEEHPSALIMFYAPWCGHCKKMKPEYDDAAETLNKDP 334

  Fly  1049 DSPRVLRHIELIDDEAAEYGIYIVKMHDKLMAKKYGFRNPPGLTYFRKGKYINYDGDIDDEEEVL 1113
            :||.||..::             ..:| |...:::.....|.:.||.||:.......:..:::::
Zfish   335 NSPGVLAAVD-------------TTIH-KSTGERFKISGFPTVKYFEKGEEKYTLPHLRSKDKII 385

  Fly  1114 DWLTSPANM--------EMTDHIEQVNRKMFEKIRKNSDYVAVIFYSDECKQCPRVL------AE 1164
            :||.:|...        ||...:..:..:.|.:..|...:..|:||:..|..|...:      ||
Zfish   386 EWLKNPQAPPPPEKSWDEMPSSVSHLGAEDFRESLKKKKHALVMFYAPWCPHCKNAVPHFTTAAE 450

  Fly  1165 VEHIDDEADKAGIDFVKIDDKQMAKEYGVFALPAIVFF 1202
            :...|.:...|.:|..|..:.::.|:.||...|...::
Zfish   451 MFKEDRKIAYAAVDCTKGQNHELCKQEGVEGYPTFNYY 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)01289NP_001163065.1 PDI_a_family 50..145 CDD:239259
PDI_a_family 384..479 CDD:239259
Thioredoxin_6 510..689 CDD:404691
ER_PDI_fam 700..>916 CDD:273457 25/147 (17%)
PDI_a_family 1129..1226 CDD:239259 17/80 (21%)
TRX_family 1433..>1502 CDD:239245
pdia5NP_001107048.1 PDI_b_PDIR_N 36..147 CDD:239365 20/116 (17%)
PDI_a_PDIR 160..264 CDD:239295 22/108 (20%)
ER_PDI_fam 181..512 CDD:273457 57/327 (17%)
PDI_a_PDIR 285..388 CDD:239295 16/116 (14%)
PDI_a_PDIR 407..510 CDD:239295 17/82 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0191
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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