DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)01289 and TMX3

DIOPT Version :9

Sequence 1:	NP_001163065.1	Gene:	l(2)01289 / 46017	FlyBaseID:	FBgn0010482	Length:	1786	Species:	Drosophila melanogaster
Sequence 2:	NP_061895.3	Gene:	TMX3 / 54495	HGNCID:	24718	Length:	454	Species:	Homo sapiens

Alignment Length:	389	Identity:	79/389 - (20%)
Similarity:	143/389 - (36%)	Gaps:	122/389 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   548 AKEWGIDEIPSIVLFERGIPHIYEGDLMKED------ELLGWLVH-----------QKRY----- 590
            |.|:|:...|:|.|.:..:.:.|.|...|:|      .:.|.|:.           |||:
Human    91 ASEFGVRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFEHMQKRHRVFFV 155

  Fly   591 ---SEIPEVTDEMKDKLVENTEHLAVIFYDKDDKQDMRILNELENIDDELEKEGIVIVRIDNAAE 652
               .|.|     :|:|.::....|.|..|             ..:..:|:..|.:.
Human   156 YVGGESP-----LKEKYIDAASELIVYTY-------------FFSASEEVVPEYVT--------- 193

  Fly   653 AKEYGLDHLPALIYFENKIPALY----EGDL---MNEDEVLEWLLVQKKTATIEEVTDE---ILV 707
                 |..:||::.|:::...:|    :|||   :|.:....:|.:.  ...:.|:.|.   :.:
Human   194 -----LKEMPAVLVFKDETYFVYDEYEDGDLSSWINRERFQNYLAMD--GFLLYELGDTGKLVAL 251

  Fly   708 TLINEHEYVVVFFTGPCEPGETCEHTLNALESIDDELDEAGIIFVTTEDTGIAKKYNVKTYPRLV 772
            .:|:|....|             |||  .|:||..|               :|:.|      |.:
Human   252 AVIDEKNTSV-------------EHT--RLKSIIQE---------------VARDY------RDL 280

  Fly   773 FFRNRDPLHFTGDLDDEDEVLAWITDDETLEIPGKIEEVNVK--MLDKILAENDHVVVFF--YAE 833
            |.|:   ..| |.:|..|.:...:.|:.|:.....:...|.:  :||:.:...:.:|.|.  ..:
Human   281 FHRD---FQF-GHMDGNDYINTLLMDELTVPTVVVLNTSNQQYFLLDRQIKNVEDMVQFINNILD 341

  Fly   834 GDKKAQ---KILNELENIDDECEEKDIDFVKTSDDDIDKEYDLP-GLPALAFYRHKFRTIYTGD 893
            |..:||   .||..|:.|..:.:...:...|:|.......:.|| |:.::..|     .|||.|
Human   342 GTVEAQGGDSILQRLKRIVFDAKSTIVSIFKSSPLMGCFLFGLPLGVISIMCY-----GIYTAD 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259
		Thioredoxin_6	510..689	CDD:404691	33/172 (19%)
		ER_PDI_fam	700..>916	CDD:273457	45/205 (22%)
		PDI_a_family	1129..1226	CDD:239259
		TRX_family	1433..>1502	CDD:239245
TMX3	NP_061895.3	PDI_a_TMX3	27..130	CDD:239298	10/38 (26%)
		ER_PDI_fam	29..>346	CDD:273457	63/328 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..454
		Di-lysine motif	451..454
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910