Protein Alignment hlk and DNAJC10

DIOPT Version :10

• Sequence 1: NP_001163065.1
• Gene: hlk / 46017
• FlyBaseID: FBgn0010482
• Length: 1786
• Species: Drosophila melanogaster
• Sequence 2: NP_061854.1
• Gene: DNAJC10 / 54431
• HGNCID: 24637
• Length: 793
• Species: Homo sapiens
• Alignment Length: 843
• Identity: 160/843 - (18%)
• Similarity: 276/843 - (32%)
• Gaps: 290/843 - (34%)

  Fly  1001 IASNQDVFNWILEQKADQSIQLINRDQLFEYIGTKDFLAVVFYKEDDPDSP-------RVLRHIE 1058
            :.::||.::.:...|...|.::   .|.|:.      ||:..:.:.:|::|       ::.|..|
Human    30 VGTDQDFYSLLGVSKTASSREI---RQAFKK------LALKLHPDKNPNNPNAHGDFLKINRAYE 85

  Fly  1059 LIDDEAAEYGIYIVKMHDKLMAKKYGFRNPPGLTYFRKGKYINYD-GDIDDEEEVLDWLTSPANM 1122
            ::.||.      :.|.:||...|  |..:..|..| ....|..|| |..||:.|::
Human    86 VLKDED------LRKKYDKYGEK--GLEDNQGGQY-ESWNYYRYDFGIYDDDPEII--------- 132

  Fly  1123 EMTDHIEQVNRKMFEKIRKNSDYVAVIFYSDECKQCPRVLAEVEHIDDEADKAGIDFVKI----- 1182
                   .:.|:.|:....:.:...|.|||..|..|..:.........|.|    ..::|
Human   133 -------TLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVD----GLLRIGAVNC 186

  Fly  1183 -DDKQMAKEYGVFALPAIVFFKPTSKEPVIYAGDLYEEEQI------------------------ 1222
             ||:.:.:..||.:.|::..|: :...||.|.||..:|..:
Human   187 GDDRMLCRMKGVNSYPSLFIFR-SGMAPVKYHGDRSKESLVSFAMQHVRSTVTELWTGNFVNSIQ 250

  Fly  1223 ------LTWLITQKDPSGDVIED---------LEG------------ERLVHLIEESGSIAVYF- 1259
                  :.||||.....||.:..         |:|            :.|...::.:.|...||
Human   251 TAFAAGIGWLITFCSKGGDCLTSQTRLRLSGMLDGLVNVGWMDCATQDNLCKSLDITTSTTAYFP 315

  Fly  1260 -----WNKTKCDI--CNSKAARKARL---------------------------------KKE--- 1281
                 .||.|..|  .||..|::..|                                 |.|
Human   316 PGATLNNKEKNSILFLNSLDAKEIYLEVIHNLPDFELLSANTLEDRLAHHRWLLFFHFGKNENSN 380

  Fly  1282 -----------RDQHQQEGGAASAAA--------------------------------------A 1297
                       ::.|.|.|....::|                                      |
Human   381 DPELKKLKTLLKNDHIQVGRFDCSSAPDICSNLYVFQPSLAVFKGQGTKEYEIHHGKKILYDILA 445

  Fly  1298 FGSEADPSEAAAGGAEDAPAAGSEGDSPP--ASAAAPADASTGKQEDDADGCEQCTKVLEELENI 1360
            |..|:..|.....|.::.||    .|..|  ....||             .|..|..:|.||...
Human   446 FAKESVNSHVTTLGPQNFPA----NDKEPWLVDFFAP-------------WCPPCRALLPELRRA 493

  Fly  1361 DDDCDKHGITFVKTRDFSVADG----YGVHEYPALVYFEGGIPNVFEGELSEEEEVLQWL----- 1416
            .:..  :|.....|.|.:|.:|    |.:..||..|.|.....:.:||..| .|::|:::
Human   494 SNLL--YGQLKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQSNIHEYEGHHS-AEQILEFIEDLMN 555

  Fly  1417 -----ITQKTEDRIELITRQMLETMVEETQYLAVYFYKINCNICD----------QILEGLELID 1466
                 :|..|.:  ||:|::      :..:...|.||...|:.|.          :.|.||..:.
Human   556 PSVVSLTPTTFN--ELVTQR------KHNEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVG 612

  Fly  1467 D-ECDVFGIHMVKIQDPQLAKRY-SIKTFP-----ALVYFRNGNPLLFEGDLQNEQSVLEWLIDD 1524
            . :|..:  |....|:.  .:|| .|:.||     |..|..      :.|..::..|:..|.:
Human   613 SIDCQQY--HSFCAQEN--VQRYPEIRFFPPKSNKAYHYHS------YNGWNRDAYSLRIWGL-- 665

  Fly  1525 DNRELADEIEEVNERMLDRLMAESTL-----LVVFFYDDDCAECEEILEELE----EIDGEADMF 1580
                  ..:.:|:..:..:..:|..|     .|:.||...|..|:....|.|    .|.|:....
Human   666 ------GFLPQVSTDLTPQTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARMIKGKVKAG 724

  Fly  1581 GIDFVKIASIQAAKKYEIVNIPSL-VYFRKQVPVLY-DGDLHQHD-KVITWLTSQDVFEIKNE 1640
            .:|....|  |..:|..|...|:: .||.::....: :..::..| |.|..|.|:.:..::|:
Human   725 KVDCQAYA--QTCQKAGIRAYPTVKFYFYERAKRNFQEEQINTRDAKAIAALISEKLETLRNQ 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hlk	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		ER_PDI_fam	381..>670	CDD:273457
		PDI_a_family	384..479	CDD:239259
		ER_PDI_fam	700..>916	CDD:273457
		PDI_a_family	1129..1226	CDD:239259	23/132 (17%)
		TRX_family	1433..>1502	CDD:239245	18/85 (21%)
DNAJC10	NP_061854.1	DnaJ	35..157	CDD:440252	33/155 (21%)
		PDI_a_ERdj5_N	129..229	CDD:239301	24/120 (20%)
		Trxb 1	235..350		20/114 (18%)
		Trxb 2	348..463		11/114 (10%)
		PDI_a_ERdj5_C	453..550	CDD:239302	28/116 (24%)
		PDI_a_ERdj5_C	556..663	CDD:239302	25/124 (20%)
		PDI_a_ERdj5_C	670..775	CDD:239302	23/106 (22%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	790..793