Protein Alignment l(2)01289 and P4HB

DIOPT Version :9

• Sequence 1: NP_001163065.1
• Gene: l(2)01289 / 46017
• FlyBaseID: FBgn0010482
• Length: 1786
• Species: Drosophila melanogaster
• Sequence 2: XP_024306545.1
• Gene: P4HB / 5034
• HGNCID: 8548
• Length: 546
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 122/520 - (23%)
• Similarity: 192/520 - (36%)
• Gaps: 164/520 - (31%)

  Fly   671 IPALYEGDLMNEDEVLEWLLVQKKTATIEEVTDEILVTLINEHEYVVVFFTGPCEPGETCEHT-- 733
            :.||...|...|:   :.:||.:|:...|.:.         .|:|::|.|..|     .|.|.
Human    11 VAALVRADAPEEE---DHVLVLRKSNFAEALA---------AHKYLLVEFYAP-----WCGHCKA 58

  Fly   734 -----LNALESIDDELDEAGIIFV-TTEDTGIAKKYNVKTYPRLVFFRNRD---PLHFTGDLDDE 789
                 ..|...:..|..|..:..| .||::.:|::|.|:.||.:.||||.|   |..:|.. .:.
Human    59 LAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAG-REA 122

  Fly   790 DEVLAWI---TDDETLEIP-GKIEEVNVKMLDKILAENDHVVV--FFYAEGDKKAQKILNELENI 848
            |:::.|:   |......:| |...|        .|.|:..|.|  ||.......|::.|...|.|
Human   123 DDIVNWLKKRTGPAATTLPDGAAAE--------SLVESSEVAVIGFFKDVESDSAKQFLQAAEAI 179

  Fly   849 DDECEEKDIDFVKTSDDDIDKEYDLPGLPALAFYRHKF---RTIYTGDLMKEEEI-------LEW 903
            |      ||.|..||:.|:..:|.|.....:.|  .||   |..:.|::.||..:       |..
Human   180 D------DIPFGITSNSDVFSKYQLDKDGVVLF--KKFDEGRNNFEGEVTKENLLDFIKHNQLPL 236

  Fly   904 VIDLHESTADVIESVDRKTLQVLINDVEHLAVFFYDDECESCSDILEELENIDDDTDKHGIQFVK 968
            ||:..|.||..|...:.||         |:.:|.    .:|.||...:|.|.
Human   237 VIEFTEQTAPKIFGGEIKT---------HILLFL----PKSVSDYDGKLSNF------------- 275

  Fly   969 SNDVKLAHEIGIFAFPALVYYETGVPIMYDGNIASNQDVFNWILEQKADQSIQLINRDQLFEYIG 1033
                |.|.|    :|...:.:     |..|.:...||                     ::.|:.|
Human   276 ----KTAAE----SFKGKILF-----IFIDSDHTDNQ---------------------RILEFFG 306

  Fly  1034 TKDFLAVVFYKEDDPDSPRVLRHIELIDDEAAEYGIYIVKMHDKLMAKKYGFRNPPGLT----YF 1094
            .|        ||:.|    .:|.|.| ::|..:|    ....::|.|::        :|    .|
Human   307 LK--------KEECP----AVRLITL-EEEMTKY----KPESEELTAER--------ITEFCHRF 346

  Fly  1095 RKGKYINYDGDIDDEEEVLDWLTSPANMEMTDHIEQVNRKMFEKIRKNSDYVAVIFYSDECKQCP 1159
            .:||...:   :..:|...||...|..:.:..:.|.|   .|:: :||   |.|.|    ||.||
Human   347 LEGKIKPH---LMSQELPEDWDKQPVKVLVGKNFEDV---AFDE-KKN---VFVEF----CKCCP 397

  Fly  1160  1159
            Human   398  397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259
		Thioredoxin_6	510..689	CDD:404691	4/17 (24%)
		ER_PDI_fam	700..>916	CDD:273457	63/242 (26%)
		PDI_a_family	1129..1226	CDD:239259	12/31 (39%)
		TRX_family	1433..>1502	CDD:239245
P4HB	XP_024306545.1	YbbN	24..394	CDD:331940	114/499 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910