DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)01289 and txndc5

DIOPT Version :9

Sequence 1:	NP_001163065.1	Gene:	l(2)01289 / 46017	FlyBaseID:	FBgn0010482	Length:	1786	Species:	Drosophila melanogaster
Sequence 2:	XP_005162560.1	Gene:	txndc5 / 406289	ZFINID:	ZDB-GENE-040426-1951	Length:	403	Species:	Danio rerio

Alignment Length:	491	Identity:	97/491 - (19%)
Similarity:	160/491 - (32%)	Gaps:	170/491 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1105 DIDDEEEVLDWLTSPANMEMTDHIEQVNRKMFEKIRKNSDYVAVIFYSDECKQCPRVLAEVEHID 1169
            |.|.||:           |...|...|  :||......:.:. |:|::..|..|.|:......:.
Zfish    21 DNDTEED-----------EHAKHTYTV--EMFNDAISTAPHF-VMFFAPWCGHCQRLQGTWNELA 71

  Fly  1170 D-----EADKAGIDFVKIDDKQMAK----EYGVFALPAIVFFKPTSKEPVIYAG--DLYEEEQIL 1223
            |     ||..|.:  ||:|..:..|    |:|:...|.:..||| .:|.|.|.|  ||   :.:.
Zfish    72 DKYNSMEAPPAYV--VKVDCTKDTKFCSIEHGIRGYPTLKLFKP-EQEAVKYQGPRDL---QALE 130

  Fly  1224 TWLI--TQKDPSGDVIEDLEGERLVHLIEESGSIAVYFWNKTKCDICNSKAARKARLKKERDQHQ 1286
            .|::  .|::|     |:.:.|.....:.|                                  .
Zfish   131 NWMLKTLQEEP-----EEPQSEPEPPKVPE----------------------------------P 156

  Fly  1287 QEGGAASAAAAFGSEADPSEAAAGGAE----DAPAAGSEGDSPPASAAAPADASTGKQEDDADGC 1347
            ::|.....|..|.|.      .|.|:.    .||..|.      ..|.||.             .
Zfish   157 KQGLYELTATNFKSH------IAKGSHFVKFFAPWCGH------CKAMAPT-------------W 196

  Fly  1348 EQCTKVLEELENI---DDDCDKHGITFVKTRDFSVADGYGVHEYPALVYFEGG------------ 1397
            ||.....|..::|   ..||.:|         :.|.....|..||.|::|..|
Zfish   197 EQLASSFEHSDSIKISKVDCTQH---------YEVCSDNQVRGYPTLLFFTDGEKIDQYKGKRDL 252

  Fly  1398 ------IPNVFEGELSEEE---------EVLQWLITQKTEDRIELITRQML-ETMVEETQYLAVY 1446
                  :.|..:...|::|         |:......:|.|..:.::|.... ||:.:...:  :.
Zfish   253 DSFKEFVDNHVKAAESKDEPEKEEEHTHEIPPSAEPEKQESNVLVLTESNFDETVAKGLSF--IK 315

  Fly  1447 FYKINCNICDQI--------------LEGLELIDDECDVFGIHMVKIQDPQLAKRYSIKTFPALV 1497
            ||...|..|..:              |..:::...:|.|         :..|..|:|::.:|.|:
Zfish   316 FYAPWCGHCKNLAPTWDDLSQKEFPGLTDVKIAKVDCTV---------ERTLCNRFSVRGYPTLL 371

  Fly  1498 YFRNGNPLLFEGDLQNEQSVLEWLIDDDNRELADEI 1533
            .||.|.    :|:..|....||.|.....::..||:
Zfish   372 MFRAGQ----QGEEHNGGRDLESLHSFIMKQARDEL 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259
		Thioredoxin_6	510..689	CDD:404691
		ER_PDI_fam	700..>916	CDD:273457
		PDI_a_family	1129..1226	CDD:239259	28/107 (26%)
		TRX_family	1433..>1502	CDD:239245	16/83 (19%)
txndc5	XP_005162560.1	ER_PDI_fam	33..403	CDD:273457	90/466 (19%)
		Thioredoxin_like	34..133	CDD:294274	28/107 (26%)
		PDI_a_ERp46	159..259	CDD:239303	26/133 (20%)
		PDI_a_ERp46	294..395	CDD:239303	23/115 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900