DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)01289 and pdia6

DIOPT Version :9

Sequence 1:	NP_001163065.1	Gene:	l(2)01289 / 46017	FlyBaseID:	FBgn0010482	Length:	1786	Species:	Drosophila melanogaster
Sequence 2:	NP_922915.2	Gene:	pdia6 / 322160	ZFINID:	ZDB-GENE-030131-879	Length:	440	Species:	Danio rerio

Alignment Length:	347	Identity:	71/347 - (20%)
Similarity:	124/347 - (35%)	Gaps:	99/347 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1421 TEDRIELITRQMLETMVEETQYLAVYFYKINCNICDQI----------LEGLELIDDECDVFGIH 1475
            ::|.:||........:::......|.||...|..|..:          |:|:
Zfish    24 SDDVVELNPSNFNREVIQSDSLWLVEFYAPWCGHCKSLAPEWKKAATALKGI------------- 75

  Fly  1476 MVKI------QDPQLAKRYSIKTFPALVYFRNGN---PLLFEGDLQNEQSV------LEWLIDD- 1524
             ||:      |...|..:|.::.||.:..| .||   |..::|...|:..|      |..|:.|
Zfish    76 -VKVGAVDADQHNSLGGQYGVRGFPTIKIF-GGNKHKPEDYQGGRTNQAIVDAALNALRSLVKDR 138

  Fly  1525 ------------------DNRELADEIEEVNERMLDRLMAES-TLLVVFFYDDDCAECEEI---- 1566
                              .|::   ::.|:.:...||.:.|| .:.:|.|:...|..|:.:
Zfish   139 LGGKTGGSDYSRQSGGGAGNKK---DVVELTDDNFDRTVLESDDVWLVEFFAPWCGHCKNLEPEW 200

  Fly  1567 ----LEELEEIDGEADMFGIDFVKIASIQA------AKKYEIVNIPSLVYFRK-QVPVLYDGDLH 1620
                .|..|:..|:        |::|:..|      |.::.|...|::..||| :.|..|.|...
Zfish   201 TAAATEVKEQTKGK--------VRLAAEDATVHQGLASRFGIRGFPTIKVFRKGEEPEDYQGGRT 257

  Fly  1621 QHDKVITWLTSQDVFEIKNEIEEV-NRKMLDKLLEENEFLAVFFYEHNQPDSTAALEKLENIDSE 1684
            :.|.|...|..........|::|| |..:|.|..|:.:...:           |.|..:.:..:.
Zfish   258 RSDIVARALELYSDNIPAPELQEVLNEGILKKTCEDYQLCII-----------AVLPHILDTGAS 311

  Fly  1685 TDNLDITFVK-MADSRYAKKWG 1705
            ..|..:..:| ||:....|.||
Zfish   312 GRNSYLEVMKTMAEKHKKKMWG 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259
		Thioredoxin_6	510..689	CDD:404691
		ER_PDI_fam	700..>916	CDD:273457
		PDI_a_family	1129..1226	CDD:239259
		TRX_family	1433..>1502	CDD:239245	15/84 (18%)
pdia6	NP_922915.2	ER_PDI_fam	25..262	CDD:273457	53/262 (20%)
		PDI_a_P5	26..128	CDD:239299	24/116 (21%)
		PDI_a_P5	161..266	CDD:239299	26/112 (23%)
		P5_C	275..404	CDD:239281	16/70 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900