Protein Alignment hlk and Erp27

DIOPT Version :10

• Sequence 1: NP_001163065.1
• Gene: hlk / 46017
• FlyBaseID: FBgn0010482
• Length: 1786
• Species: Drosophila melanogaster
• Sequence 2: NP_001100095.1
• Gene: Erp27 / 297698
• RGDID: 1565381
• Length: 272
• Species: Rattus norvegicus
• Alignment Length: 277
• Identity: 61/277 - (22%)
• Similarity: 107/277 - (38%)
• Gaps: 84/277 - (30%)

  Fly   196 CRKCAKALQELENIDDEADQLGIGFVKIHDEALADEYNLGNLPALV-------------YYRHQT 247
            ||...:|..::|...:     |:|..:       :...|.::||.|             :...:.
  Rat    17 CRLVPEATADVEETSE-----GLGTPR-------EPRWLTDIPATVELIAAAEVAVIGFFQDLEI 69

  Fly   248 PI--IYEGELQREEDVLEWLVQNKSTGDEDDVIE--DVTSKTLSTLISNIDNLVVLFYDHGNDDS 308
            ||  |:....|:.:|| .:.:.|.|     :|:.  :|||.:: .|...:||..:..
  Rat    70 PIVSIFRSMAQQFQDV-SFGISNHS-----EVLTHYNVTSNSI-CLFRLVDNKQLRL-------- 119

  Fly   309 MTVLEELEQIDD-DCDKHGIQFVKIDDAKAAADYGIDSIPAI--------------VYFEKEIPN 358
                 :.|.||| |..|.. :|:.:::.....:|.    |.|              :...|..|.
  Rat   120 -----DAEDIDDLDAAKLS-RFIHLNNLHWVTEYS----PMIGAGLFNTMVQTHLLLIMNKASPE 174

  Fly   359 VYDGDLMDEEQILKWLLGQLERDEIEDVTDEMLDTMIKE-GRVIAVLFYDNNDKKSQ-KVLEELE 421
             |:..|...::..|...||        :...::|:..:| |:|||..    ..|:|| ..|...|
  Rat   175 -YEESLRSYQKAAKLFQGQ--------ILFVLVDSGKRENGKVIAYF----RLKESQLPALAIYE 226

  Fly   422 NIDDECDALGITFVKID 438
            ::||:.|||.||.|.::
  Rat   227 SVDDKWDALTITEVTVE 243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hlk	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		ER_PDI_fam	381..>670	CDD:273457	19/60 (32%)
		PDI_a_family	384..479	CDD:239259	19/57 (33%)
		ER_PDI_fam	700..>916	CDD:273457
		PDI_a_family	1129..1226	CDD:239259
		TRX_family	1433..>1502	CDD:239245
Erp27	NP_001100095.1	Thioredoxin_6	64..250	CDD:463999	51/218 (23%)