Protein Alignment l(2)01289 and PDIA3

DIOPT Version :9

• Sequence 1: NP_001163065.1
• Gene: l(2)01289 / 46017
• FlyBaseID: FBgn0010482
• Length: 1786
• Species: Drosophila melanogaster
• Sequence 2: NP_005304.3
• Gene: PDIA3 / 2923
• HGNCID: 4606
• Length: 505
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 107/560 - (19%)
• Similarity: 200/560 - (35%)
• Gaps: 169/560 - (30%)

  Fly   673 ALYEGDLMNEDEVLEWLLVQKKTAT---IEEVTDEILVTLINEHE----YVVVFFTGPCEPGETC 730
            ||:.|        :..||...:.|.   :.|:||:...:.|::..    .:|.||...|  |. |
Human     7 ALFPG--------VALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWC--GH-C 60

  Fly   731 EHTLNALESIDDELDEAGIIFVT----TEDTGIAKKYNVKTYPRLVFFRNRDPLHFTGDLD---D 788
            :......|:....|  .||:.:.    |.:|....||.|..||.|..||:.:.   .|..|   .
Human    61 KRLAPEYEAAATRL--KGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEE---AGAYDGPRT 120

  Fly   789 EDEVLAWITDDE-TLEIPGKIEEVNVKMLDKILAENDHVVVFFYAEGDKKA-QKILNELENIDDE 851
            .|.:::.:.... ...:|.:.||    ...|.:::.|..:|.|:.:...:| .:.|....|:.|
Human   121 ADGIVSHLKKQAGPASVPLRTEE----EFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRD- 180

  Fly   852 CEEKDIDFVKTSDDDIDKEYDLPGLPALAF----YRHKF--RTI-YTGDLMKEEEILEWVID--- 906
                :..|..|:.:.:..|||..|...:.|    ..:||  :|: ||...|...:|.:::.:
Human   181 ----NYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIF 241

  Fly   907 -----LHESTADVIESVDRKTLQVLINDVEHLAVFFYDDECESCSD---------ILEELENIDD 957
                 :.|...|:|:..|             |.:.:||.:.|..:.         ::...:.:|.
Human   242 GICPHMTEDNKDLIQGKD-------------LLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDA 293

  Fly   958 DTDKHGIQFVKSNDVKLAHEIGIFAFPALVYYETGVPIM-------------------------- 996
            .   |.:.|..::....:||:..|...:..   ..:|::
Human   294 G---HKLNFAVASRKTFSHELSDFGLESTA---GEIPVVAIRTAKGEKFVMQEEFSRDGKALERF 352

  Fly   997 ----YDGNI----------ASNQDVFNWILEQKADQSIQLINRDQLFEYIGTKDFLAVVFYKEDD 1047
                :|||:          .||......::.:..|:.:...|:|.|.|           ||
Human   353 LQDYFDGNLKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIE-----------FY---- 402

  Fly  1048 PDSPRVLRHIELIDDEAAEYGIYIVKMHDKLMAKKYGFRNPPGLTYFRKGKYINYDGDIDDEEEV 1112
              :| ...|.:.::.:..|.|..:.|..:.::||.....|                 |:....||
Human   403 --AP-WCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATAN-----------------DVPSPYEV 447

  Fly  1113 LDWLT---SPANMEMTDHIEQVNRKMFEKIRKNSDYVAVI 1149
            ..:.|   ||||       :::|.|.:|..|:.||:::.:
Human   448 RGFPTIYFSPAN-------KKLNPKKYEGGRELSDFISYL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259
		Thioredoxin_6	510..689	CDD:404691	3/15 (20%)
		ER_PDI_fam	700..>916	CDD:273457	54/243 (22%)
		PDI_a_family	1129..1226	CDD:239259	6/21 (29%)
		TRX_family	1433..>1502	CDD:239245
PDIA3	NP_005304.3	YbbN	25..487	CDD:331940	101/534 (19%)
		ER retention motif	502..505

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910