DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)01289 and Pdia6

DIOPT Version :9

Sequence 1:	NP_001163065.1	Gene:	l(2)01289 / 46017	FlyBaseID:	FBgn0010482	Length:	1786	Species:	Drosophila melanogaster
Sequence 2:	NP_001004442.1	Gene:	Pdia6 / 286906	RGDID:	628688	Length:	445	Species:	Rattus norvegicus

Alignment Length:	395	Identity:	84/395 - (21%)
Similarity:	141/395 - (35%)	Gaps:	101/395 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1421 TEDRIELITRQMLETMVEETQYLAVYFYKINCNICDQIL----EGLELIDDECDVFGIHMVKIQD 1481
            ::|.|||........:::......|.||...|..|.::.    :....:.|...|..::..|.|
  Rat    29 SDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAASALKDVVKVGAVNADKHQ- 92

  Fly  1482 PQLAKRYSIKTFPALVYF--RNGNPLLFEGDLQNEQ------SVLEWLIDD-------------- 1524
             .|..:|.::.||.:..|  ....|..::|....|.      |.|..|:.|
  Rat    93 -SLGGQYGVQGFPTIKIFGANKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQ 156

  Fly  1525 ---DNRELADEIEEVNERMLDRLMAESTLLVVFFYDDDCAECEEI--------LEELEEIDGEAD 1578
               |:....|.:|..::.....::....:.:|.||...|..|:.:        .|..|:..|:
  Rat   157 GRGDSSSKKDVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGK-- 219

  Fly  1579 MFGIDFVKIASIQA------AKKYEIVNIPSLVYFRK-QVPVLYDGDLHQHDKVITWLTSQDVF- 1635
                  ||:|::.|      |.:|.|...|::..|:| :.||.|||...:.|.|...|   |:|
  Rat   220 ------VKLAAVDATVNQVLASRYGIKGFPTIKIFQKGESPVDYDGGRTRSDIVSRAL---DLFS 275

  Fly  1636 ------EIKNEIEEVNRKMLDKLLEENEFLAVFFYEH-NQPDSTAALEKLENIDSETDNLDITFV 1693
                  |:   :|.:|..:..|..||::...|....| ....:|.....||           ..:
  Rat   276 DNAPPPEL---LEIINEDIAKKTCEEHQLCVVAVLPHILDTGATGRNSYLE-----------VLL 326

  Fly  1694 KMADSRYAKKWGVT-------------------KLPAM--VYFRRRFPSIYRGDLLSEDEVLEWL 1737
            |:||....|.||..                   ..|||  :..|:...::.:|. .||..:.|:|
  Rat   327 KLADKYKKKMWGWLWTEAGAQYELENALGIGGFGYPAMAAINARKMKFALLKGS-FSEQGINEFL 390

  Fly  1738 RKNRF 1742
            |:..|
  Rat   391 RELSF 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259
		Thioredoxin_6	510..689	CDD:404691
		ER_PDI_fam	700..>916	CDD:273457
		PDI_a_family	1129..1226	CDD:239259
		TRX_family	1433..>1502	CDD:239245	14/74 (19%)
Pdia6	NP_001004442.1	PDI_a_P5	31..133	CDD:239299	21/103 (20%)
		PDI_a_P5	166..271	CDD:239299	27/112 (24%)
		P5_C	280..409	CDD:239281	28/131 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810