Protein Alignment l(2)01289 and PDILT

DIOPT Version :9

• Sequence 1: NP_001163065.1
• Gene: l(2)01289 / 46017
• FlyBaseID: FBgn0010482
• Length: 1786
• Species: Drosophila melanogaster
• Sequence 2: NP_777584.1
• Gene: PDILT / 204474
• HGNCID: 27338
• Length: 584
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 124/591 - (20%)
• Similarity: 225/591 - (38%)
• Gaps: 169/591 - (28%)

  Fly   378 LERDEIEDVTDEMLDTMIKEGRVIAVLFYDNNDKKSQKVLEEL----------ENIDDECDALGI 432
            ||...:..:|...|..|:.:.|.:.|||::.:.|:|:.:.|||          :|        ||
Human    40 LEERSLLVLTPAGLTQMLNQTRFLMVLFHNPSSKQSRNLAEELGKAVEIMGKGKN--------GI 96

  Fly   433 TFVKID---NPEEAVEYGINKVPKL-IYFE--KGIPTIYEGNLEDEEKLLKWLTDQTSSDQ-IED 490
            .|.|:|   ..|...|:||.|.|:| ::||  :..|...:|.:| ...|:.||..|.|... :.:
Human    97 GFGKVDITIEKELQQEFGITKAPELKLFFEGNRSEPISCKGVVE-SAALVVWLRRQISQKAFLFN 160

  Fly   491 ITDEMLDLIIEKMPHVAVLFYDKDQKKSQKILAELENIDDECDQNDIAFVKIDDDKEAKEWGIDE 555
            .::::.:.:|.:...:...|.|.:::     :|||             |..:..|.....:|:..
Human   161 SSEQVAEFVISRPLVIVGFFQDLEEE-----VAEL-------------FYDVIKDFPELTFGVIT 207

  Fly   556 IPSIVLFERGIPHI--------YEGDLMKEDELLGWLVHQKRYSEIPEVTDEMKDKLVE-NTEHL 611
            |.:::    |..|:        .:|.::...:|:....:::..:.:  :...:.|.::| |||
Human   208 IGNVI----GRFHVTLDSVLVFKKGKIVNRQKLINDSTNKQELNRV--IKQHLTDFVIEYNTE-- 264

  Fly   612 AVIFYDKDDKQDMRILNE-LENIDDELEKEGIVIVRIDNAAEAKEYGLDHLPALI---------- 665
                 :||...::.|::. |..:....|..||:|.....|  :||:....|..|:
Human   265 -----NKDLISELHIMSHMLLFVSKSSESYGIIIQHYKLA--SKEFQNKILFILVDADEPRNGRV 322

  Fly   666 --YF---ENKIPALYEGDL-------MNEDEVLEWLLVQ------KKTATIEEVTDEI------- 705
              ||   |..||::...:|       |..|::....|.:      .|.||..:.::||
Human   323 FKYFRVTEVDIPSVQILNLSSDARYKMPSDDITYESLKKFGRSFLSKNATKHQSSEEIPKYWDQG 387

  Fly   706 -LVTLINEHEYVVVF---------FTGPCEPGETCEHTLNALESIDDELDEAGIIFVTTEDTGIA 760
             :..|:.::..||||         |..|.  .:.|:.....||.:..:......|.:...|. .|
Human   388 LVKQLVGKNFNVVVFDKEKDVFVMFYAPW--SKKCKMLFPLLEELGRKYQNHSTIIIAKIDV-TA 449

  Fly   761 KKYNVKTYPRLVFFR-----NRDPLHFTGD-----------------LDDEDEVLAWITDDETLE 803
            ....:....|..|||     ::..:.:.|:                 ::||||:|: :..:|.:|
Human   450 NDIQLMYLDRYPFFRLFPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIEDEDELLS-VEQNEVIE 513

  Fly   804 IPGKIEEVNVKMLDKILAE--------------------------NDHVVVFFYAEG---DKKAQ 839
            .....||..|.|:.|.|.|                          .:.|||....:|   .||..
Human   514 EEVLAEEKEVPMMRKGLPEQQSPELENMTKYVSKLEEPAGKKKTSEEVVVVVAKPKGPPVQKKKP 578

  Fly   840 KILNEL 845
            |:..||
Human   579 KVKEEL 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259	31/110 (28%)
		Thioredoxin_6	510..689	CDD:404691	39/210 (19%)
		ER_PDI_fam	700..>916	CDD:273457	43/214 (20%)
		PDI_a_family	1129..1226	CDD:239259
		TRX_family	1433..>1502	CDD:239245
PDILT	NP_777584.1	YbbN	46..501	CDD:331940	100/499 (20%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	581..584		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810