DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)01289 and pdi-6

DIOPT Version :9

Sequence 1:	NP_001163065.1	Gene:	l(2)01289 / 46017	FlyBaseID:	FBgn0010482	Length:	1786	Species:	Drosophila melanogaster
Sequence 2:	NP_509190.1	Gene:	pdi-6 / 180974	WormBaseID:	WBGene00015168	Length:	440	Species:	Caenorhabditis elegans

Alignment Length:	388	Identity:	69/388 - (17%)
Similarity:	143/388 - (36%)	Gaps:	89/388 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1420 KTEDRIELITRQMLETMVEETQYLAVYFYKINCNICDQIL----EGLELIDDECDVFGIHMVKIQ 1480
            |.:|.:||........::.......|.||...|..|..::    :....:.....|..:.|.  |
Worm    22 KKDDVVELTEANFQSKVINSDDIWIVEFYAPWCGHCKSLVPEYKKAASALKGVAKVGAVDMT--Q 84

  Fly  1481 DPQLAKRYSIKTFPALVYF--RNGNPLLFEGDLQNEQSVLEWLIDDDNRELA------------- 1530
            ...:...|:::.||.|..|  ....|..:.|. :..|::.:.::.:..:.::
Worm    85 HQSVGGPYNVQGFPTLKIFGADKKKPTDYNGQ-RTAQAIADSVLAEAKKAVSARLGGKSSGSSSS 148

  Fly  1531 ---------------DEIEEVNERMLDRLMAES-TLLVVFFYDDDCAECEEILEE----LEEIDG 1575
                           :|:.|:.:...:.|:..| .:.:|.|:...|..|:.:..:    ..|:.|
Worm   149 GSGSGSGKRGGGGSGNEVVELTDANFEDLVLNSKDIWLVEFFAPWCGHCKSLEPQWKAAASELKG 213

  Fly  1576 EADMFGIDFVKIASIQ--AAKKYEIVNIPSLVYFRKQVPVL----YDGDLHQHDKVITWLT--SQ 1632
            :..:..:|    |::.  .|.|:.|...|::.||.....|.    |||. .|...::.|.:  :|
Worm   214 KVRLGALD----ATVHTVVANKFAIRGFPTIKYFAPGSDVSDAQDYDGG-RQSSDIVAWASARAQ 273

  Fly  1633 DVFEIKNEIEEVNRKMLDKLLEENEFLAVFFYEHNQPDSTAALEKLENIDSETDNLDITFVKMAD 1697
            :........|.:|:::::...:|.: |.:|          |.|..:.:..||..|..:..:|...
Worm   274 ENMPAPEVFEGINQQVVEDACKEKQ-LCIF----------AFLPHILDCQSECRNNYLAMLKEQS 327

  Fly  1698 SRYAKK-WGVTKL-------------------PAM--VYFRRRFPSIYRGDLLSEDEVLEWLR 1738
            .::.|. ||...:                   |||  :.||:...::.:|. ..:|.:.|:||
Worm   328 EKFKKNLWGWIWVEGAAQPALEESFEVGGFGYPAMTALNFRKNKYAVLKGS-FGKDGIHEFLR 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259
		Thioredoxin_6	510..689	CDD:404691
		ER_PDI_fam	700..>916	CDD:273457
		PDI_a_family	1129..1226	CDD:239259
		TRX_family	1433..>1502	CDD:239245	13/74 (18%)
pdi-6	NP_509190.1	PDI_a_P5	25..127	CDD:239299	19/104 (18%)
		PDI_a_P5	165..269	CDD:239299	24/108 (22%)
		P5_C	278..407	CDD:239281	24/124 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900