DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)01289 and Y49E10.4

DIOPT Version :9

Sequence 1:	NP_001163065.1	Gene:	l(2)01289 / 46017	FlyBaseID:	FBgn0010482	Length:	1786	Species:	Drosophila melanogaster
Sequence 2:	NP_499613.1	Gene:	Y49E10.4 / 176664	WormBaseID:	WBGene00013030	Length:	436	Species:	Caenorhabditis elegans

Alignment Length:	447	Identity:	91/447 - (20%)
Similarity:	154/447 - (34%)	Gaps:	113/447 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   697 TIEEVTDEIL--VTLINEHEYVVVFFTGPCEPGETCEHTLNALESIDDELDEAGIIFVTTEDTGI 759
            ::.|:||...  ..|.::..::|.|:...|...::..........:...:.|.|.|..|.... |
Worm    25 SVFELTDSNFDAKVLKSDRIWIVEFYAPYCGHCKSLVPEYKKAAKLLKGIAEIGAIDATVHQK-I 88

  Fly   760 AKKYNVKTYPRLVFF---RNRDPLHFTGDLDDE---DEVLAWITDDETLEIPGKIEEVNVKM--- 815
            ..||::|.||.:..|   ....|:.:.|....:   |.|...|.......:.||..|.:.|.
Worm    89 PLKYSIKGYPTIKIFGATEKSKPIDYNGPRTAKGIADAVKKSIEKSLEQRLKGKSSEKSKKSDKK 153

  Fly   816 ----------LDK-ILAENDHVVVFFYAEGDKKAQKILNELENIDDECEEKDIDFVK------TS 863
                      .|| :|...:..:|.|:|......||:..|.:...:|...:    ||      |:
Worm   154 GKVVVLTDSNFDKLVLNSKEPWMVEFFAPWCGHCQKLEPEWKKAAEEMGGR----VKFGALDATA 214

  Fly   864 DDDIDKEYDLPGLPALAFYRHKFRTI-----YTGDLMKEEEI--LEWVIDLHESTADVIESVDRK 921
            .:.|.:::.:.|.|.:.|:.....:.     |.|.....:.|  .|...|...:..:|:|...:.
Worm   215 HESIAQKFGIRGFPTIKFFAPGTSSASDAEDYQGGRTSTDLISYAESKYDDFGAAPEVVEGTGKA 279

  Fly   922 TLQVLINDVEHLAVFFYDD---ECES-CS----DILEELENIDDDTDKHGIQFV-----KSNDVK 973
            .::.:..| :.|.:|.:..   :|:| |.    |:|.||..|   ..|....:|     ...:|:
Worm   280 VVETVCKD-KQLCIFTFLPSIFDCQSKCRKQKIDMLNELATI---FKKRSFGWVWMEGGAQENVQ 340

  Fly   974 LAHEIGIFAFPALVYYETGVPIMYDGNIASNQDVFNWILEQKADQSIQLINRDQLFEYIGTKDFL 1038
            .|.|||.:.||.|:.. :...:||...|..                         |...|.|:||
Worm   341 RAFEIGDYGFPVLIAM-SPKKMMYSTQIGQ-------------------------FSVDGIKEFL 379

  Fly  1039 AVVFYKE--------------------------DDPDSPRVLRHIELID---DEAAE 1066
            ..|.|.:                          .|.:.| |:..|:|.|   ||..|
Worm   380 NAVNYGKGRVLEIKPTHLSNNFLKIVETQPWDGKDKELP-VMEDIDLSDVDMDEKTE 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259
		Thioredoxin_6	510..689	CDD:404691
		ER_PDI_fam	700..>916	CDD:273457	50/250 (20%)
		PDI_a_family	1129..1226	CDD:239259
		TRX_family	1433..>1502	CDD:239245
Y49E10.4	NP_499613.1	PDI_a_P5	26..127	CDD:239299	21/101 (21%)
		PDI_a_P5	156..259	CDD:239299	20/106 (19%)
		P5_C	269..405	CDD:239281	33/165 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900