DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)01289 and D2092.4

DIOPT Version :9

Sequence 1:	NP_001163065.1	Gene:	l(2)01289 / 46017	FlyBaseID:	FBgn0010482	Length:	1786	Species:	Drosophila melanogaster
Sequence 2:	NP_491903.2	Gene:	D2092.4 / 172378	WormBaseID:	WBGene00017065	Length:	363	Species:	Caenorhabditis elegans

Alignment Length:	323	Identity:	80/323 - (24%)
Similarity:	134/323 - (41%)	Gaps:	79/323 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   908 HESTADVIESVDRKTLQVLINDV-EHLAVFFYDDE--CESCSDILEELENIDDDTDKHG-IQFVK 968
            |:...:.|:.||...:..::.|. ::|.:|.||.:  |.:|::.|.|:|.||||.:..| :|.||
Worm    70 HKDDDNSIDDVDEDRIDEILRDASKNLVIFLYDGKVPCPTCTEALSEVEEIDDDIEATGYVQVVK 134

  Fly   969 SNDVKLAHEIGIFAFPALVYYETGVPIMYDGNIASNQDVFNWILEQKADQSIQLIN-RDQLFEY- 1031
            :||..:|.|:||..||:||||....||:|||:...::.:..|:   :|.:.:...: .|..||.
Worm   135 TNDRSVARELGINVFPSLVYYRRKNPILYDGDFKDSETLLRWL---RAHEEVATWDLTDDTFESR 196

  Fly  1032 -------IGTKDFLAVVFYKEDDPDSP------RVLRH----------IEL-IDDEAAEYGIYIV 1072
                   .|:.|:. |:||..|:.:|.      ..:.|          ||: ::|:..|
Worm   197 TDSHSPDEGSIDWF-VMFYDADEGNSNAFVPLWETVAHKLRGLVNVGKIEISVNDDVTE------ 254

  Fly  1073 KMHDKLMAKKYGFRNPPGLTYFRKGKYINYDGDIDDEEEVLDWLTSPANMEMTDHIEQVNRKMFE 1137
            :.|.:       .|:.|....|.:||...|.....|..       |..|..:..:.||...::
Worm   255 RFHIE-------ERDCPVFLLFHRGKMYRYKESAKDAR-------SLTNFALHKYKEQRGHRV-- 303

  Fly  1138 KIRKNSDYVAVIFYSDECKQCPRVLAEVEHIDDEADKAGIDFVKIDDKQMAKEYGVFALPAIV 1200
                                 |.....:|.:.:.|.:..:|.  :||.|.....||..|..||
Worm   304 ---------------------PEPPTAIEQVYEFAKEKIMDI--MDDNQTLSVLGVGGLIVIV 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259
		Thioredoxin_6	510..689	CDD:404691
		ER_PDI_fam	700..>916	CDD:273457	1/7 (14%)
		PDI_a_family	1129..1226	CDD:239259	14/72 (19%)
		TRX_family	1433..>1502	CDD:239245
D2092.4	NP_491903.2	Thioredoxin_like	92..177	CDD:381987	34/84 (40%)
D2092.4	NP_491903.2	PTZ00443	188..>316	CDD:185622	29/171 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166368
Domainoid	1	1.000	79	1.000	Domainoid score	I5609
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19991
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840