DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)01289 and Pdia4

DIOPT Version :9

Sequence 1:	NP_001163065.1	Gene:	l(2)01289 / 46017	FlyBaseID:	FBgn0010482	Length:	1786	Species:	Drosophila melanogaster
Sequence 2:	NP_001355685.1	Gene:	Pdia4 / 12304	MGIID:	104864	Length:	699	Species:	Mus musculus

Alignment Length:	811	Identity:	160/811 - (19%)
Similarity:	274/811 - (33%)	Gaps:	227/811 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RLKTLSLLVCALLALSFPGHVSGAGNNNNKKGSQPVAPPEPEAVIEE---------------VNA 54
            :|:...||| .||||:.....:.||:.:........|..|.|...||               :|.
Mouse     2 KLRKAWLLV-LLLALTQLLAAASAGDAHEDTSDTENATEEEEEEEEEDDDDLEVKEENGVWVLND 65

  Fly    55 KQLEKLLADKDYVAVFWYARSCVTCDKVLAELEKI-----DDDTDSFGVDFVKINDKRLAKQYGI 114
            ...:..:||||.|.:.:||..|..|.:...|.|||     |:|...........:...||.::.:
Mouse    66 GNFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIAVAKIDATSASMLASKFDV 130

  Fly   115 KNFPALTYFREKEPIIYDGDLMDEEGVLDFLTSLEAMDLPDRI--EEVNAKI----LQKIIEDTD 173
            ..:|.:...::.:.:.|||....||    .:..:..:..||..  .||...:    ...::.:.|
Mouse   131 SGYPTIKILKKGQAVDYDGSRTQEE----IVAKVREVSQPDWTPPPEVTLSLTKDNFDDVVNNAD 191

  Fly   174 FVAVLF---------------------CPDHE-------------------------TCPPRVMD 192
            .:.|.|                     ...|.                         :..||...
Mouse   192 IILVEFYAPWTVALLLFSLSFYQFAVLLSTHTGLLDVNANDKSLMFQQFSVPVGPVLSFSPRRHS 256

  Fly   193 KQQCRKCAKALQELENIDDEADQLG--IGFVKI---HDEALADEYNLGNLPALVYYRHQTPIIYE 252
            |..|..|.|...|.|....|..:..  |...|:   ....||..:::...|.|..:|...|..|.
Mouse   257 KIWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATEQTDLAKRFDVSGYPTLKIFRKGRPFDYN 321

  Fly   253 GELQREE-DVLEWLVQNKSTGDEDDVIEDVTSKTLSTLISNIDNLVV--LFYDHGNDDSMTVLEE 314
            |  .||: .:::::::......:    |.:|.|.:...:.:.|::|:  ||...|:...:...:.
Mouse   322 G--PREKYGIVDYMIEQSGPPSK----EILTLKQVQEFLKDGDDVVIIGLFQGDGDPAYLQYQDA 380

  Fly   315 LEQIDDDCDKHG------IQFVKIDDAKAAADYGIDSIPAIVYFEKEIPNVYDG--DLMDEEQIL 371
            ...:.:|...|.      .:|:|:...|           .::...::..:.|:.  .:||.:
Mouse   381 ANNLREDYKFHHTFSPEIAKFLKVSLGK-----------LVLTHPEKFQSKYEPRFHVMDVQ--- 431

  Fly   372 KWLLGQLERDEIEDVTDEMLDTMIKEGRVIAVLFYDNNDKK--SQKVLEELENIDDECDALGITF 434
                |..|...|:|.       ::|....:......:||.|  |::             .|.:.:
Mouse   432 ----GSTEASAIKDY-------VVKHALPLVGHRKTSNDAKRYSKR-------------PLVVVY 472

  Fly   435 VKID---NPEEAVEYGINKVPKLIYFEKGIPTIYEGNLEDEEKLLKWLTDQTSSDQIEDITDEML 496
            ..:|   :...|.::..|||   :...|..|. |...:.|||.....:.|...|:..||:...:|
Mouse   473 YSVDFSFDYRAATQFWRNKV---LEVAKDFPE-YTFAIADEEDYATEVKDLGLSESGEDVNAAIL 533

  Fly   497 DLIIEKMPHVAVLFYDKDQKKSQKILAELENIDDECDQNDIAFVKIDDDKEAKEWGIDEIPSIVL 561
            |                  :..:|...|.|..|.:..:..:...|....|.            |:
Mouse   534 D------------------ESGKKFAMEPEEFDSDTLREFVTAFKKGKLKP------------VI 568

  Fly   562 FERGIPHIYEGDLMKEDELLGWLVHQKRYSEIPEVTDEMKDKLVENTEHLAVIFYDK---DDKQD 623
            ..:.:|...:|.:.        :|..|.:..|  |.|..||.|:|        ||..   ..||
Mouse   569 KSQPVPKNNKGPVK--------VVVGKTFDAI--VMDPKKDVLIE--------FYAPWCGHCKQ- 614

  Fly   624 MRILNELENIDDELEK-----EGIVIVRID---NAAEAKEYGLDHLPALIYF----ENKIPALYE 676
                  ||.|...|.|     :.:||.::|   |.....:|.::..|. |||    :.|.|..:|
Mouse   615 ------LEPIYTSLGKKYKGQKDLVIAKMDATANDITNDQYKVEGFPT-IYFAPSGDKKNPIKFE 672

  Fly   677 GDLMNEDEVLEWLL------VQKKTATIEEV 701
            |.  |.|  ||.|.      ..|::.|.||:
Mouse   673 GG--NRD--LEHLSKFIDEHATKRSRTKEEL 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259	26/114 (23%)
		PDI_a_family	384..479	CDD:239259	18/99 (18%)
		Thioredoxin_6	510..689	CDD:404691	44/193 (23%)
		ER_PDI_fam	700..>916	CDD:273457	1/2 (50%)
		PDI_a_family	1129..1226	CDD:239259
		TRX_family	1433..>1502	CDD:239245
Pdia4	NP_001355685.1	pdi_dom	63..164	CDD:273454	24/104 (23%)
Pdia4	NP_001355685.1	ER_PDI_fam	173..691	CDD:273457	115/625 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910