Protein Alignment hlk and PDIA5

DIOPT Version :10

• Sequence 1: NP_001163065.1
• Gene: hlk / 46017
• FlyBaseID: FBgn0010482
• Length: 1786
• Species: Drosophila melanogaster
• Sequence 2: NP_006801.1
• Gene: PDIA5 / 10954
• HGNCID: 24811
• Length: 519
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 107/504 - (21%)
• Similarity: 190/504 - (37%)
• Gaps: 114/504 - (22%)

  Fly   475 LLKWLTDQTSSDQIEDITD-EMLDLIIEKMPHVAVLFYDKDQKKSQKILAELENIDDEC-DQNDI 537
            |..||:....|..||.|:| :.|..::....:|.|| |.|.:..::..|..|..:.... .|..|
Human    17 LPSWLSSAKVSSLIERISDPKDLKKLLRTRNNVLVL-YSKSEVAAENHLRLLSTVAQAVKGQGTI 80

  Fly   538 AFVKIDD---DKEAKEWGIDEIP--------------------------SIVLF---ERGIPHIY 570
            .:|...|   .|..|:..:|..|                          |||.|   .:| |.::
Human    81 CWVDCGDAESRKLCKKMKVDLSPKDKKVELFHYQDGAFHTEYNRAVTFKSIVAFLKDPKG-PPLW 144

  Fly   571 EGDLMKEDELLGWLVHQKRYSEIPEVTDEMKD--KLVENTEH-LAVIFYDKDDKQDMRILNELEN 632
            |.|...:|     :||          .|..||  :|::..|. |.::||........|::...:.
Human   145 EEDPGAKD-----VVH----------LDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQK 194

  Fly   633 IDDELEKEGIVI------VRIDNAAEAKEYGLDHLPALIYFE-NKIPALYEGDLMNEDEVLEWLL 690
            ...:|....::.      ...:|..|  ||.:...|.:.||| .:....|:......::::|||.
Human   195 AATQLRGHAVLAGMNVYSSEFENIKE--EYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIVEWLK 257

  Fly   691 VQK-------------KTATIEEVTDEILVTLINEHEYVVVFFTGPCEPGETCEHTL-------N 735
            ..:             :..::..:|||.....:.||..|:|.|..|     .|.|..       .
Human   258 NPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAP-----WCGHCKKMKPEFEK 317

  Fly   736 ALESIDDELDEAGIIFV--TTEDTGIAKKYNVKTYPRLVFFRNRD----PLHFTGDLDDEDEVLA 794
            |.|::..|.|.:|::..  .|.:..:|:::::..:|.|.:|:|.:    |:     |..:.:.|.
Human   318 AAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEKYAVPV-----LRTKKKFLE 377

  Fly   795 WITDDETLEIPGKI-EEVNVKMLDKI-------LAENDHVVVFFYAEGDKKAQKILNELENIDDE 851
            |:.:.|....|... ||....:|..:       |.:..|.:|.|||......:|::.......|.
Human   378 WMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADA 442

  Fly   852 CEE------KDIDFVKTSDDDIDKEYDLPGLPALAFYRH-KFRTIYTGD 893
            .::      ..:|.||..:.|:.::..:.|.|...:|.: ||...|..|
Human   443 FKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSD 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hlk	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		ER_PDI_fam	381..>670	CDD:273457	53/238 (22%)
		PDI_a_family	384..479	CDD:239259	1/3 (33%)
		ER_PDI_fam	700..>916	CDD:273457	50/222 (23%)
		PDI_a_family	1129..1226	CDD:239259
		TRX_family	1433..>1502	CDD:239245
PDIA5	NP_006801.1	PDI_b_PDIR_N	28..139	CDD:239365	24/111 (22%)
		PDI_a_PDIR	152..256	CDD:239295	23/120 (19%)
		PDI_a_PDIR	277..379	CDD:239295	25/111 (23%)
		PDI_a_PDIR	398..501	CDD:239295	20/94 (21%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	516..519