DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)01289 and Txndc5

DIOPT Version :9

Sequence 1:NP_001163065.1 Gene:l(2)01289 / 46017 FlyBaseID:FBgn0010482 Length:1786 Species:Drosophila melanogaster
Sequence 2:NP_663342.3 Gene:Txndc5 / 105245 MGIID:2145316 Length:417 Species:Mus musculus


Alignment Length:400 Identity:82/400 - (20%)
Similarity:137/400 - (34%) Gaps:118/400 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1290 GAASAAAAFGSEADPSEAAAGGAEDAPAAGSEGDSPPASAAAPADAST-GKQEDD------ADGC 1347
            ||...|.|...|||              :|.|.| |.|.....||..| |.|...      |..|
Mouse    26 GARKGARAQEVEAD--------------SGVEQD-PHAKHLYTADMFTHGIQSAAHFVMFFAPWC 75

  Fly  1348 EQCTKVLEELENIDD---------------DCDKHGITFVKTRDFSVADGYGVHEYPALVYFEGG 1397
            ..|.::.....::.|               ||         |.|..|....||..||.|.:|:.|
Mouse    76 GHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDC---------TADSDVCSAQGVRGYPTLKFFKPG 131

  Fly  1398 IPNV-FEGELSEEEEVLQWLITQKTEDRI------------EL------ITRQMLETMVEETQYL 1443
            ...| ::|. .:.|.:..|::....|:..            ||      ::....|..|.:..:.
Mouse   132 QEAVKYQGP-RDFETLENWMLQTLNEEPATPEPEAEPPRAPELKQGLYELSANNFELHVSQGNHF 195

  Fly  1444 AVYFYKINCNIC-------DQILEGLELIDDECDVFGIHMVKI------QDPQLAKRYSIKTFPA 1495
             :.|:...|..|       :|:..|||..:         .|||      |...:...:.::.:|.
Mouse   196 -IKFFAPWCGHCKALAPTWEQLALGLEHSE---------TVKIGKVDCTQHYAVCSEHQVRGYPT 250

  Fly  1496 LVYFRNGNPL--------------LFEGDLQNEQSVLEWLIDDDNRELADE-------IEEVNER 1539
            |::||:|..:              ..:..||..::..|.:...:...:|.|       :..:.|:
Mouse   251 LLWFRDGKKVDQYKGKRDLESLRDYVQSQLQGSEAAPETVEPSEAPVMAAEPTGDKGTVLALTEK 315

  Fly  1540 MLDRLMAESTLLVVFFYDDDCAECEEILEELEEIDGEADMFGIDFVKIASI------QAAKKYEI 1598
            ..:..:|:. :..|.||...|..|:.:....||: .:.:..|:..|.||.:      ....||.:
Mouse   316 SFEDTIAQG-ITFVKFYAPWCGHCKNLAPTWEEL-SKKEFPGLSDVTIAEVDCTAERNVCSKYSV 378

  Fly  1599 VNIPSLVYFR 1608
            ...|:|:.||
Mouse   379 RGYPTLLLFR 388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)01289NP_001163065.1 PDI_a_family 50..145 CDD:239259
PDI_a_family 384..479 CDD:239259
Thioredoxin_6 510..689 CDD:404691
ER_PDI_fam 700..>916 CDD:273457
PDI_a_family 1129..1226 CDD:239259
TRX_family 1433..>1502 CDD:239245 17/81 (21%)
Txndc5NP_663342.3 PDI_a_ERp46 47..150 CDD:239303 25/112 (22%)
ER_PDI_fam 52..417 CDD:273457 69/358 (19%)
PDI_a_ERp46 176..276 CDD:239303 18/109 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..302 3/20 (15%)
PDI_a_ERp46 308..409 CDD:239303 18/82 (22%)
Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138 414..417
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0191
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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