DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hlk and PDIA6

DIOPT Version :10

Sequence 1:NP_001163065.1 Gene:hlk / 46017 FlyBaseID:FBgn0010482 Length:1786 Species:Drosophila melanogaster
Sequence 2:NP_001269633.1 Gene:PDIA6 / 10130 HGNCID:30168 Length:492 Species:Homo sapiens


Alignment Length:386 Identity:85/386 - (22%)
Similarity:141/386 - (36%) Gaps:83/386 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  1421 TEDRIELITRQMLETMVEETQYLAVYFYKINCNICDQIL----EGLELIDDECDVFGIHMVKIQD 1481
            ::|.|||........:::......|.||...|..|.::.    :....:.|...|..:...|  .
Human    76 SDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADK--H 138

  Fly  1482 PQLAKRYSIKTFPALVYF--RNGNPLLFEGDLQNEQ------SVLEWLIDD-------------- 1524
            ..|..:|.::.||.:..|  ....|..::|....|.      |.|..|:.|              
Human   139 HSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQ 203

  Fly  1525 ---DNRELADEIEEVNERMLDRLMAESTLLVVFFYDDDCAECEEILEELEEIDGEADMFGIDFVK 1586
               |:....|.||..::.....::....:.:|.||...|..|:.:..|......|........||
Human   204 GRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVK 268

  Fly  1587 IASIQA------AKKYEIVNIPSLVYFRK-QVPVLYDGDLHQHDKVITWLTSQDVF-------EI 1637
            :|::.|      |.:|.|...|::..|:| :.||.|||...:.|.|...|   |:|       |:
Human   269 LAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRAL---DLFSDNAPPPEL 330

  Fly  1638 KNEIEEVNRKMLDKLLEENEFLAVFFYEHNQPDSTAALEKLENIDSETDNLDITFVKMADSRYAK 1702
               :|.:|..:..:..||::...|....|.. |:.||        .....|:: .:|:||....|
Human   331 ---LEIINEDIAKRTCEEHQLCVVAVLPHIL-DTGAA--------GRNSYLEV-LLKLADKYKKK 382

  Fly  1703 KWG------------VTKL-------PAM--VYFRRRFPSIYRGDLLSEDEVLEWLRKNRF 1742
            .||            .|.|       |||  :..|:...::.:|. .||..:.|:||:..|
Human   383 MWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGS-FSEQGINEFLRELSF 442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hlkNP_001163065.1 PDI_a_family 50..145 CDD:239259
ER_PDI_fam 381..>670 CDD:273457
PDI_a_family 384..479 CDD:239259
ER_PDI_fam 700..>916 CDD:273457
PDI_a_family 1129..1226 CDD:239259
TRX_family 1433..>1502 CDD:239245 13/74 (18%)
PDIA6NP_001269633.1 PDI_a_P5 78..180 CDD:239299 20/103 (19%)
PDI_a_P5 213..318 CDD:239299 27/104 (26%)
P5_C 327..456 CDD:239281 30/130 (23%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.