DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and Igsf9

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	NP_001139272.1	Gene:	Igsf9 / 93842	MGIID:	2135283	Length:	1179	Species:	Mus musculus

Alignment Length:	1488	Identity:	386/1488 - (25%)
Similarity:	590/1488 - (39%)	Gaps:	401/1488 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 IQVLQFVLVSLLALLAKNAQAHNIPEDAVHITAILGEGVIFNCHVEFPNDHPVPYVLQWDKKVSE 172
            |..|:..::||  ::::.|.....|| .|.:....||..:..|.:..|..||..:|::|    ..
Mouse     2 IWCLRLTVLSL--IISQGADGRRKPE-VVSVVGRAGESAVLGCDLLPPAGHPPLHVIEW----LR 59

  Fly   173 TGSDLPIYIWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRESDQGWYECKVVFLNR-DP 236
            .|..|||:|.:..|...|:..|.|||...:      .|||.:..:|..|||||||:|:||:: .|
Mouse    60 FGFLLPIFIQFGLYSPRIDPDYVGRVRLQT------GASLQIEGLRVEDQGWYECRVLFLDQHSP 118

  Fly   237 KQ-HKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTPEILWYKDANPVDPSPTV 300
            :| ..||:|.||.|::||:|..||..::.|...:::.|.|.|.|:|.|.:.|......:......
Mouse   119 EQDFANGSWVHLTVNSPPQFQETPPLVLEVKELEAVTLRCVARGSPQPYVTWKFRGQDLGKGQGQ 183

  Fly   301 GIFNDGTELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVPPTNQTKLEGEKVIFS 365
            ....:|| |.|..:.....|:|||.|.:.||.::|..::::.|..||:|||:|.|....:.|..:
Mouse   184 VQVQNGT-LWIRRVERGSAGDYTCQASSSEGSITHATQLLVLGPPVIVVPPSNSTVNSSQDVSLA 247

  Fly   366 CEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQS 430
            |.|:|.|.|:|..|:::|..|..::.|::||.|..||||.:...:|||:|.|.|..:||...|.|
Mouse   248 CRAEAYPANLTYSWFQDGVNVFHISRLQSRVRILVDGSLWLQATQPDDAGHYTCVPSNGFLHPPS 312

  Fly   431 ASAYLSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTKDKRLLEPYQMKDIVVMAN 495
            |||||:|.|||:||..|....||..:.||::|.::::|.|.:||||||.:.|:..:.....:...
Mouse   313 ASAYLTVLYPAQVTVMPPETPLPTGMRGVIRCPVRANPPLLFVTWTKDGQALQLDKFPGWSLGPE 377

  Fly   496 GSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEPETLYQRKVGDSVEMHCDA 560
            |||:....||...|:|:|||||:.||||.|.|..||::.||||..:|:..|.::||..:.:.|
Mouse   378 GSLIIALGNENALGEYSCTPYNSLGTAGPSPVTQVLLKAPPAFIDQPKEEYFQEVGRELLIPC-- 440

  Fly   561 LEAEGTERPTIKWQR----QEGEQLTESQRNRIKISGGNITIENLRREDFGYYQCVVSNEVATLM 621
             .|.|...|.:.|.:    .:|:...:        |..::.:..|.:|..|.::|..||.||.:.
Mouse   441 -SARGDPPPIVSWAKVGRGLQGQAQVD--------SNNSLVLRPLTKEAQGRWECSASNAVARVT 496

  Fly   622 AVTQLVIEGTQPHAPYNITGKATESSITLQWLPGYSGGSEYKQDYTIWFR------EAGVNDWQT 680
            ..|.:.:.||.||...|::.........:.|.||:.||  |.|.:::|:.      :...:||.:
Mouse   497 TSTNVYVLGTSPHVVTNVSVVPLPKGANVSWEPGFDGG--YLQRFSVWYTPLAKRPDRAHHDWVS 559

  Fly   681 ISVTPSGSTQVTINGLASGTTYEFQVVGRNVLGDGMMSKVM--TVRTLEDAPAAPRNVKAATQPP 743
            ::| |.|:|.:.:.||.:...|:|.|:.:|.||.|..|:::  ....|...||||
Mouse   560 LAV-PIGATHLLVPGLQAHAQYQFSVLAQNKLGSGPFSEIVLSIPEGLPTTPAAP---------- 613

  Fly   744 DSFFQLMPDEADLLAYFDIYFHTDSRGTLVYSPPKLRVKGPKPGPPRNVSVTEVSNGFLITWQSP 808
                .|.|.|.                     ||.|       .|||.:.......|.|:.|..|
Mouse   614 ----GLPPTEI---------------------PPPL-------SPPRGLVAVRTPRGVLLHWDPP 646

  Fly   809 LERAHIVKFYTIKYRTDAQ-WKTLNRGQIRPEETQYLVKNLVGGRTYYFRVLANSEKSYESSD-- 870
            ......:..|.::.|..:| |:.|::| :...|.|.||..|:....|.||::|.:: ||.|..
Mouse   647 ELIPGRLDGYILEGRQGSQGWEILDQG-VAGTEIQLLVPGLIKDVLYEFRLVAFAD-SYVSDPSN 709

  Fly   871 ---------EVKFPVPARVK-----HKAITAGVVGGILFFIVAIILSVCAVKICNKRK-RRKQEK 920
                     ||   .|:|.:     .:.:.||||||:.|..||:::|:.|..:.|:|: .|:..|
Mouse   710 VANISTSGLEV---YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAACLMNRRRAARRHRK 771

  Fly   921 EFNMVACRITDARNIAANNHHLHNRSTGSISSGQVPLKKYKQTRISSLTAILIAILHWIW----- 980
            ........|...|..:.:     :.:.||.|...|...|.:.:.:.||...|      :|
Mouse   772 RLRQDPPLIFSPRGKSGS-----HSAPGSGSPDSVTKFKLQGSPVPSLRQSL------LWGEPAR 825

  Fly   981 PPDRCTNCHSIYSSPNLEDGDEDDGGGGRRRSVSRIQRSLDGRFVLDVEGVSKLGYSQQTLESGN 1045
            ||           ||:     .|...|.....:..|.|..|||||:.
Mouse   826 PP-----------SPH-----PDSPLGRGPLPLEPICRGPDGRFVMG------------------ 856

  Fly  1046 VDVVDGGLFERRNSNVSQKSSSDDGGFLSRRNFITARASWRRPLVASSSQLSLQSAADSARGFLQ 1110
                                                      |.||.|.:
Mouse   857 ------------------------------------------PTVAPSQE--------------- 864

  Fly  1111 GLLKIGAKQSAVPPNSQSYFDEAVSGARYQNVLRPYTSSNNLYGNADRSRPLHINTISGSLSQQQ 1175
               |:..::|                       .|.||:..|..:.|.|
Mouse   865 ---KLCLERS-----------------------EPRTSAKRLAQSFDCS---------------- 887

  Fly  1176 QLYTPSRISRIFSSSPQQLQPHHQQLLLSSGGSGA-YPTHFSDLSTVYPPNSAERSS-HNLSSRY 1238
                        ||||                ||. .|...:|:|.|..|.:|..|. .......
Mouse   888 ------------SSSP----------------SGVPQPLCITDISPVGQPLAAVPSPLPGPGPLL 924

  Fly  1239 RYYSQELPSLRTIQEETRRQQQQKQHPLEDHFVPLQLPSPPSWRSYYQSQ----ASYRPRTRWYP 1299
            :|.|  ||..|.:.             ::..:.||:.|:|.....:..||    :|:.|.....|
Mouse   925 QYLS--LPFFREMN-------------VDGDWPPLEEPTPAPPPDFMDSQPCPTSSFLPPPDSPP 974

  Fly  1300 RHHSRLFSNRQQQHEMLSPLPQLNL---NLRNSMNPGGLEASPES--RSSSSGFGSKNTSNHPGS 1359
            .:...:.........:.|..|...|   .||..:.||.|.|:|..  .|.|||.||.:.
Mouse   975 ANLRAVLPGTLMGVGVSSEPPYTALADWTLRERVLPGLLSAAPRGSLTSQSSGRGSASF------ 1033

  Fly  1360 TSEWRLLPPYRAP--------PSPPKHSGYFGGQQAQGQTPHGSYSYPRATTPPYTMAHWLEMIS 1416
                 |.||..||        |:|...|.:..|.:          .:||       ..|.:.:..
Mouse  1034 -----LRPPSTAPSAGGSYLSPAPGDTSSWASGPE----------RWPR-------REHVVTVSK 1076

  Fly  1417 RLNAATDSNLPKAPCPVDVGSVDGHYEFDPATP---------TPSASSMLREDLNLHIDTHPYHH 1472
            |.|.                |||.:||:|...|         .|..:|.         .|||...
Mouse  1077 RRNT----------------SVDENYEWDSEFPGDMELLETWHPGLASS---------RTHPELE 1116

  Fly  1473 HTLG---PLSGSLLHSHAPYGGGARKQRSLPAHLPRYDNVEVRLQAMREEFYAYRKRQ 1527
            ..||   |....||:               |.|..   ..|.|..|:||||.|:|:|:
Mouse  1117 PELGVKTPEESCLLN---------------PTHAA---GPEARCAALREEFLAFRRRR 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	40/114 (35%)
		IG_like	137..229	CDD:214653	30/91 (33%)
		I-set	253..341	CDD:254352	24/87 (28%)
		IGc2	268..331	CDD:197706	16/62 (26%)
		I-set	346..437	CDD:254352	40/90 (44%)
		Ig	349..437	CDD:299845	38/87 (44%)
		Ig	459..530	CDD:299845	29/70 (41%)
		IG_like	549..628	CDD:214653	18/82 (22%)
		IGc2	551..617	CDD:197706	14/69 (20%)
		FN3	633..725	CDD:238020	27/99 (27%)
		FN3	786..874	CDD:238020	27/99 (27%)
Igsf9	NP_001139272.1	IG_like	28..110	CDD:214653	30/91 (33%)
		Ig	136..223	CDD:386229	24/87 (28%)
		Ig_3	227..305	CDD:372822	31/77 (40%)
		Ig	341..404	CDD:386229	24/62 (39%)
		Ig	436..500	CDD:319273	15/74 (20%)
		FN3	508..599	CDD:238020	27/93 (29%)
		FN3	625..715	CDD:238020	25/91 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..807		9/44 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..842		7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..974		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079		20/90 (22%)
		PDZ-binding	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7355
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002337
OrthoInspector	1	1.000	-	-		otm42832
orthoMCL	1	0.900	-	-		OOG6_104975
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4797
SonicParanoid	1	1.000	-	-		X1123
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.750