DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and MYPN

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	XP_016872322.1	Gene:	MYPN / 84665	HGNCID:	23246	Length:	1346	Species:	Homo sapiens

Alignment Length:	1400	Identity:	248/1400 - (17%)
Similarity:	402/1400 - (28%)	Gaps:	580/1400 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 PKQHKNGTWFHLDVHAPPRFS------VTPEDIIYVNLGDSIILNCQADGTPTPEILWYKDANPV 294
            |....:..::...:..||||:      ..||       |..:.|:|...|.|.|::.||.:...:
Human   278 PGSSPSSLYYEEPLGQPPRFTQKLRSREVPE-------GTRVQLDCIVVGIPPPQVRWYCEGKEL 335

  Fly   295 DPSPTVGIFNDGT--ELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVPPTNQTKL 357
            :.||.:.|...|.  .|.|:....||.|.|:|.|.|..|..|.:|.:.|.|
Human   336 ENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG-------------- 386

  Fly   358 EGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIINPI-KPDDSGQYLCEV 421
                 :.|.::             ||.|.:|.                :|.| ||
Human   387 -----VSSSDS-------------EGDPNKEE----------------MNRIQKP---------- 407

  Fly   422 TNGIGDPQSASAYLSVEYPAKVTFTPTVQYL---PFRLAGVVQCYIKSSPQLQYVTWTKDKRLLE 483
             |.:..|.:.||.:.   ||    .|..|:|   | |:|.:.||   .||
Human   408 -NEVSSPPTTSAVIP---PA----VPQAQHLVAQP-RVATIQQC---QSP--------------- 445

  Fly   484 PYQMKDIVVMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKP----PAFTVEPET 544
                                          |.| .||..|          ||    |.||...:.
Human   446 ------------------------------TNY-LQGLDG----------KPIIAAPVFTKMLQN 469

  Fly   545 LYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRI------------KISGGNIT 597
            | ....|..|...|   ..:|...|.::|.| ||..:.:|...||            :|.  .:.
Human   470 L-SASEGQLVVFEC---RVKGAPSPKVEWYR-EGTLIEDSPDFRILQKKPRSMAEPEEIC--TLV 527

  Fly   598 IENLRREDFGYYQCVVSNEVATLMAVTQLVIEGT-----------------------QPHAPY-- 637
            |..:..||.|.:.|..||:..|:.::.||.:.|.                       ||..|:
Human   528 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSE 592

  Fly   638 -----------------NITGKATESSITLQW---LPGYSGGSEYKQDYTIWFREAGVNDWQTIS 682
                             |.....:.|.|.|:.   ||....|||...       ||||   .|..
Human   593 PPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASS-------EAGV---VTTR 647

  Fly   683 VTPSGSTQVTINGLASGT--------------------TYEFQVVGRNVLGDGMMSK-------- 719
            .|...|.|...||.|:.|                    :.:.|.:...||.:....:
Human   648 QTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPK 712

  Fly   720 ----VMTVRTLEDAPAAPRNVKAATQPPDSFFQLMPDEADLLAYFDIYF---------------- 764
                .|||......||...:.|....|....|.|...:         ||
Human   713 EFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPK---------YFFPSTNTTAATVAPSSS 768

  Fly   765 -------------HTDSRGTLVYSPPKLRVKGP----------KPGP------------------ 788
                         .|.|:.:|:.|.|.::.|.|          .|||
Human   769 PVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGNQF 833

  Fly   789 -PRNVSVTEVSNGFLITWQSPL----------------------ERAHIVKFYTIKYRTDAQWKT 830
             ||.||...||....|  |:|:                      ..|..:....:..:.....:.
Human   834 QPRCVSPIPVSPTSRI--QNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKSPQP 896

  Fly   831 LNRGQIRPEETQYLVKNLVGGRTYYFRVLANSEK----SYES--SDEVKF-----PVPA---RVK 881
            :|...||  ||:..|...:|.:..:..|..|.::    |:|.  .:|::|     ||..   .::
Human   897 VNDDNIR--ETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQ 959

  Fly   882 HKAITAGVVGGILFFIVAIILSVCAVKICNKRKRRKQEKEFNMV--ACRITDARNIAANNHHLHN 944
            |..|..|               .|...|.:||.:..:..|.:.|  .|:|..
Human   960 HDEIPTG---------------KCIAPIFDKRLKHFRVTEGSPVTFTCKIVG------------- 996

  Fly   945 RSTGSISSGQVPLKKYKQTRISSLTAILIAILHWIWPPDRCTNCHSIYSSPNLEDGDEDDGGGGR 1009
                      :|:.|                ::|                  .:||.:.    .:
Human   997 ----------IPVPK----------------VYW------------------FKDGKQI----SK 1013

  Fly  1010 RRSVSRIQRSLDGRFVLDVEGVSKLGYSQQTLESGNVDVVDGGLFERRNSNVSQKSSSDDGGFLS 1074
            |....:::|..||...|.:|..                                 :|.|||.:
Human  1014 RNEHCKMRREGDGTCSLHIEST---------------------------------TSDDDGNY-- 1043

  Fly  1075 RRNFITARASWRRPLVASSSQLSLQ---------SAADSARGFLQGLLKIGAKQSAVPPNSQSYF 1130
                 |..|:..:..::.|..|.:|         ||..|.||      :...::....|..:.:|
Human  1044 -----TIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRG------RSRVQERDKEPLQERFF 1097

  Fly  1131 DEAVSGARYQNVLRPY--TSSNNLYGNADRSRPLHINTISGSLSQQQQLYTPSRISRIFSSSPQQ 1193
                         ||:  .:..::..:..|...|... :||        ..|..::.:.:..|..
Human  1098 -------------RPHFLQAPGDMVAHEGRLCRLDCK-VSG--------LPPPELTWLLNGQPVL 1140

  Fly  1194 LQPHHQQLLLSSGGSGAY--PTHFSDLSTVYPPNSAERSSHNLSSRYRYYSQELPSLRTIQEETR 1256
            ....|:.|:..:|.....  |....|..|.....:.:...::.|......::|:.....|.|:.:
Human  1141 PDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQ 1205

  Fly  1257 RQQQQKQHPLEDHFVPLQLPSPPSWRSYYQSQASYRPRTRWYPRHHSRLFSNRQQQHE------- 1314
            .....:.||:......:.:| ||.:  |::......|.||           .|...|:
Human  1206 NCGVPEGHPVRLECRVIGMP-PPVF--YWKKDNETIPCTR-----------ERISMHQDTTGYAC 1256

  Fly  1315 -MLSPLPQLNLNLRNSMNPGGLEASPESRSSSSGFGSKNTSNHPGSTS---------EW--RLLP 1367
             ::.|                      ::.|.:|:.:.:..|..|..|         :|  ::.|
Human  1257 LLIQP----------------------AKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPP 1299

  Fly  1368 PYRAPPSPPKHSGYFGGQQAQGQTPHGSYSYPRAT 1402
            |....||..:    :|...::|.....::|...:|
Human  1300 PMSVRPSGSR----YGSLTSKGLDIFSAFSSMEST 1330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	1/13 (8%)
		IG_like	137..229	CDD:214653
		I-set	253..341	CDD:254352	29/95 (31%)
		IGc2	268..331	CDD:197706	21/64 (33%)
		I-set	346..437	CDD:254352	13/91 (14%)
		Ig	349..437	CDD:299845	13/88 (15%)
		Ig	459..530	CDD:299845	9/70 (13%)
		IG_like	549..628	CDD:214653	23/90 (26%)
		IGc2	551..617	CDD:197706	20/77 (26%)
		FN3	633..725	CDD:238020	29/145 (20%)
		FN3	786..874	CDD:238020	25/134 (19%)
MYPN	XP_016872322.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910