DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tutl and Mdga1

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	NP_001355352.1	Gene:	Mdga1 / 74762	MGIID:	1922012	Length:	956	Species:	Mus musculus

Alignment Length:	857	Identity:	190/857 - (22%)
Similarity:	304/857 - (35%)	Gaps:	188/857 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 TLTASPA-----KTAAFTVKTTRRRRSRRRAEGSSICVPIRRGQGSTPTPTIQVLQFVLVSLLAL 121
            |.||..|     :|:.|. :|.|..|..|...|...|    :.:.....|.|:.::.
Mouse    73 TKTAGSASDKFQETSVFN-ETLRIERIARTQGGRYYC----KAENGVGVPAIKSIRV-------- 124

  Fly   122 LAKNAQAHNIPEDAVHITAILGEG-------VIFNCHVEFPNDHPVPYVLQWDKKVSET------ 173
               :.|..:.|...||.|.....|       |...|.|.  ::.|..::  | |:.|:|
Mouse   125 ---DVQYLDEPVLTVHQTVSDVRGNFYQEKTVFLRCTVS--SNPPARFI--W-KRGSDTLSHSQD 181

  Fly   174 -GSDL--PIYIWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRESDQGWYECKVVFLNRD 235
             |.|:  |:|...|                        :..|.|.|:|..|...|.|:|...|..
Mouse   182 NGVDIYEPLYTQGE------------------------TKVLKLKNLRPQDYASYTCQVSVRNVC 222

  Fly   236 PKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNC-QADGTPTPEILWYKDANPVDPSPT 299
            ....|..|:...:..|||...::..:.:.||.|:::.:.| ...|.|.|::.|.....|:    .
Mouse   223 GIPDKAITFQLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLHWSHGPGPL----P 283

  Fly   300 VGIFNDGTELRISTIRHEDIGEYTCIARNGEGQ-VSHTARVIIAG--GAVIMVPPTNQTKLE--- 358
            :|....|..|.|.:::..|.|.|.|.|.|..|. ...|..:::..  .|...:.|....:.|
Mouse   284 LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSLKNATFQITPDMIKESENIQ 348

  Fly   359 -GEKVIFSCEAKAMP-GNVTVRWYREGSPVREVAALETRVTIRKD-------GSLIINPIKPDDS 414
             |:.:..||...|:| ..|..:|::.|.|.|....|   :..|.|       .||.:..:...|.
Mouse   349 LGQDLKLSCHVDAVPQEKVNYQWFKNGKPARTSKRL---LVTRNDPELPAVTSSLELIDLHFSDY 410

  Fly   415 GQYLCEVTNGIGDPQSASAYLSVEYP-AKVTFTPTVQYLPFRLAGVV--------QCYIKSSPQL 470
            |.|||..:    .|.|....||:|.. :..|..||:.....|....|        ||.::..|:
Mouse   411 GTYLCMAS----FPGSPVPDLSIEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPR- 470

  Fly   471 QYVTWTK-DKR-LLEPYQMKDIVVMANGSLLFTRVNEEHQGQYAC--TPYNAQGTAGASGVMDVL 531
            ..|.|:: ||. .|.|..:. :....:|.|....|:.:..|.|.|  ..||..........:.:.
Mouse   471 PPVLWSRVDKEAALLPSGLA-LEETPDGKLRLESVSRDMSGTYRCQTARYNGFNVRPREAQVQLT 534

  Fly   532 VRKPPAFTVEPETLYQRK-VGDSVEMHCDALEAEGTERPTIKWQRQEGEQL----------TESQ 585
            |..||  .|||.:...|: :|..|.:.|..|........:..| |.:|:.|          .|:.
Mouse   535 VHFPP--EVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW-RFKGQLLPPPPVLPAAAVETP 596

  Fly   586 RNRIKISGGNITIENLRREDFGYYQCVVSNEVATLMAVTQLVIEGTQPHAPYNITGKATES---- 646
            .:      ..:.::.|.|:..|.|:|.|||:|.:...:.|:..:...|.. |..|...|.|
Mouse   597 DH------AELRLDALTRDSSGNYECSVSNDVGSATCLFQVSAKAYSPEF-YFDTPNPTRSHKLS 654

  Fly   647 ---SITLQWLPGYSGGSEYKQDYTIWFRE-----AGVNDWQTISVTPSGSTQVTINGLASGTTYE 703
               |..|||........:...:|.:..|:     |.|.......|......:..:..|....:||
Mouse   655 KNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAMVKAIPVRRVEKGQLLEYILTDLRVPHSYE 719

  Fly   704 FQVVGRNVLGDG-MMSKVMTVRTLEDAPAAPRNVKAATQPPDSFFQLMPDEADLLAYF------- 760
            .::......|.| |.|:::..                |:|.:     :|..:|...:|
Mouse   720 IRLTPYTTFGAGDMASRIIHY----------------TEPIN-----LPSLSDNTCHFEDEKICG 763

  Fly   761 ---DIYFHTD-SRGTLVYSPPKLRVKGPKPGPPRNVSVTEVSNGFLITWQSPLE---RAHIV--- 815
               |:..:.| :|...:...||   :.|..|||.::|.|.......|....|.|   ||.:|
Mouse   764 YTQDLTDNFDWTRQNALTQNPK---RSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPL 825

  Fly   816 -----KFYTIKY 822
                 |||.:.:
Mouse   826 YNASAKFYCVSF 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	27/128 (21%)
		IG_like	137..229	CDD:214653	23/107 (21%)
		I-set	253..341	CDD:254352	22/89 (25%)
		IGc2	268..331	CDD:197706	17/63 (27%)
		I-set	346..437	CDD:254352	25/102 (25%)
		Ig	349..437	CDD:299845	25/99 (25%)
		Ig	459..530	CDD:299845	18/82 (22%)
		IG_like	549..628	CDD:214653	19/89 (21%)
		IGc2	551..617	CDD:197706	17/75 (23%)
		FN3	633..725	CDD:238020	21/104 (20%)
		FN3	786..874	CDD:238020	14/48 (29%)
Mdga1	NP_001355352.1	Ig	56..115	CDD:353325	12/46 (26%)
		IG	152..217	CDD:214652	20/93 (22%)
		IG	248..326	CDD:214652	21/81 (26%)
		I-set	333..418	CDD:336764	22/87 (25%)
		IG	450..535	CDD:214652	18/86 (21%)
		Ig_3	538..620	CDD:339005	21/90 (23%)
		MAM	754..918	CDD:334181	21/87 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	780..799		7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000