DRSC/TRiP Functional Genomics Resources

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Protein Alignment tutl and USH2A

DIOPT Version :9

Sequence 1:NP_001303307.1 Gene:tutl / 46015 FlyBaseID:FBgn0010473 Length:1536 Species:Drosophila melanogaster
Sequence 2:NP_996816.3 Gene:USH2A / 7399 HGNCID:12601 Length:5202 Species:Homo sapiens


Alignment Length:1780 Identity:337/1780 - (18%)
Similarity:536/1780 - (30%) Gaps:599/1780 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 CRALSTQHNTEKSKEQQQQSQPLEIPEQRASKCRGDIDRTTTTTIPASKT----LTASPAK---- 69
            |.|.|.:     ||...:::.|:.:      ||      ..|..||.|:.    :..:|.|    
Human  3337 CSASSGE-----SKAHIKKNDPVPV------KC------CETELIPKSQKCCNGVGYNPLKYVCS 3384

  Fly    70 ---TAAFTVKTTRRRR-----SRRRAE---------GSSICVPIRRGQGSTPTPTI--------Q 109
               :....:|.|:..|     |....|         .|.||..||....||...:|        :
Human  3385 DKISTGMMMKETKECRILCPASMEATEHCGRCDFNFTSHICTVIRGSHNSTGKASIEEMCSSAEE 3449

  Fly   110 VLQFVLVSLLALLAKNAQAHNIPEDAVHITAILGEGVIFNCHVEFPNDHPV-------------- 160
            .:....|:..:....|.:.:...|..:......|.|:..........|.|.              
Human  3450 TIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLE 3514

  Fly   161 -PYVLQWDKKVSETGSDLPIYIWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRESDQGW 224
             ..||.|.|.:...|   || |:|......||.              |...||:.:: :|..|.:
Human  3515 DTIVLNWRKPIQSNG---PI-IYYILLRNGIER--------------FRGTSLSFSD-KEGIQPF 3560

  Fly   225 YE-------CKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPT 282
            .|       |.|.......|.....|....:...||  |:|....:.::|..|:           
Human  3561 QEYSYQLKACTVAGCATSSKVVAATTQGVPESILPP--SITALSAVALHLSWSV----------- 3612

  Fly   283 PEILWYKDANPVDPS---PTVG---IFNDGTELRISTIRHEDIGEYTCIARNGEGQVSHTARVII 341
            ||     .:|.|...   ..||   |..|.|:.|..|:  ..:..||        ..|.|.....
Human  3613 PE-----KSNGVIKEYQIRQVGKGLIHTDTTDRRQHTV--TGLQPYT--------NYSFTLTACT 3662

  Fly   342 AGGAVIMVPPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLII 406
            :.|.....|...||.....:.::......:..:.||..|  .|...:...|.::..:.::|:|:.
Human  3663 SAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVELY--WSLPEKPNGLVSQYQLSRNGNLLF 3725

  Fly   407 -----------NPIKPDDSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVV 460
                       ..::|:....|..||..|.|  .|||....|:.|..   ||...|.|:.:..: 
Human  3726 LGGSEEQNFTDKNLEPNSRYTYKLEVKTGGG--SSASDDYIVQTPMS---TPEEIYPPYNITVI- 3784

  Fly   461 QCYIKSSPQLQYVTWTKDKRLLEPYQMKDIVVMANGS---LLFTRVNEEHQGQYACTPYN----- 517
                  .|...:|.|.....|:....::..|::.:||   |.|:..:.:.......||:.     
Human  3785 ------GPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIR 3843

  Fly   518 ----AQGTAGASGVMDVLVRKPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQR--- 575
                ..|:.|.|..|         |...||..       .::::...|:|.|:....|||..   
Human  3844 IQACQNGSCGVSSRM---------FVKTPEAA-------PMDLNSPVLKALGSACIEIKWMPPEK 3892

  Fly   576 -----------------QEGEQLTESQRNRIKISGGNITIENLRREDFGYYQCVVSNEVATLMAV 623
                             :|...|.......::......|:......::....|.....|.:|.::
Human  3893 PNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSL 3957

  Fly   624 TQLVIEGTQPH-APYNITGKATES-SITLQWL-PGYSGG--SEYKQDYTIWFREAGVNDWQTISV 683
            ||.:....|.. ||:   .:||.: |:.|.|. |....|  |.|:..|.....:...|.....:.
Human  3958 TQTLEAPPQDFPAPW---AQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAF 4019

  Fly   684 TPSG-STQVTINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAAPRN------------ 735
            |..| |.|..:.||...|||...||..|..|: ::|....::|||.:|:..||            
Human  4020 TVKGTSHQAHLYGLEPFTTYRIGVVAANHAGE-ILSPWTLIQTLESSPSGLRNFIVEQKENGRAL 4083

  Fly   736 -------------VKAATQPPDSFF-------QLMPDEADLLAYFDIYFHTDSRGTLVYSPPKLR 780
                         :|......|.|.       |.:....|....:.:.....:|....:|     
Human  4084 LLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHS----- 4143

  Fly   781 VKGPKP-----GPP--------RNVSVTEVSNGFLITWQSPLE-RAHIVKFYTIK---------- 821
              .|:|     .||        .:|..|.|.    ::|..|:. ...|:::..|:          
Human  4144 --APQPLWTDEAPPDSQLAPTVHSVKSTSVE----LSWSEPVNPNGKIIRYEVIRRCFEGKAWGN 4202

  Fly   822 -------------YRTDAQWKTLNRGQIRP-EETQYLVK--NLVGGRTYYFRVLANSEK------ 864
                         |.|:......|...::| .:.:|.:.  |..|.....:.|:...:.      
Human  4203 QTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLS 4267

  Fly   865 ----SYESSDEVKFPVPARVKHKAITAGVVGGILFFIVAIILSVCAVKICNKRKRRKQEKE---- 921
                ||.|.:      |.::....|......||:                  :..|.|..|    
Human  4268 PPVISYVSMN------PQKLLISWIPPEQSNGII------------------QSYRLQRNEMLYP 4308

  Fly   922 --FNMVACRITDARNI--AANNHHLHNRSTGSISSGQVPLKKYKQTRISSLTAILIAILHWIWPP 982
              |:.|....||...:  :..::.|...::|..|:.       |.|.|::|.|....:.    ||
Human  4309 FSFDPVTFNYTDEELLPFSTYSYALQACTSGGCSTS-------KPTSITTLEAAPSEVS----PP 4362

  Fly   983 D----RCTNCHSIYSSPNLEDG-----------DEDDGGGGRRRSVSRIQRSLDGRFVL------ 1026
            |    ..|..:..:|.|.:::|           .|...|.|....||.:|......|.|      
Human  4363 DLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNG 4427

  Fly  1027 -DVEGVSKLGYSQQTL----ESGNVDVVDGGLFE-----RRNSNVSQKSSS--DDG-----GFLS 1074
             ....|||..::.:.|    :|..:.|......|     .||.|...:|..  .||     |..:
Human  4428 GCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLET 4492

  Fly  1075 R-RNF-ITARASWRRPLVASSSQLSLQSAADSARGFLQGLLKIGAKQSA----VPPNSQSYFDEA 1133
            | |:| :|....:...:.||:||          .|.|..|:|.....||    .||..|:...:.
Human  4493 RYRDFTLTPGVEYSYTVTASNSQ----------GGILSPLVKDRTSPSAPSGMEPPKLQARGPQE 4547

  Fly  1134 V-----SGARYQNVLRPYT-----------------SSNNLYGN----ADRSRPLH--------I 1164
            :     ...|....:..||                 :::|.:|.    .::.:|.|        .
Human  4548 ILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQAC 4612

  Fly  1165 NTISGSLSQQQQLYTPSRISRIFSSSPQ--------------------QLQPHHQQL-------- 1201
            .|:..:.|....:.|| .|:.:....|.                    .|||:.:.|        
Human  4613 TTLGCASSDWTFIQTP-EIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQ 4676

  Fly  1202 -----------LLSSGGSGAYPTHFSDLS----TVY-------------------------PPN- 1225
                       |:.:|.|    |.|.|..    |.|                         ||. 
Human  4677 IATQPRKSNPVLIYNGSS----TSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEG 4737

  Fly  1226 ------------------SAERSSHNLSSRYRYYSQELPSLRTIQEETRRQQQQKQHPLE---DH 1269
                              ||....:.:.|.||.:|.......|:..| ....||..|.|:   ::
Human  4738 LRAPTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSE-GMATQQTLHGLQAFTNY 4801

  Fly  1270 FVPLQL------------------PSPPSWRSYYQ--SQASYRPRTRWYPRHHSRLFSN------ 1308
            .:.::.                  |:|||..|..|  :.||.....||.|    .:|.|      
Human  4802 SIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSP----PMFPNGVIHSY 4862

  Fly  1309 RQQQHEMLSP---LPQLNLNLRNSMNPGGLEASPESRSSSSGFGSKNT----------------S 1354
            ..|.|....|   ||         ..|..:|      :..:|.|.|.:                .
Human  4863 ELQFHVACPPDSALP---------CTPSQIE------TKYTGLGQKASLGGLQPYTTYKLRVVAH 4912

  Fly  1355 NHPGST-SEW------RLLPPYRAP 1372
            |..||| |||      :.||.||||
Human  4913 NEVGSTASEWISFTTQKELPQYRAP 4937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tutlNP_001303307.1 V-set 137..250 CDD:284989 25/134 (19%)
IG_like 137..229 CDD:214653 22/113 (19%)
I-set 253..341 CDD:254352 20/93 (22%)
IGc2 268..331 CDD:197706 14/68 (21%)
I-set 346..437 CDD:254352 19/101 (19%)
Ig 349..437 CDD:299845 19/98 (19%)
Ig 459..530 CDD:299845 15/82 (18%)
IG_like 549..628 CDD:214653 14/98 (14%)
IGc2 551..617 CDD:197706 10/85 (12%)
FN3 633..725 CDD:238020 27/97 (28%)
FN3 786..874 CDD:238020 21/137 (15%)
USH2ANP_996816.3 LamGL 146..283 CDD:214722
Laminin_N 291..516 CDD:413488
EGF_Lam 517..565 CDD:238012
EGF_Lam 574..639 CDD:238012
Laminin_EGF 641..691 CDD:395007
EGF_Lam 694..733 CDD:214543
Laminin_EGF 747..795 CDD:395007
EGF_Lam 794..844 CDD:238012
EGF_Lam 847..897 CDD:214543
EGF_Lam 900..948 CDD:238012
EGF_Lam 950..1000 CDD:238012
EGF_Lam 1001..>1037 CDD:238012
fn3 1058..1132 CDD:394996
fn3 1150..1227 CDD:394996
FN3 1242..1357 CDD:238020
FN3 1368..1451 CDD:214495
LamG 1519..1678 CDD:238058
LamG 1716..1868 CDD:238058
FN3 1956..2051 CDD:238020
FN3 2241..2313 CDD:238020
FN3 2329..2428 CDD:238020
FN3 2432..2528 CDD:238020
FN3 2533..2619 CDD:238020
FN3 2621..2719 CDD:238020
FN3 2724..2799 CDD:238020
FN3 2818..2920 CDD:238020
FN3 2925..3015 CDD:238020
FN3 3026..>3087 CDD:238020
FN3 <3449..3494 CDD:238020 5/44 (11%)
FN3 3503..3586 CDD:238020 20/101 (20%)
FN3 3590..3676 CDD:238020 23/113 (20%)
FN3 3680..3767 CDD:238020 17/90 (19%)
fn3 3777..3856 CDD:394996 14/85 (16%)
FN3 3866..3960 CDD:238020 13/100 (13%)
FN3 3964..4057 CDD:238020 28/96 (29%)
fn3 4161..4247 CDD:394996 13/89 (15%)
FN3 4268..4351 CDD:238020 20/113 (18%)
fn3 4357..4428 CDD:394996 15/74 (20%)
FN3 4444..4516 CDD:238020 18/81 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4518..4541 7/22 (32%)
FN3 4529..4627 CDD:238020 14/97 (14%)
FN3 4636..4730 CDD:238020 13/97 (13%)
FN3 4826..4927 CDD:238020 30/119 (25%)
PDZ-binding 5200..5202
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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