DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tutl and DSCAML1

DIOPT Version :9

Sequence 1:NP_001303307.1 Gene:tutl / 46015 FlyBaseID:FBgn0010473 Length:1536 Species:Drosophila melanogaster
Sequence 2:XP_011541219.1 Gene:DSCAML1 / 57453 HGNCID:14656 Length:2065 Species:Homo sapiens


Alignment Length:1929 Identity:376/1929 - (19%)
Similarity:604/1929 - (31%) Gaps:717/1929 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 LAKNAQAHNIPEDAVHITAIL----------GEGVIFNCHVE-FP--------NDHPVPYVLQWD 167
            ||:.|....:|:.|..|..||          |..|...|... :|        :..|:|...:|.
Human   221 LARAADPLCLPDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWT 285

  Fly   168 KKVSE-TGSDL-----------------------------PIYIWYESYPEHIEEGYKGRV--SR 200
            |:::. |.|||                             |:::...  |:.::.|....|  |.
Human   286 KRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLT--PKKLKTGIGSTVILSC 348

  Fly   201 VSQDSP-----------------------FGSASLNLTNIRESDQGWYECKVVFLNRDPKQHKNG 242
            ....||                       ..:.:|.:|:.::|..|.|:|   |..|..:..::.
Human   349 ALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQC---FATRKAQTAQDF 410

  Fly   243 TWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTPEILWYKDANPV--DPSPTVGIF-- 303
            ....|:...|...|...|.:  ||.|:...|.|.|.|.|.|.:.|..|..|:  |.|.....:  
Human   411 AIIALEDGTPRIVSSFSEKV--VNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTM 473

  Fly   304 NDGTELRISTIRH--------EDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVPPT-----NQT 355
            :|||     ||.|        .|.|.|.|.|||..|...:.||:.:.|      ||:     |.|
Human   474 SDGT-----TISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG------PPSIRAMRNIT 527

  Fly   356 KLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIINPI-KPDDSGQYLC 419
            .:.|...:.:|.....| ..:::||::...:.:    ..|..:.::|:|.:..: |..|.|:|||
Human   528 AVAGRDTLINCRVIGYP-YYSIKWYKDALLLPD----NHRQVVFENGTLKLTDVQKGMDEGEYLC 587

  Fly   420 EVTNGIGDPQ---SASAYLSVEYPAKVTFTPTVQYLPFRLAGV-----VQCYIKSSPQLQYVTWT 476
            .|   :..||   |.|.:::|:.|      |.:|...|..|.:     :.|.:.|......:||.
Human   588 SV---LIQPQLSISQSVHVAVKVP------PLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWR 643

  Fly   477 KDKRLLEPYQMKDIVVMANG----------SLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVL 531
            ||.:         :::..:|          ||..:.|:.:|.|.|.|...||..|  .|....::
Human   644 KDGQ---------VIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAAT--VSRERQLI 697

  Fly   532 VRKPPAFTVEP---ETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRIKISG 593
            ||.||.|.|:|   :.:|    |.:..::|   ..:|...|.:.|:..:|.. ...|.:.:.::|
Human   698 VRVPPRFVVQPNNQDGIY----GKAGVLNC---SVDGYPPPKVMWKHAKGSG-NPQQYHPVPLTG 754

  Fly   594 -------GNITIENLRREDFGYYQCVVSNEVAT------LMAVTQLVIEGTQPHAPYNITGKATE 645
                   .::.|.::..||.|||.|..||.|.|      .:.|....:..:.|:....|.|.|.|
Human   755 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKE 819

  Fly   646 ----------------------------------------------------------------- 645
                                                                             
Human   820 LNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINS 884

  Fly   646 ----------------------------SSITLQWLPGYSGGS-------EYKQDYTIW------ 669
                                        .|:.|:|...:.|.|       |||.....|      
Human   885 YGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQST 949

  Fly   670 ------FREAGVNDWQTISV---------------------------TPSG-------------S 688
                  ..:|.:.|....||                           .|.|             |
Human   950 RNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQS 1014

  Fly   689 TQVT--------INGL-----------ASGTTYEFQVVGRNVLGD-------------------- 714
            .|||        .||:           :.|:..::.:|.....||                    
Human  1015 IQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQ 1079

  Fly   715 -------GMMSKVMTVRTLEDAPA-APRNVKAA-----------TQPPDS------------FFQ 748
                   |..|..:...||||.|: .|.||:|.           ::||.|            |:.
Human  1080 AFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWS 1144

  Fly   749 LMPD---------------------------EADLLAYFDIYFHTDS----RGTLVYSPPKLRVK 782
            |..|                           ...:|||      |.:    |.:::|    ::.|
Human  1145 LYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAY------TQAGDGVRSSVLY----IQTK 1199

  Fly   783 GPKPGPPRNV-SVTEVSNGFLITWQSPLERAHIVKFYTI-------------KYRTDAQWKTLNR 833
            ...||||..: :|...::..:::|..|.:...:::.|||             :|.|.        
Human  1200 EDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETS-------- 1256

  Fly   834 GQIRPEETQYLVKNLVGGRTYYFRVLA-NSEKSYESSDEVKFPVPARVKHKAITAGVVGGILFFI 897
                ||:..|.:.:|..|:.|...|.| .|.....||::|......:...|.|:.|  |.:....
Human  1257 ----PEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFG--GTVTTPW 1315

  Fly   898 VAIILSVCAVKICNKRKRRKQEKEFNMVACRIT-DARNIAANNHHLHNRSTGSISSGQVPLKKYK 961
            :..:...|. .:.:.....|..|:....|..:: |...:...|..|..|:..:..||....   .
Human  1316 MKDVRLPCN-SVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTC---T 1376

  Fly   962 QTRISSLTAILIAILHWIWPPD--RCTNCHSIYSSPNLEDGDEDDGGGGRRRSVSRIQRSLDGR- 1023
            .|.......|::.:|..: |||  |.|...:..||..|.....|:||...|..|  :|.|:|.. 
Human  1377 ATNTGGFDTIIVNLLVQV-PPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFV--LQYSVDNSE 1438

  Fly  1024 -----FVLDVEGVSKLG------------YSQQTLESGNV-DVVDGGLFERRNSNVSQKSSSDDG 1070
                 |:...|...||.            .::.::.||.: ::::.....|      :.|.|.|.
Human  1439 EWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGR------EPSFSKDQ 1497

  Fly  1071 GFLSRRNFITARAS---WRR---PLVASSSQLSLQS--------AADSARGFLQGL-------LK 1114
            ...:..|...||.:   |..   |:.|...:...:.        |..|...||..|       |:
Human  1498 HLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEVFLTELREATWYELR 1562

  Fly  1115 IGAKQSA------------------VPP--NSQSYFDE-------------AVSGARYQNVLRP- 1145
            :.|..||                  :||  ::|...|:             |..|.....::|. 
Human  1563 MRACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFIVRKK 1627

  Fly  1146 -------------------YTSSNNLYGNADRSRP----LHINTISGSLSQQ-----QQL----- 1177
                               .:.:|..:....:..|    |||:.....|..:     :||     
Human  1628 RKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQLGDDKA 1692

  Fly  1178 ---YTPSRISRIFSSSPQQ----LQPHHQQLLLSSGGSGAYPTHFSDLSTVYP---PNSAE--RS 1230
               .|.:..|:  :.:||.    :..||..|:.|:|       ...|:|.:.|   |.|.:  :|
Human  1693 TIPVTDAEFSQ--AVNPQSFCTGVSLHHPTLIQSTG-------PLIDMSDIRPGTNPVSRKNVKS 1748

  Fly  1231 SHNLSSRYRYYSQ--------ELPSLRTIQEETRRQQQQKQHPL-----EDHFVPLQLPSPPSWR 1282
            :|  |:|.||.||        ..|: ||:..:.|  ....||.:     :.:...|...:.....
Human  1749 AH--STRNRYSSQWTLTKCQASTPA-RTLTSDWR--TVGSQHGVTVTESDSYSASLSQDTDKGRN 1808

  Fly  1283 SYYQSQ---ASYRPRTRWYPRHHSRLFSNRQQQHEMLSPLPQLNLNLRNSMNPGGLEASPESRSS 1344
            |...::   ::|....|.|  .|::|  ..|.||...........:..:.....|...:.:|.:|
Human  1809 SMVSTESASSTYEELARAY--EHAKL--EEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTS 1869

  Fly  1345 SSGFGSKNTSNHPGSTSEWRLLPPYRAPPSPPKHSGYFGGQQAQGQTPHGSYSYPRATTPPYTMA 1409
            .|      |.:.||..         |...||||......|:......||                
Human  1870 MS------TPSEPGIC---------RFTASPPKPQDADRGKNVAVPIPH---------------- 1903

  Fly  1410 HWLEMISRLNAATDSNLP--------------KAPCPVDVGSVDGHYEFDPATPTPSASSMLRED 1460
                   |.|.:...|||              :.||||                .|...:.:|  
Human  1904 -------RANKSDYCNLPLYAKSEAFFRKADGREPCPV----------------VPPREASIR-- 1943

  Fly  1461 LNLHIDTHPYH----HHTLGPLSGSLLHSHAPYGGGARKQRSLP 1500
             ||   ...||    |.||.|.|.||...| |....|....:||
Human  1944 -NL---ARTYHTQARHLTLDPASKSLGLPH-PGAPAAASTATLP 1982

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tutlNP_001303307.1 V-set 137..250 CDD:284989 31/186 (17%)
IG_like 137..229 CDD:214653 28/165 (17%)
I-set 253..341 CDD:254352 32/99 (32%)
IGc2 268..331 CDD:197706 25/74 (34%)
I-set 346..437 CDD:254352 23/99 (23%)
Ig 349..437 CDD:299845 23/96 (24%)
Ig 459..530 CDD:299845 18/85 (21%)
IG_like 549..628 CDD:214653 20/91 (22%)
IGc2 551..617 CDD:197706 17/72 (24%)
FN3 633..725 CDD:238020 32/289 (11%)
FN3 786..874 CDD:238020 24/102 (24%)
DSCAML1XP_011541219.1 IG_like 43..119 CDD:214653
IGc2 43..110 CDD:197706
Ig 125..218 CDD:299845
IG_like 137..209 CDD:214653
I-set 245..323 CDD:254352 12/77 (16%)
IGc2 252..313 CDD:197706 12/60 (20%)
IGc2 340..401 CDD:197706 11/63 (17%)
I-set 420..514 CDD:254352 33/100 (33%)
Ig 420..510 CDD:299845 31/96 (32%)
IGc2 531..589 CDD:197706 14/62 (23%)
IG_like 619..698 CDD:214653 19/89 (21%)
Ig 627..693 CDD:143165 18/76 (24%)
I-set 702..797 CDD:254352 24/102 (24%)
Ig7_DSCAM 719..797 CDD:143211 18/81 (22%)
I-set 803..896 CDD:254352 5/92 (5%)
Ig 815..903 CDD:299845 3/87 (3%)
FN3 899..993 CDD:238020 13/93 (14%)
FN3 1000..1097 CDD:238020 13/96 (14%)
fn3 1105..1191 CDD:278470 14/91 (15%)
FN3 1203..1294 CDD:238020 24/102 (24%)
IGc2 1318..1382 CDD:197706 11/67 (16%)
FN3 1396..1486 CDD:238020 21/91 (23%)
FN3 1500..1572 CDD:238020 15/71 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

Return to query results.
Submit another query.