DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and kirrel3b

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	XP_021323594.1	Gene:	kirrel3b / 572369	ZFINID:	ZDB-GENE-100713-3	Length:	795	Species:	Danio rerio

Alignment Length:	634	Identity:	143/634 - (22%)
Similarity:	215/634 - (33%)	Gaps:	142/634 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 STPTPTIQVLQFVLVSLLALLAKNAQAHNIPEDAVHITAILGEGVIFNCHVEFPNDHPVPYVLQW 166
            |.|.....:|:..|:..|.....||.....|:|.|   .:.|:.|...|.:  |..|.|...|:
Zfish     5 SPPRRVKMILEVFLILWLTGHGVNAVFSQQPQDLV---VVAGQPVTLPCSI--PGYHGVVLWLR- 63

  Fly   167 DKKVSETGSDLPIYIWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRESDQGWYECKVV- 230
            |......|.||      ..||.:...|          |...|...|.:..:...|...:||:.:
Zfish    64 DGLALGVGRDL------SGYPRYAVVG----------DHGSGEHHLRIQKVELMDDAVFECQAIQ 112

  Fly   231 -FLNRDPKQHKNGTWFHLDVHAPPRF-SVTPEDIIYVNLGDSIILNCQADGT-PTPEILWYKDA- 291
             .:...|.:        |.|..||.. .:|...::.:..||.:.|.|.||.. |...|:|.::.
Zfish   113 AAMRSRPAR--------LTVLVPPDDPMITGGPVVSLRAGDPLNLTCHADNAKPAASIIWIRNGE 169

  Fly   292 --NPVDPSPTVGIFNDG-TELRISTIRHEDIGEYTCIARNGEGQ--VSHTARVIIAGGAVIMV-- 349
              |....|.|  :..|| .|..:||:       |...:....||  :...:...:..|....|
Zfish   170 VLNGAMYSKT--LLRDGRRESTVSTL-------YISASNIESGQKIICRASNKAVPNGKETSVTI 225

  Fly   350 -----PPTN-----QTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSL 404
                 |..|     |..|||..|.|.|.|||.|.....:|.:.||.::||:.....|.:  |.|.
Zfish   226 DIQHLPLVNLSVEPQPVLEGNLVKFHCSAKANPPVTQYKWAKGGSVIKEVSGDTYEVIV--DHSF 288

  Fly   405 IINPIKPDDSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQ 469
            ...|:.        |||||.:|. .:.|..:.|.:..::...|....:......|..|....:|.
Zfish   289 FTEPVS--------CEVTNPLGS-TNISRNVDVYFGPRMAAEPQSLQVDLGSDAVFNCAWTGNPS 344

  Fly   470 LQYVTWTKDKRLLEPYQMKDIVVMANGSLLFTR-VNEEHQGQYACTPYNAQGTAGASGVMDVLVR 533
            |. :.|.|         ....||::|.::|..: |.:|..|:|.|... ......|...:.:.|.
Zfish   345 LT-IVWMK---------RGSGVVLSNENILTLKSVRQEDAGKYVCRAV-VPRVGAAEKEVSLTVN 398

  Fly   534 KPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRIKISGGNITI 598
            .||  |:.....:|...|:..::.|........:|....|:    |.:.||.      :.|..|:
Zfish   399 GPP--TISSTQTHQAPHGEKGQIKCFIRSTPPPDRIAWSWK----ETVLESG------TSGRYTV 451

  Fly   599 ENLRREDFGYYQCVVSNEVATLMAVTQLVIEGTQPHAPYNITGKATESSITLQWLPGYSGGSEYK 663
            |            .||.|...|..:|...|........||.|.          |   .|.||
Zfish   452 E------------TVSTEDGVLSTLTMSNIVPADFQTIYNCTA----------W---NSFGS--- 488

  Fly   664 QDYTIWFREAGVNDWQTISVTPSGSTQ-----VTINGLASGTTYEFQVV 707
                         |.:.|.:...|.:|     ..|.|:|.|....|.|:
Zfish   489 -------------DTEIIRLKEQGGSQDSLPVAVIIGVAVGAFVAFIVL 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	22/114 (19%)
		IG_like	137..229	CDD:214653	20/91 (22%)
		I-set	253..341	CDD:254352	22/95 (23%)
		IGc2	268..331	CDD:197706	18/67 (27%)
		I-set	346..437	CDD:254352	30/102 (29%)
		Ig	349..437	CDD:299845	30/99 (30%)
		Ig	459..530	CDD:299845	16/71 (23%)
		IG_like	549..628	CDD:214653	15/78 (19%)
		IGc2	551..617	CDD:197706	12/65 (18%)
		FN3	633..725	CDD:238020	17/80 (21%)
		FN3	786..874	CDD:238020
kirrel3b	XP_021323594.1	IG_like	35..124	CDD:214653	25/118 (21%)
		Ig2_KIRREL3-like	146..227	CDD:143236	20/89 (22%)
		Ig_2	235..312	CDD:316418	27/87 (31%)
		I-set	316..397	CDD:333254	17/91 (19%)
		Ig5_KIRREL3	399..496	CDD:143306	29/149 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910