DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and aebp1b

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	XP_696022.6	Gene:	aebp1b / 567630	ZFINID:	ZDB-GENE-030131-8546	Length:	1247	Species:	Danio rerio

Alignment Length:	1294	Identity:	232/1294 - (17%)
Similarity:	368/1294 - (28%)	Gaps:	531/1294 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   525 SGVMDVLVRK--PPAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRN 587
            :.|.|:|..|  ||..|:|        ||...::.|..    .::...|.|....||::.....|
Zfish    50 TSVEDLLQVKIIPPYATIE--------VGQHKQLLCKV----SSDAKNINWVSPNGEKVLTKHGN 102

  Fly   588 RIKISG-----GNITIENLRREDFGYYQCVVSN-------------------------------- 615
             :|:..     .::|:.|....:.|.|:||.:|
Zfish   103 -LKVHNHGSVLSSLTVLNANLNNAGIYKCVATNGDTESQATVKLDIILKRMRRDTDRKGREKRLK 166

  Fly   616 -------------------------------------EVATLMAVTQLVIEGTQP---------- 633
                                                 |.:|.:|.|.:....|.|
Zfish   167 EPKPSKKPKASKPTKKPKSEKKGKGEKGGKKKGKKNREESTTVATTTVAPTTTVPMEYEEFYDPE 231

  Fly   634 -------HAPYNITGKA----TESSITLQWLPG---YSGGSEYKQDYTIWFREAGVNDWQTISVT 684
                   ..|...|..|    |.:..|..::|.   ||....| .||           |:....|
Zfish   232 PDQYWDEDFPAETTTVARTTTTPTEKTKDFIPDMDEYSQPDSY-DDY-----------WKVDEPT 284

  Fly   685 PSGSTQVTINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAAPRNVKAATQPPDSFFQL 749
            |:.|.                :.||....|.... ..:|..:|:.|.......::|   |:.:|.
Zfish   285 PTTSV----------------IAGRPADDDDYWD-ARSVEMVENLPFPDGKEISST---DNDWQY 329

  Fly   750 MPDEADLLAYFD-------IYFH---------------------------TDSRGTLVYSPPKLR 780
            ...|...:..|:       .|.|                           .:.|...:|.||...
Zfish   330 TTTEEPTVPPFENSWYEEYEYGHEKKLEEERERLRKEQEEKEREERKRLEEEERERRIYRPPPRV 394

  Fly   781 VKGPKPGPPRNVSVTEVSNGFLIT------------------------------W-QSPLERAHI 814
            .:.||..||..:....:.|..|:|                              | .:|.|:.|.
Zfish   395 YREPKICPPLGMESHRIDNDQLLTSSVFQHRYGSHRARLNIQASGDDDDMNGGAWCANPEEKVHW 459

  Fly   815 VKFYTIKYRTDAQWK-TLNRGQIRPEETQYLVKNLVGGRTYY-------------------FRVL 859
            ::   :..||..::. .:.:|:..|.|:.|:       .|||                   :...
Zfish   460 IE---VDARTLTEFTGVITQGRDDPLESDYV-------STYYVAFSNDSREWTFLHDGYAEWLFF 514

  Fly   860 ANSEKSYESSDEVKFPVPARVKHKAITAGVVGGILFFIVAIILSVCAVKICNKRKRRKQEKEFNM 924
            .||:|:.....:...||.||  :..|......|.:...:.|:  .|.|:  :...:.:.|.|
Zfish   515 GNSDKNTPVLSQFMEPVVAR--YIRILPQSWNGTMCMRMEIL--GCPVQ--DPLSQHQSENE--- 570

  Fly   925 VACRITDARNIAANNHHLHNRSTGSISSGQVPLKKYKQTRISSLTAILIAILHWIWPPDRCTNCH 989
                :|...|:...:|:            .:.::|..:: ||                |.|.|..
Zfish   571 ----VTRRDNLDYTHHN------------YLDMEKLMKS-IS----------------DECPNIT 602

  Fly   990 SIYS-----------------SPNLED-------------GDE------------------DDGG 1006
            ..||                 :|.:.:             |:|                  .||.
Zfish   603 RFYSLGKSFKGLEIYAMEITDNPGVHETGEPEFRYTAGYHGNEALGRELLLMFMQYLCKEYKDGN 667

  Fly  1007 GGRRRSVSRIQRSL------DGRFVLDVEGVSKLGYSQQTLESGNVDVVDGGLFER-RNSNVSQK 1064
            ...|..|...:..|      ||. |...|..|:||  ..||.....|..|  :|:. .:.|....
Zfish   668 PRVRHLVDETRIHLVPSVNPDGH-VKAFEKGSELG--SWTLGHWTEDGHD--IFQNFPDLNNIYW 727

  Fly  1065 SSSDDG---------------GFLSRRNFIT----ARASW--RRPLVASSSQLSLQSAADSARGF 1108
            .|.|.|               |.||....|.    |..||  ..|.|..::
Zfish   728 DSEDKGMVPKLTPNHHIPIPEGILSSNGSIAMETLALISWMESHPFVLGAN-------------- 778

  Fly  1109 LQGLLKIGAKQSAVPPNSQSYFD--------EAVS---GARYQNVLRPYTSSN---NLYGNADRS 1159
            |||    |.|....|      ||        ||:.   |:|.....|.|....   |.|
Zfish   779 LQG----GEKLVTYP------FDMRRLTKESEAMEKKLGSRANRRKRQYEEEEEEPNPY------ 827

  Fly  1160 RPLHINTISGSLSQQQQLYTPSRISRIFSSSPQQLQPHHQQLLLSSGGSGAYPTHFSDLSTVYPP 1224
              |||.....|.|..|:.:.....|  :....:....|||     |.|.......:.|.:..|..
Zfish   828 --LHIGYHQESYSGPQENHAYDHES--YGYHQESYGYHHQ-----SQGYHEETQGYHDETQGYHN 883

  Fly  1225 -----NSAERSSHNLSSRYRY----------YSQELPSLRTIQEETRR------QQQQKQHPLED 1268
                 ::..:..||.:.||.:          |.:..|       |..|      :|:::...:||
Zfish   884 ENQGYHNENQGYHNENQRYHHEGYSEGYNEGYQEGYP-------EGYRGGYGEGEQEEEIRMVED 941

  Fly  1269 H--FVPLQLPSPPSWR----SYYQSQASYRP--------RTRWYP-------------------- 1299
            .  |..|.:....:.|    ||.:...|..|        |.:|.|
Zfish   942 QSLFRWLAISYASTHRTMTQSYQRGCHSDDPTGGMGIVNRAKWKPIPGSMDDFSYLHTNCFELSV 1006

  Fly  1300 -------RHHSRLFSNRQQQHE---MLSPLPQLNLNLRNSMNPGGLEASPESRSSSSGFGSKNTS 1354
                   .|.|.|.  |:.:|.   :|:.:.|::..::..:...  |.:|.:.::.|..|    .
Zfish  1007 FLGCDKFPHQSELL--REWEHNREALLTFMAQVHRGIKGVVRDN--EGNPITNATVSVEG----V 1063

  Fly  1355 NHPGSTSE----WRLLPP--YRAPPSPPKHSGYFGGQQAQGQTPHGSYSY----PRATTPPYTM- 1408
            ||...|.|    ||||.|  ||..            .:|:|.:|......    |.||...:.:
Zfish  1064 NHDVKTGEAGDYWRLLNPGEYRVT------------ARAEGYSPFTRLCVVGFDPGATLCNFDLN 1116

  Fly  1409 -AHW--LEMISRLNAATDSNLPKAPCPVDVGSVDG--HYEFDP-ATPTPSASSMLREDL 1461
             ::|  ::.|..|:......|      :..||.:|  ||.... ..|..::..|.|..|
Zfish  1117 KSNWDRIKQIMALHGNKPIRL------LSSGSRNGVRHYSHSSNQIPVSNSGDMSRARL 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989
		IG_like	137..229	CDD:214653
		I-set	253..341	CDD:254352
		IGc2	268..331	CDD:197706
		I-set	346..437	CDD:254352
		Ig	349..437	CDD:299845
		Ig	459..530	CDD:299845	1/4 (25%)
		IG_like	549..628	CDD:214653	20/152 (13%)
		IGc2	551..617	CDD:197706	15/139 (11%)
		FN3	633..725	CDD:238020	20/115 (17%)
		FN3	786..874	CDD:238020	21/138 (15%)
aebp1b	XP_696022.6	Ig	56..147	CDD:299845	22/103 (21%)
		IG_like	62..145	CDD:214653	20/95 (21%)
		FA58C	402..555	CDD:238014	28/166 (17%)
		FA58C	403..556	CDD:214572	27/166 (16%)
		Peptidase_M14_like	577..1036	CDD:299699	99/540 (18%)
		Peptidase_M14NE-CP-C_like	1040..1115	CDD:200604	21/92 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900