DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and igsf9ba

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	XP_009289969.2	Gene:	igsf9ba / 567389	ZFINID:	ZDB-GENE-060503-729	Length:	1475	Species:	Danio rerio

Alignment Length:	1527	Identity:	417/1527 - (27%)
Similarity:	626/1527 - (40%)	Gaps:	357/1527 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 VLVSLLALLAKNAQ-AHNIPEDAVHITAILGEGVIFNCHVEFP-NDHPVPYVLQWDKKVSETGSD 176
            ::.|:.:.....|| ||.:.|:...:||..||.|:..|.|..| |....|||::|.|    .|..
Zfish     8 LIASVFSTRGTAAQGAHGVREEPQFVTARAGESVVLGCDVSHPLNGQQTPYVVEWFK----FGVP 68

  Fly   177 LPIYIWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRESDQGWYECKVVFLNRDPKQHKN 241
            :|.:|.:..||.|::..|.||.|.      .|.|||.:..:|..|||||||:|:.|.:......|
Zfish    69 IPFFINFRFYPPHVDPEYAGRASL------HGKASLQIEQVRSEDQGWYECRVLMLEQQYDTFHN 127

  Fly   242 GTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTPEILWYKDANPVDPSPTVGIFNDG 306
            |:|.||.|:|||.||.||...:....|.||.|.|.|.|.|.|.:.|.::.:.:..:....: :||
Zfish   128 GSWVHLTVNAPPTFSDTPPQYVEAREGGSITLTCTAFGNPKPVVTWLREGDQLTSTRKYTV-SDG 191

  Fly   307 TELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVPPTNQTKLEGEKVIFSCEAKAM 371
            : |.:..|..||.|.|:|.|.:.:|:..||.|:::.|...|:.||.|.|....:...|:|:|:|.
Zfish   192 S-LTVQAITREDRGAYSCRAHSDQGEALHTTRLLVQGPPYIVTPPENITVNISQNAQFTCQAEAY 255

  Fly   372 PGNVTVRWYREGSPVREVAALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQSASAYLS 436
            |||:|..||.|...|.....|:.||.|..||:|||..:||:|:|:|.|..:|.:|...||||||:
Zfish   256 PGNLTYTWYWEEDNVYFKNDLKLRVRIFIDGTLIIYRVKPEDAGKYTCSPSNSLGISPSASAYLT 320

  Fly   437 VEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTKDKRLLEPYQMKDIVVMANGSLLFT 501
            |:|||:|...|.|.|:|.:|:|:::|.:.::|.:..|.|.||...|...:......|.:||:...
Zfish   321 VQYPARVVNMPPVIYVPRKLSGIIRCPVDANPPVTSVRWEKDGYPLRIEKYPGWSQMTDGSIRVA 385

  Fly   502 RVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEPETLYQRKVGDSVEMHCDALEAEGT 566
            .|.|:..|.|.|.|||..||.|.|....::::.||.|.|.|...|:::.|..:.:.|.|  :...
Zfish   386 EVTEDSLGTYTCVPYNVLGTMGQSPPATLVLKDPPYFNVRPGGEYRQEAGRELVIPCAA--SGDP 448

  Fly   567 ERPTIKWQRQEGEQLTESQRNRIKISGGNITIENLRREDFGYYQCVVSNEVATLMAVTQLVIEGT 631
            |.|||:| |:.|:. :.|:.|  .:..|::...:|.:||.|.::||.:|.|.::.|.|:|.:.||
Zfish   449 EIPTIQW-RKVGKP-SRSKHN--LLPSGSLQFVSLSKEDHGEWECVATNVVTSITASTRLFVIGT 509

  Fly   632 QPHAPYNITGKATESSITLQWLPGYSGGSEYKQDYTIWF------REAGVNDWQTISVTPSGSTQ 690
            .||||.|:...|:.||..:.|.|||.||  ::|.:::|:      .:.|.:||.:|.| |.....
Zfish   510 SPHAPTNVHVSASTSSANVSWEPGYDGG--FEQTFSVWYGPVKVKNDVGTHDWLSIPV-PGSQMW 571

  Fly   691 VTINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAAPRNVKAATQPPDSFFQLMPDEAD 755
            :.:.||...|.|:|.|:.:|.||.|..|:|:||.|             ...|
Zfish   572 LVVQGLEPKTAYQFSVLAQNKLGTGPFSEVVTVTT-------------GGYP------------- 610

  Fly   756 LLAYFDIYFHTDSRGTLVYSPPKLRVKGPKP----GPPRNVSVTEVSNGFLITWQSPLERAHIVK 816
                                     :..|:|    .|||.::......|.|:||..|......:.
Zfish   611 -------------------------ISTPEPLVLLTPPRCLTANRTQQGVLLTWLPPANHTSPID 650

  Fly   817 FYTIKYRTDAQWKTLNRGQIRPEETQYLVKNLVGGRTYYFRVLANSEKSYESSDEV-------KF 874
            .|.|::|...:|:.|: ..|...||:.:.::|:....|.||.||..:.....|..|       .|
Zfish   651 RYVIEFRLGEKWEVLD-DLIPATETEIIARDLIQDSWYEFRALAIMDDLVSESSNVVGVSSTDPF 714

  Fly   875 PVPARVKH----KAITAGVVGGILFFIVAIILSVCAVKICNKRKRRKQEKEFNMVACRITDARNI 935
            | |..:..    |.:.||:|..|.|...||:.|..|....||:.|||.:::.: ....||..|..
Zfish   715 P-PTEISDEGLAKPVVAGIVATICFLAAAILFSTLAACFVNKQHRRKLKRKRD-PPLSITHTRKS 777

  Fly   936 AANNHHL------------HNRS-------TGSISSGQVPLKKYKQTRISSLTAILIAILHWIWP 981
            ..:...|            .:||       :..:|||::..:....:|..||.::
Zfish   778 IESPPPLTPLPGIEPYWEEPDRSSYRPPSTSPQLSSGKISPESIASSRPPSLASV---------- 832

  Fly   982 PDRCTNCHSIY----SSPNLED-----GDEDDGGGGRRRSVSR-----------IQRSLDGRFVL 1026
                 ..|.:|    .||..|.     .........::.|||:           |.|..|||||:
Zfish   833 -----GGHGLYVKKLPSPRKEKELSLYKKTKRAITSKKYSVSKHEAEVTTPIELISRGPDGRFVM 892

  Fly  1027 DVEGVSKLGYSQQTLESGNVD----VVDGGLF-ERRNSNVSQKSSSDDGGFLSRRNFITARASWR 1086
            |...:      ..:|:...::    |.:..|: |.|.|:    ..:||.|.|.
Zfish   893 DPNDI------DSSLKPRRIEGFPFVEESDLYPEFRQSD----EENDDPGPLP------------ 935

  Fly  1087 RPLVASSSQLSLQSAADSARGFLQGLLKIGAKQSAVPPNSQSYFDEAVSGARYQNVLRPYTSSNN 1151
             |::|:                      :..:.|.|..:.:||........|:|
Zfish   936 -PVMAT----------------------LRPQISPVSSSQESYMQPPAYSPRFQ----------- 966

  Fly  1152 LYGNADRSRPLHINTIS-GSLSQQQQLYTPSRISRIFSSSPQQLQPHHQQLLLSSGGSGAY---- 1211
                    ||:...:|| ||..|.......|...|:|...|          .....||||.
Zfish   967 --------RPMEGMSISEGSRLQATGQSRVSHFHRVFPPGP----------FYGYIGSGAEVELH 1013

  Fly  1212 -PTHFSDLSTVYPPNSAERSSHNLSSRYRYYSQELPSLRTIQEETRRQQQQKQHPLEDHFVPLQL 1275
             |.:..|:|   |.:||..||.:       |..|.|.......|.|.:.:..|:....|.:|| :
Zfish  1014 PPFYMPDVS---PRSSAMSSSPS-------YPPEGPFRHPTIPEEREELRIHQYGASGHALPL-V 1067

  Fly  1276 PSPPSWRSY-------YQSQASYRPRTRWYPRHHSRLFSNRQQQHEMLSPLPQLNLNLRNSMNPG 1333
            .||||.||.       :.......||....|||.|.|      ..::..|.|.
Zfish  1068 HSPPSSRSTEIWQPPDFPFLGQEGPRLALPPRHSSYL------HRDLPEPPPY------------ 1114

  Fly  1334 GLEASPESRSSSSGFGSKNTSNHPGSTSEWRL--------LPPYRAPPSPP--KHSGYFGGQQAQ 1388
                ...||:.|:      ||..|.|::..:|        ..|.|.||..|  ||   ...||||
Zfish  1115 ----PSHSRTVST------TSQLPSSSAFLQLEAPRTHLSRSPGRFPPQGPSAKH---ITMQQAQ 1166

  Fly  1389 --GQTPHGSYS-------YPRATT---PPYTMAH-------------WLEMISRLNAATDSNLPK 1428
              ||..|.::.       |..|||   .|.|: |             |:.             |:
Zfish  1167 TLGQLRHTAHGMGVPVLPYSGATTRMGSPSTL-HSESSDGWRSEAQPWMS-------------PR 1217

  Fly  1429 APCPVDVG---SVDGHYEFDPATPTPSAS---------------SMLREDLNLHIDTHPYHHHTL 1475
            |...:|:|   .|.......|.|.||.:|               |:||...:..:.....|..::
Zfish  1218 AARKMDLGLQQVVLQPSRLSPLTQTPPSSHAGSPDILVRPPPRPSILRSSRSQEMPESARHPASV 1282

  Fly  1476 GPLSGSLLHSHA--PYGG--GARKQRSLPAHL 1503
            .....||..|.|  |..|  |.|...|..||:
Zfish  1283 SFSRRSLSSSPATSPTQGQSGQRPSLSYRAHM 1314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	43/113 (38%)
		IG_like	137..229	CDD:214653	36/92 (39%)
		I-set	253..341	CDD:254352	29/87 (33%)
		IGc2	268..331	CDD:197706	20/62 (32%)
		I-set	346..437	CDD:254352	40/90 (44%)
		Ig	349..437	CDD:299845	39/87 (45%)
		Ig	459..530	CDD:299845	22/70 (31%)
		IG_like	549..628	CDD:214653	24/78 (31%)
		IGc2	551..617	CDD:197706	20/65 (31%)
		FN3	633..725	CDD:238020	36/97 (37%)
		FN3	786..874	CDD:238020	25/98 (26%)
igsf9ba	XP_009289969.2	IG	30..115	CDD:214652	36/94 (38%)
		I-set	139..225	CDD:254352	29/87 (33%)
		I-set	229..321	CDD:333254	40/91 (44%)
		Ig	345..415	CDD:325142	22/69 (32%)
		Ig	438..503	CDD:319273	21/70 (30%)
		FN3	511..606	CDD:238020	36/97 (37%)
		FN3	622..706	CDD:238020	23/84 (27%)
		Atrophin-1	<924..1361	CDD:331285	115/515 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I8036
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1619
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D151368at33208
OrthoFinder	1	1.000	-	-		FOG0002337
OrthoInspector	1	1.000	-	-		otm24272
orthoMCL	1	0.900	-	-		OOG6_104975
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1123
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.730