DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and paplna

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	XP_005169942.1	Gene:	paplna / 562930	ZFINID:	ZDB-GENE-070815-4	Length:	1187	Species:	Danio rerio

Alignment Length:	391	Identity:	89/391 - (22%)
Similarity:	150/391 - (38%)	Gaps:	95/391 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 YPEHIEEGYKG--RVSRVSQDSPFGSASLNLTNIRESDQGWYECKVVFLNRDPKQHKNGTWFHLD 248
            :|.|::....|  |..|..|.:   |.::..:|...|   |....|.....||.
Zfish   793 FPAHVQLSSSGAHRAQRAHQPA---SNAMQQSNPAAS---WTAEGVSIDKTDPS----------- 840

  Fly   249 VHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTPEIL--WYKDANPVDPSPTVGIFNDGTELRI 311
                     |.|.::    |..::|.|:....|:..:|  |.:|..||||:...... ||: |.:
Zfish   841 ---------TVEGLV----GQRVVLPCRVTPPPSSAVLVEWRRDGVPVDPTRHEQQL-DGS-LLV 890

  Fly   312 STIRHEDIGEYTCIARNGEGQVSHTARVIIAG----GAVIMVPPTNQTKLEGEKVIFS------C 366
            ..|..:|.|.:.|:|...:.:......:.::|    .|.|....::|:........|:      .
Zfish   891 GPITLQDSGWFLCVATRDDKRDHRYIYLSVSGSSQNNAGISEVDSSQSYTSQSSSRFNIDYSPLV 955

  Fly   367 EAKA----------MPGN----VTVRWYREGSPVREVAALETRVTIRKDGSLIINPIKPDDSGQY 417
            ||:|          :|.:    ||:.|.|.|.|:..:     |.:...||:|:|..:..||||.|
Zfish   956 EARAGQTAKLQCSVLPVSAIHAVTIHWSRAGQPLNSL-----RHSQHSDGTLVIKQLTADDSGLY 1015

  Fly   418 LCEVTNG------------IGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQL 470
            .|.||:.            :||.:...|.:.|:         .||....:||.||      :.:.
Zfish  1016 TCTVTDAQKFEERQVQLRVLGDLRITKAPIDVD---------VVQGSTAQLACVV------TGEN 1065

  Fly   471 QYVTWTKDKRLLEPYQMKDIVVMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKP 535
            ..|.|:::...:.|...: :.|.|:|:|:...|....:|.|.|..|.  ||...|...::.:.|.
Zfish  1066 VNVGWSRNGVPVRPDGHR-VHVSADGTLILNNVQSVDEGTYTCNAYT--GTLSVSAAAEIRLAKT 1127

  Fly   536 P 536
            |
Zfish  1128 P 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	13/65 (20%)
		IG_like	137..229	CDD:214653	10/44 (23%)
		I-set	253..341	CDD:254352	21/89 (24%)
		IGc2	268..331	CDD:197706	19/64 (30%)
		I-set	346..437	CDD:254352	29/122 (24%)
		Ig	349..437	CDD:299845	28/119 (24%)
		Ig	459..530	CDD:299845	17/70 (24%)
		IG_like	549..628	CDD:214653
		IGc2	551..617	CDD:197706
		FN3	633..725	CDD:238020
		FN3	786..874	CDD:238020
paplna	XP_005169942.1	TSP1	24..75	CDD:214559
		ADAM_spacer1	181..293	CDD:310520
		TSP1	303..356	CDD:214559
		TSP1	388..442	CDD:214559
		TSP1	449..498	CDD:214559
		TSP1	504..557	CDD:214559
		KU	720..771	CDD:238057
		Ig_3	839..906	CDD:316449	21/92 (23%)
		IGc2	960..1022	CDD:197706	20/66 (30%)
		I-set	1039..1121	CDD:333254	23/99 (23%)
		PLAC	1142..1173	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900