DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and sdk2a

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	XP_021327143.1	Gene:	sdk2a / 561852	ZFINID:	ZDB-GENE-091008-1	Length:	2224	Species:	Danio rerio

Alignment Length:	1607	Identity:	327/1607 - (20%)
Similarity:	553/1607 - (34%)	Gaps:	454/1607 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 VSRVSQDSPFGSASLNLTNIRESDQGWYECKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDI 262
            |:|..:|  || ..|.::....||.|:|:|:....:........|.:.|:..|  |:|...|:..
Zfish   284 VNRGLRD--FG-RRLTISGPLVSDSGYYQCEASLRSSSAPSVSAGAYLHVLEH--PQFVKEPDRH 343

  Fly   263 IYVNLGDSIILNCQADGTPTPEILWYKDANPVDP--SPTVGIFNDGTELRISTIRHEDIGEYTCI 325
            |...:...:.:.|||.|.|.|:|:|||||.|:.|  :|...:...|: |:|:.:..:|.|.:.|.
Zfish   344 ITAEMEKVVDIPCQARGVPQPDIVWYKDAVPISPVKTPRYRVLVGGS-LQINGLLPDDTGMFQCF 407

  Fly   326 ARNGEGQV-SHTARVIIAGGAVIMVPPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREV 389
            |||..|:: ::|...:.:....|...|::...::|..:|..||....| ...:.|.:....:...
Zfish   408 ARNLAGEIQTNTYLAVTSIAPNITAGPSDSAVIDGMSIILHCETSGAP-RPAITWQKAERVLASG 471

  Fly   390 AALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPF 454
            :....|.|:.:.|||:|:|....|:|.|.|..:|..|..: |||.|.|....::|..|..|.:..
Zfish   472 SVQLPRFTLLESGSLLISPSHLLDAGSYTCMASNSRGIDE-ASADLVVWARTRITNPPQDQSVIK 535

  Fly   455 RLAGVVQCYIKSSPQ--LQYVTWTKDKRLLEPYQMKDIVVMANGSLLFTRVNEEHQGQYAC--TP 515
            .....:.|.:...|.  :::: |.|...:::......:.:.:||:|..::......|.|.|  |.
Zfish   536 GTKAAMTCGVTHDPSVTVRHI-WEKGGAVIDVKSSPRLRLDSNGTLHISQTWSGDIGTYTCRVTS 599

  Fly   516 YNAQGTAGASGVMDVLVRKPPAFTVEPETLYQR-KVGDSVEMHCDALEAEGTERPTIKWQRQEGE 579
            .....|..|    .:.||:.|.   .||.|... .:.:...::....:|.....|.|::..:..|
Zfish   600 VGGNDTRNA----HLRVRQLPH---APENLIATLSISERRTINLTWAQAFDGNSPLIRYILEVSE 657

  Fly   580 Q-------LTESQRNRIKISGGNITIENLRREDFGYYQCVV--------SNEVATLMAVTQLVIE 629
            .       |...:...|.:..|.:    :....:.:..|.|        |.|.|      ::.:.
Zfish   658 NNAPWTVLLANIEPESISVIVGGL----IPARSYQFRLCAVNDVGKGQFSRETA------RVSLP 712

  Fly   630 GTQPHAPYN--ITGKATESSITLQWLP---GYSGGSEYKQDYTIWFREAGVN-DWQTISVTPSGS 688
            ...|.||..  |....|..||.:||.|   .:..|.  .|.|.|.:..:|:. |.|..::|....
Zfish   713 EEPPSAPPQTVIASGRTNQSIMIQWQPPPESHQNGP--LQGYIIRYCLSGLPVDCQMKNITNPDQ 775

  Fly   689 TQVTINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAA-PRNVKAA-----------TQ 741
            |.:.:..|...|.||.:|...|..|.|:.|..:|..||:..|.. |.||:|.           :.
Zfish   776 TNLLLEDLIIWTNYEIEVAAYNGAGQGVYSPKVTEWTLQGVPTVPPGNVQAEAVNSTTVRFTWSA 840

  Fly   742 PPDSFFQLMPDEADLLAY-------------------------------FDIYFHTDSRGTLVYS 775
            |...|...:.....|||:                               |..||..    .|.::
Zfish   841 PSPQFINGINQGYKLLAWEPGHEEDVTLVTVRPNFQDSVHVGYISGLKKFTEYFTC----VLCFT 901

  Fly   776 PP---------KLRVKGPKPGPPRNVSVTEVSNGFL-ITWQSPLERAHIVKFYTIKYRTDAQWKT 830
            .|         ::|.....|||..::|.||:.:..| ::|:.|.|:..|:..|.|      .|:.
Zfish   902 TPGDGPRSTAQRIRTHEDTPGPVGHLSFTEILDTSLKVSWKDPPEKNGILTGYRI------SWEE 960

  Fly   831 LNRGQIR-----PEETQ-YLVKNLVGGRTYYFRV--LANSEKSYESSDEVKFPVP---------- 877
            .||...|     |..|| |.|..|....||..:|  :.|..:...||..:...||
Zfish   961 FNRTNTRVTHYLPNMTQEYRVTGLTALTTYTIQVAGMTNKGQGQLSSSTISSGVPPEMPGPPTNI 1025

  Fly   878 --ARVKHKAIT---------------------AGVVGGILFFIVAIILSVCAVKICNKRKRRKQE 919
              :.:..:::|                     .||:|....:::...||       |:...|..|
Zfish  1026 AISNISPRSVTLQFKPGYDGKTSISRWLIEAQIGVIGENEEWVMVHQLS-------NEPDARSLE 1083

  Fly   920 --------------KEFNMVAC-----------RITDARNIAANNHHLHNRSTGSISSGQVPLKK 959
                          ::.|:|..           .:....:||..|..|...|..|:....|||.:
Zfish  1084 VQGLNPYTYYRFRMRQVNIVGTSPPSQPSRKIQTLQAPPDIAPANITLRTASETSLWLRWVPLPE 1148

  Fly   960 Y-------------KQTRISSLTAILIAILHWIWPPDRCTNCHSIYSSPNLEDGDEDD------- 1004
            :             :.:|:.|....|..|:     |||.....:|   .:||:..|.:
Zfish  1149 WEYNGNPELVGYRVQYSRLGSKVGFLSHII-----PDRQEREFTI---EDLEEWTEYEVKVQAFN 1205

  Fly  1005 --GGG-------GRRR---------SVSR-----------------------------IQRSLDG 1022
              |.|       ||.|         :||.                             :.:..|.
Zfish  1206 GIGPGPWSQPVHGRTRESVPSSGPANVSAFATTSSSILVRWGDVPETDRNGLILGYKVVYKEKDA 1270

  Fly  1023 RFVL---DVEG-------VSKLG----YSQQTLESGNVDVVDG-----GLFERRNSNVSQKSSSD 1068
            ..||   .|||       ::.||    |..|.|....:.  ||     .:|||         :.|
Zfish  1271 ESVLHFWTVEGNTTYSVQLTGLGKYVLYEIQVLSFTRIG--DGMPSSPPIFER---------TLD 1324

  Fly  1069 D------GGFLSRRNFITARASWRRPLVASSSQLSLQSAADSARGFLQGLLKI-GAKQSAVPPNS 1126
            |      |.........:.|..|:.|...:...|:.|.|      |.:....| .|....:.|::
Zfish  1325 DVPGPPVGILFPEVRTSSVRLIWQPPAQPNGIILAYQIA------FRRNSSSITSANVDVLNPSA 1383

  Fly  1127 QSYFDEAVSGARYQNVLRPYTSSNNLYGNADRSRPLHINTISGSLSQQQQLYTPSRISRIFSSSP 1191
            :.|   ..:|.:.::|.....::....|..:.:..|.:.|        ::...|...||  ...|
Zfish  1384 RQY---TATGLKPESVYVFRLTAQTRKGWGEAAEALVVTT--------EKRARPQPTSR--PVVP 1435

  Fly  1192 QQLQPHHQQLLLS--SGGSGAYPTHFSDLSTVYPPNS-----AERSSHNLSS----------RYR 1239
            |: :...:.:|||  .|..|..|..:..:.....|:|     :...:|..:|          .|:
Zfish  1436 QE-EVQARSVLLSWEPGSDGLSPIRYYTIQYRELPDSNWTVHSASVNHEATSYVIDRLKPFTSYQ 1499

  Fly  1240 Y------------YSQELPSLRTIQEETRRQQQQKQHPLEDHFVPLQLPSPPSWRSYYQSQASYR 1292
            :            ||:|..::.|:|:                 .|.:.|          :..|..
Zfish  1500 FRVKATNDIGDSEYSEESEAITTLQD-----------------APDKAP----------TILSVT 1537

  Fly  1293 PRT------RWYPRHHSRL--------FSNRQQQHEMLSPLPQLNLNLRNSMNPGGLEA---SPE 1340
            |.|      ||.|.....:        ...|:.:::.|.     :..:|...:|.|..|   :|.
Zfish  1538 PHTTTSVLVRWKPPPEEEINGILLGFRVRYRELRYDRLR-----SFTVRTVNSPAGNWAELTAPY 1597

  Fly  1341 -----SRSSSSGFGSKNTSNHPGSTSEWRLLPPYRA----PPSPPKHSGYFGGQQAQGQTPHGSY 1396
                 |.||.:.:...|.:.|  ...|.| |..|.|    |.|.|:.  .|.|:..
Zfish  1598 SVRNLSESSLTQYELDNLNKH--KRYEIR-LSVYNAVGEGPTSSPQE--VFVGEAV--------- 1648

  Fly  1397 SYPRATTPPYTMAHWLEMISRLNAATDSNLPKAPCPVDV--GSVDG----HYEFDPATPTPSASS 1455
                .|..|..:|......::|:...|      |.||:.  |.:.|    ::||.....|....:
Zfish  1649 ----PTAAPQNVAIQSSTATQLDVTWD------PPPVEAQNGDIQGYKIYYWEFQLQNETERLRT 1703

  Fly  1456 MLREDLNLHIDTHPYHHHTLGPLSG--SLLHSHAPYGGGARKQRSLP 1500
            :...:|::.:..          |:|  :.:.|.:.:.......||||
Zfish  1704 LFLPELSVKLKN----------LTGYTTYMISVSAFNAAGDGPRSLP 1740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	13/51 (25%)
		IG_like	137..229	CDD:214653	11/30 (37%)
		I-set	253..341	CDD:254352	30/90 (33%)
		IGc2	268..331	CDD:197706	24/64 (38%)
		I-set	346..437	CDD:254352	25/90 (28%)
		Ig	349..437	CDD:299845	24/87 (28%)
		Ig	459..530	CDD:299845	13/74 (18%)
		IG_like	549..628	CDD:214653	12/93 (13%)
		IGc2	551..617	CDD:197706	10/80 (13%)
		FN3	633..725	CDD:238020	29/97 (30%)
		FN3	786..874	CDD:238020	29/96 (30%)
sdk2a	XP_021327143.1	IGc2	66..124	CDD:197706
		Ig	157..213	CDD:325142
		IGc2	259..313	CDD:197706	11/31 (35%)
		Ig	352..420	CDD:319273	25/68 (37%)
		Ig	442..518	CDD:325142	23/77 (30%)
		I-set	523..612	CDD:333254	16/93 (17%)
		FN3	616..706	CDD:238020	14/96 (15%)
		fn3	719..805	CDD:306538	25/87 (29%)
		FN3	820..916	CDD:238020	14/99 (14%)
		FN3	921..1009	CDD:238020	29/93 (31%)
		FN3	1019..1113	CDD:238020	11/100 (11%)
		FN3	1125..1220	CDD:238020	22/102 (22%)
		fn3	1229..1314	CDD:306538	15/86 (17%)
		FN3	1327..1420	CDD:238020	16/101 (16%)
		FN3	1437..1521	CDD:238020	14/84 (17%)
		FN3	1530..1642	CDD:238020	27/131 (21%)
		FN3	1652..1745	CDD:238020	20/105 (19%)
		FN3	1750..1838	CDD:238020
		FN3	1871..1942	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910