DRSC/TRiP Functional Genomics Resources

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Protein Alignment tutl and robo4

DIOPT Version :10

Sequence 1:NP_001303307.1 Gene:tutl / 46015 FlyBaseID:FBgn0010473 Length:1536 Species:Drosophila melanogaster
Sequence 2:XP_689255.3 Gene:robo4 / 560765 ZFINID:ZDB-GENE-020809-1 Length:1134 Species:Danio rerio


Alignment Length:1245 Identity:255/1245 - (20%)
Similarity:405/1245 - (32%) Gaps:399/1245 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   233 NRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTPEILWYKDANPVD-- 295
            :||....:.|:....:::. ||....|.|:: |.:|....|:|:|:|.|.|.|.|.::..|:|  
Zfish    52 HRDRAHRRKGSRLVSEINL-PRIVHHPSDVV-VRVGSPATLSCRAEGNPEPTIQWLRNGQPLDTD 114

  Fly   296 -----PSPTVGIFNDGTELRISTI------RHEDIGEYTCIARNGEGQ-VSHTARVIIAG-GAVI 347
                 ..|.|  ..||:....|.:      .||.:  |.|||.|..|. .|..|.:.||. ....
Zfish   115 KMDAQSQPIV--LPDGSLFFFSVVPGRKGQSHEAV--YACIAHNSIGNATSRNASLHIAALREDF 175

  Fly   348 MVPPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIINPIKPD 412
            .|.|::.....||....:|..........|.|.::|..:.......|.:    .|.|||.|.:.:
Zfish   176 RVQPSDVEVAIGEMATINCSPPVGHPEPNVTWRKDGILINSSNEHYTEL----KGKLIIAPAQKN 236

  Fly   413 DSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTK 477
            |||.|.|..:|.||..:|.:|.|||                                        
Zfish   237 DSGVYSCIASNMIGVRESRAARLSV---------------------------------------- 261

  Fly   478 DKRLLEPYQMKDIVVMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEP 542
               |.:|                                             ||:|||...:|: 
Zfish   262 ---LAKP---------------------------------------------VLLRKPEDVSVQ- 277

  Fly   543 ETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRIKIS-GGNITIENLRREDF 606
                   :|:|.:..|   ||:|...|:|:|.|::|    .....|..|: ..::.|..:..:|.
Zfish   278 -------LGESAQFFC---EADGDPMPSIEWSREQG----PLPNGRYLINPDHSLQIHYVTAQDM 328

  Fly   607 GYYQCVVSNEVATLMAVTQLVIE---GTQPHAPY-----------NITGKATESSIT-LQW-LPG 655
            |.|.|.|.|::...:|..||::|   ||:....:           |:|..:|.|::: :.| |..
Zfish   329 GRYSCTVENKLGVSVASAQLLVEDAGGTRLRDLHKELSALRVSLENVTVMSTASNMSQVMWKLQS 393

  Fly   656 YSGGSEYKQDYTIWFRE--AGVNDWQTISVTPSGSTQVTINGLASGTTYEFQV--VGRNVLGDGM 716
            :.....|.:.:.:.:|.  ...:|| |....|..|....:..|..|..|||:|  .|.::.  |.
Zfish   394 FGSQPHYLEGFEVLYRSLLPASSDW-TAQRVPQPSLHTHVGPLKRGYKYEFKVRPYGSSLY--GR 455

  Fly   717 MSKVMTVRTLEDAP-AAPRNVKAATQPPDSFFQLMPDEADLLAYFDIYFHTDSRGTLVYSPPKLR 780
            .|....:|..|..| |||::|...          ||.|                           
Zfish   456 ESNTRHLRVPEIVPSAAPQDVSIT----------MPAE--------------------------- 483

  Fly   781 VKGPKPGPPRNVSVTEVSNGFLITWQSPLERAH--IVKFYTI-----KYRTDAQWKTLNRGQIRP 838
                     ||.:|.       ::|:.|...||  |::.|.:     :.:|...| |::.|....
Zfish   484 ---------RNDTVH-------LSWEPPPHDAHNGIIQGYQVWCVESEEQTSFNW-TVDSGTHSI 531

  Fly   839 EETQYLVKNLVGGRTYYFRVLA-NSEKSYESSDEVKFPVPARVKHKAITAGVVG----------- 891
            |     :..|:..|.|:..|.| |.......||..|..:.:|::......|::.           
Zfish   532 E-----IFTLLPSRLYWVTVAAVNGAGVGVQSDPYKLLIESRLEATPYQTGILSMSHFVSVIKEP 591

  Fly   892 ------GILFFIVAIILSVCAVKICNKRKRRKQEKEFNMVACRITDARNIAANNHHLHNRSTGSI 950
                  |.|.:.|.:|.:|...:                               .|:...:....
Zfish   592 VFIGSVGTLLWCVLMITAVFLYR-------------------------------RHIRPANPSGK 625

  Fly   951 SSGQVPLK------KYKQTRISSLTAILIAILHWI---WPPDRCTNCHSIYSSPNLEDGDEDDGG 1006
            |||...|:      |::.....|         .||   |.|...:.......:|:.|:       
Zfish   626 SSGLYRLESEDLIIKHRMAAPDS---------PWISGGWRPGSNSEPKQGLWTPSQEN------- 674

  Fly  1007 GGRRRSVSRIQRSLDGR-------FVLDVEGVSKLGYSQQTLESGNVDVVDGGLFERRNSNVSQK 1064
            .|.||:...|....|..       .|.|..||....|         ||:...||   :..|...:
Zfish   675 SGLRRTTLPITVKKDPNPLRSAVPIVPDNCGVYGTFY---------VDLTGNGL---KTFNSPGR 727

  Fly  1065 SSSDDGGFLSRRNFITARAS----------------WRRPLVASSSQ-LSLQSAADSARGFLQG- 1111
            ......|....:|..|.|.:                |:|.|.|..:. :..:|...:.:..|.. 
Zfish   728 CPRMPHGNSQLQNSETIRITEPIVKTAVVRELQALPWKRTLPAQPNMGVKKESWEKNVKRELHAV 792

  Fly  1112 ----LLKIGAKQSAV--PPNSQSYFDEAVSGARYQNVLRP--------YTSSNNLYGNADRSRPL 1162
                |:.:..:..||  .||.|..|.:..:|...:.| :|        |::|..|........||
Zfish   793 KSAPLMPLNQQALAVCSAPNHQQRFSQHPAGGVSEPV-KPLSSPRILHYSASLQLVDMLPSPPPL 856

  Fly  1163 HINTISGSLSQQQQLYTPSRISRIFSSSPQQLQPHHQQLLLSSGGSGAYPTHFSDLSTVYPPNSA 1227
            .:.. :.|||.:.:....::::....|        .|.:..:||..|.     :..:|..|.|  
Zfish   857 PMED-NHSLSSEDESTRSTKLTVDIGS--------QQSVCAASGLQGP-----ASANTGCPNN-- 905

  Fly  1228 ERSSHNLSSRYRYYSQELPSLRT--IQEETRRQQQQKQHPLEDHFVPLQL-PSPPSWRSYYQSQA 1289
             .|...||..|.:.|.....|.|  .|:.|...|...|:        ::: |.|....:.:||..
Zfish   906 -HSPAQLSPSYSHLSTASFCLSTDDYQDTTLSTQGHTQY--------MEISPKPQGQSTSHQSTP 961

  Fly  1290 SYRPRTRWYPRHHSRLFSNRQQQHEMLSPLPQLNLNLRNSMNPGGLEASPESRSSSSGFGSKNTS 1354
            | .||.                    .||.|.|..    ...||..|...|..:...|.......
Zfish   962 S-MPRP--------------------FSPTPTLGY----ICGPGDREMDEEQETVPIGLRRATLR 1001

  Fly  1355 NHPGS-TSEW 1363
            :.|.| .|||
Zfish  1002 STPSSCCSEW 1011

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tutlNP_001303307.1 V-set 138..250 CDD:462230 3/16 (19%)
I-set 253..341 CDD:400151 31/101 (31%)
Ig strand B 271..275 CDD:409353 1/3 (33%)
Ig strand C 284..288 CDD:409353 1/3 (33%)
Ig strand E 308..311 CDD:409353 0/2 (0%)
Ig strand F 321..326 CDD:409353 2/4 (50%)
Ig strand G 334..337 CDD:409353 1/2 (50%)
Ig 346..437 CDD:472250 25/90 (28%)
Ig strand B 362..366 CDD:409353 0/3 (0%)
Ig strand C 376..380 CDD:409353 1/3 (33%)
Ig strand E 402..406 CDD:409353 2/3 (67%)
Ig strand F 416..421 CDD:409353 2/4 (50%)
Ig strand G 430..433 CDD:409353 1/2 (50%)
Ig <459..530 CDD:472250 2/70 (3%)
Ig strand B 459..462 CDD:409353 0/2 (0%)
Ig strand C 471..476 CDD:409353 0/4 (0%)
Ig strand E 496..500 CDD:409353 0/3 (0%)
Ig strand F 510..515 CDD:409353 0/4 (0%)
Ig strand G 523..526 CDD:409353 0/2 (0%)
Ig_3 535..615 CDD:464046 21/80 (26%)
FN3 633..725 CDD:238020 22/108 (20%)
FN3 786..874 CDD:238020 22/95 (23%)
robo4XP_689255.3 IgC_1_Robo 71..169 CDD:409490 31/102 (30%)
Ig strand A 71..75 CDD:409490 2/3 (67%)
Ig strand A' 78..83 CDD:409490 1/5 (20%)
Ig strand B 87..95 CDD:409490 2/7 (29%)
Ig strand C 101..106 CDD:409490 2/4 (50%)
Ig strand C' 109..111 CDD:409490 0/1 (0%)
Ig strand D 122..125 CDD:409490 2/4 (50%)
Ig strand E 128..134 CDD:409490 1/5 (20%)
Ig strand F 146..154 CDD:409490 4/9 (44%)
Ig strand G 157..169 CDD:409490 3/11 (27%)
IgI_2_Robo 176..261 CDD:409389 25/88 (28%)
Ig strand A 176..179 CDD:409389 1/2 (50%)
Ig strand A' 181..185 CDD:409389 0/3 (0%)
Ig strand B 189..196 CDD:409389 1/6 (17%)
Ig strand C 204..209 CDD:409389 2/4 (50%)
Ig strand C' 211..214 CDD:409389 1/2 (50%)
Ig strand D 220..224 CDD:409389 1/3 (33%)
Ig strand E 226..232 CDD:409389 4/5 (80%)
Ig strand F 239..247 CDD:409389 3/7 (43%)
Ig strand G 250..261 CDD:409389 4/10 (40%)
Ig 268..350 CDD:472250 27/96 (28%)
Ig strand B 282..286 CDD:409353 0/3 (0%)
Ig strand C 295..299 CDD:409353 1/3 (33%)
Ig strand E 316..320 CDD:409353 0/3 (0%)
Ig strand F 330..335 CDD:409353 2/4 (50%)
Ig strand G 343..346 CDD:409353 1/2 (50%)
FN3 373..448 CDD:214495 19/75 (25%)
FN3 472..560 CDD:238020 27/146 (18%)

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