DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and igsf9b

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	XP_686205.6	Gene:	igsf9b / 553348	ZFINID:	ZDB-GENE-060810-28	Length:	2021	Species:	Danio rerio

Alignment Length:	1461	Identity:	375/1461 - (25%)
Similarity:	602/1461 - (41%)	Gaps:	348/1461 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 PNDHPVPYVLQWDKKVSETGSDLPIYIWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRE 219
            ||..|: :|::|.:    .|.::||.|.:.||...:...|||||| :|:     .|||.:..:..
Zfish    54 PNLFPL-HVVEWVR----LGYNVPILIKFGSYTPRVHPNYKGRVS-LSR-----GASLMVEKLTL 107

  Fly   220 SDQGWYECKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTPE 284
            .|:||:||:::.|:|...:.:||||..|.:.|||.|..||...:.|.||:|:.|:|.|.|.|.|.
Zfish   108 EDEGWFECRILLLDRTSDEFQNGTWNFLSITAPPVFIKTPPPFLEVLLGESLTLHCDAHGNPKPT 172

  Fly   285 ILWYKDANPVDPSPTVGIFNDGTELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMV 349
            |:|.|..:..:....:.:.|:  .|.:|.:..|..|.|.|...|.||.::|:.::.:.|..:|::
Zfish   173 IIWRKYLSAAEKQEEIQVLNE--TLSLSKVTRETAGIYKCHVSNSEGNLTHSTQLQVKGPPIIII 235

  Fly   350 PPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIINPIKPDDS 414
            .|.:.|....:..:..|:|:|.|.|:|..|:::|..|..:..|::||.|..||:|:|:.:.||||
Zfish   236 APEDTTMNMSQDAVLQCQAEAYPSNLTYEWWKQGQNVYHIEILKSRVKILVDGTLLISALIPDDS 300

  Fly   415 GQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTKDK 479
            |.|.|..|||:..|.:|||||:|::||:|...|...|||..:.|.:.|.:::.|.:.||.||||.
Zfish   301 GNYTCRPTNGLMTPPAASAYLTVKHPARVVRMPRETYLPMGMGGKIPCPVQAEPPMLYVNWTKDG 365

  Fly   480 RLLEPYQMKDIVVMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEPET 544
            ..|...|....:|.:.||:..|..|::..|.|.||.||:.||.|.|....|:::.||:|.|.|..
Zfish   366 ASLNLEQYPGWMVNSEGSVFITAANDDAVGMYTCTAYNSYGTMGQSEPTKVILKDPPSFRVSPRA 430

  Fly   545 LYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRIKI-SGGNITIENLRREDFGY 608
            .|.::||..:.:.|   :::|...|.|.|.:     :..:.|:...: |.|::.:..|.::..|.
Zfish   431 EYLQEVGRDLVIPC---QSQGDPSPNITWIK-----VGPAPRSPFTVLSNGSLFLRPLSKDHQGT 487

  Fly   609 YQCVVSNEVATLMAVTQLVIEGTQPHAPYNITGKATESSITLQWLPGYSGGSEYKQDYTIWFREA 673
            ::|:.||.|||:...|.:::.||.|||..:::.........:.|..|:.||  |.|.:|:|.:..
Zfish   488 WECLASNRVATVSVATTILVLGTSPHAVTSVSVDPGIGQANVSWEAGFDGG--YTQRFTVWVKPT 550

  Fly   674 --GVNDWQTISVTPSGSTQVTINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAAPRNV 736
              |.::|.:|.| |:..|.:.:..|...|:|:|.|:.:|.||.|..|:::|::||     ||
Zfish   551 VRGKHEWASIPV-PTSKTSLLVTSLQPATSYQFSVLAQNKLGSGPFSEIVTIKTL-----AP--- 606

  Fly   737 KAATQPPDSFFQLMPDEADLLAYFDIYFHTDSRGTLVYSPPKLRVKGPKPGPPRNVSVTEVSNGF 801
                 |.:|     |.....:|              |.|||.|            :|....|.|.
Zfish   607 -----PTES-----PTVLTTMA--------------VLSPPTL------------LSANRTSLGV 635

  Fly   802 LITWQSPLERAHIVKFYTIKYRTDAQWKTLNRGQIRPEETQYLVKNLVGGRTYYFRVLANSEKSY 866
            |:.|..|||.: :..|.....|...:|.|::| :|....|:.:|:.||....|..|:|:..:|..
Zfish   636 LLQWVPPLEES-LTSFALQAKRGKGEWVTIDR-EIAVNMTELIVQGLVKDSKYELRLLSCQDKLV 698

  Fly   867 E-SSDEVKFPVPARVKHKA-----------ITAGVVGGILFFIVAIILSVCAVKICNKRKRRKQE 919
            . .||.|.........:.|           :.|||:||:.|..||||||:....:.|.::|::::
Zfish   699 SVPSDSVLISTEGMEMYPAAPSLLAFVPEPLLAGVIGGVCFLFVAIILSLVTACVMNSKRRQRRQ 763

  Fly   920 KEFNMVACRITDARNIAAN----------------------NHHLHNRSTGSISSGQVPLKKY-- 960
            |:.:.:......:....||                      |....:||..| |..:....:|
Zfish   764 KKRDDIPSAFQKSSAPQANSPSDSPDSLLKLKLCPPLNFFPNSSSSDRSDRS-SFDKASRSEYQD 827

  Fly   961 -KQTRISSLTAILIAILHWIWPPDRCTNCHSIYSSPNLEDGDEDDGGGGRRRSVSRIQRSLDGRF 1024
             |:..:||.:           ||...|...|.:.           |......::..|.||.||||
Zfish   828 QKKQLLSSSS-----------PPPHYTQFESHFG-----------GTPSPTPAIESISRSPDGRF 870

  Fly  1025 VL--DVEGVSKLGYSQQTLESGNVDVVDGGLFERRNSNVSQKSSSDDGGFLSRRNFITARASWRR 1087
            ::  |:|...|      .|:..         |.:..|..|.:.|| :|.|.......:||:.
Zfish   871 IIQPDLENFKK------NLKKE---------FPQSPSRGSGRGSS-NGSFKESNQSNSARSE--- 916

  Fly  1088 PLVASSSQLSLQSAADSARGFLQGLLKIGAKQSAVPPNSQSYFDEAVSGARYQNVLRPYTSSNNL 1152
                :::|..:.||           |.:.......||:|
Zfish   917 ----TNAQTEMPSA-----------LTVDHPHLERPPHS-------------------------- 940

  Fly  1153 YGNADRSRPLHINTISGSLSQQQQLYTPSRISRIFSSSPQQLQPHHQQLLLSSGGSGAYPTHFSD 1217
                    |..:..::.:.|:....|:..                      ..|||.|    ..:
Zfish   941 --------PGRVRAMARNFSRHGCFYSDD----------------------EHGGSEA----LLE 971

  Fly  1218 LSTVYPPNSAERSSHNLSSRYR--YYSQEL-PSLRTIQEETRRQQQQKQHPLEDHFVPL----QL 1275
            .::.|...|.:::|.:| .:||  .:.:|: |||      |||.:::.:...:.|:.|:    ||
Zfish   972 RASFYSDCSEKKASDSL-KKYRGAIHREEIFPSL------TRRTRERDRMLQQAHYQPINGDSQL 1029

  Fly  1276 PSPPSWRSYYQSQ------------ASYRPRTRWYPRHHSRLFSNRQQQHE-------MLSPL-- 1319
            ..|.:..:....:            |..|.:......|::.  |.|.|.||       ..|||
Zfish  1030 TEPSTMITQLDGERERDNLSKCLKLAKEREQMEKELEHYTA--SRRVQAHEREQRRAKSASPLRK 1092

  Fly  1320 ------------PQLNLNLRNSMNPGGLEASPESRSSSSGFGSKNTSN----HPGSTS---EWRL 1365
                        || ::.||....|..|............||  |||:    ||.|:|   :|.:
Zfish  1093 WTGVESQDPIWKPQ-DIQLRQKSRPSSLAQHVSDNRRGCYFG--NTSSPMERHPSSSSSYIQWDI 1154

  Fly  1366 LPPYRAPPSPPKHSGYFGGQQAQGQTPHGSYSYPRATTPPYTMAHWLEMISRLNAATDSNLPKAP 1430
            .|........|..|      .::|.|||..|                           .|:.:..
Zfish  1155 SPVTSPTSLVPVQS------LSEGNTPHSLY---------------------------PNMRQQA 1186

  Fly  1431 CPVDVGSVDGHYEFDPATPTPSASSMLREDLNLHIDTHPYHHHTLGPLSGSLLHSHAPYGGGARK 1495
            .|...||........|||...|.|.     ...|.::.|         |.|.||     |..||.
Zfish  1187 IPNVEGSSATGISHSPATQYTSLSI-----FTPHRESSP---------SRSSLH-----GAQARY 1232

  Fly  1496 QRS-LPAHLPRYDNVEVRLQAMREEFYAYRK 1525
            ..| |...||....||       |.:.|.||
Zfish  1233 SESQLEEELPNRTLVE-------ESWLAERK 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	33/94 (35%)
		IG_like	137..229	CDD:214653	26/73 (36%)
		I-set	253..341	CDD:254352	28/87 (32%)
		IGc2	268..331	CDD:197706	19/62 (31%)
		I-set	346..437	CDD:254352	36/90 (40%)
		Ig	349..437	CDD:299845	35/87 (40%)
		Ig	459..530	CDD:299845	25/70 (36%)
		IG_like	549..628	CDD:214653	19/79 (24%)
		IGc2	551..617	CDD:197706	14/66 (21%)
		FN3	633..725	CDD:238020	28/93 (30%)
		FN3	786..874	CDD:238020	25/88 (28%)
igsf9b	XP_686205.6	Ig	27..132	CDD:299845	30/88 (34%)
		IG_like	148..227	CDD:214653	24/80 (30%)
		IGc2	156..217	CDD:197706	19/62 (31%)
		Ig	237..323	CDD:299845	35/85 (41%)
		IG_like	237..323	CDD:214653	35/85 (41%)
		Ig	345..411	CDD:143165	24/65 (37%)
		IG_like	435..507	CDD:214653	19/79 (24%)
		IGc2	437..496	CDD:197706	14/66 (21%)
		FN3	512..603	CDD:238020	28/93 (30%)
		FN3	621..709	CDD:238020	29/101 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I8696
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D151368at33208
OrthoFinder	1	1.000	-	-		FOG0002337
OrthoInspector	1	1.000	-	-		otm24272
orthoMCL	1	0.900	-	-		OOG6_104975
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1123
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820